Results 101 to 110 of about 10,115,388 (315)

Between Realism and Non-Cognitivism in Ethics, A Three-Fold-Model. A Three-Fold-Model [PDF]

open access: yes, 2011
The aim of the paper is to propose an alternative model to realist and non-cognitive explanations of the rule-guided use of thick ethical concepts and to examine the implications that may be drawn from this and similar cases for our general understanding of rule-following and the relation between criteria of ap- plication, truth and correctness.
openaire   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Folding and fibril formation of prions [PDF]

open access: yes
Prions diseases are a group of fatal neurodegenerative disorders called the transmissible spongiform encephalopathies (TSEs), which include bovine spongiform encephalopathy in cattle, scrapie in sheep and Creutzfeldt-Jakob disease (CJD) in humans ...
Gierusz, Leszek A.
core  

Folding Transformation Rules for Constraint Logic Programs [PDF]

open access: yes, 2008
We consider the folding transformation rule for constraint logic programs. We propose an algorithm for applying the folding rule in the case where the constraints are linear equations and inequations over the rational or the real numbers. Basically, our
Senni, Valerio   +2 more
core  

Simplified models for protein cotranslational folding [PDF]

open access: yes, 2022
openLe proteine globulari ripiegano in una struttura tridimensionale nativa, biologicamente attiva, univocamente determinata dalla sequenza di aminoacidi.
FELTRIN, ANTONIO
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Minimal Retraction of Space-time and Their Foldings [PDF]

open access: yes, 2009
The folding of a manifold was, firstly introduced by Robertson in [1977] . Since then many authers have studied the folding of manifolds s. The deformation retracts of the manifolds defined and discussed.
El-Ahmady, A. E., Rafat, H.
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

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