Results 81 to 90 of about 222,091 (247)

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Finite element analysis of the folding process of creased white-coated paperboard using a combined fluffing resistance and shear yield glue model

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2018
This study aims to develop a numerical simulation model of the folding process of a creased paperboard and to reveal the deformation characteristics of the creased paperboard.
Weerayut JINA, Shigeru NAGASAWA
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Calculation of the Hinge Moments of a Folding Wing Aircraft during the Flight-Folding Process

International Journal of Aerospace Engineering, 2019
A folding wing morphing aircraft should complete the folding and unfolding process of its wings while in flight. Calculating the hinge moments during the morphing process is a critical aspect of a folding wing design.
Hao Xu, Jinglong Han, Haiwei Yun, Xiaomao Chen   +3 more
doaj   +1 more source

How the cortex gets its folds: an inside-out, connectivity-driven model for the scaling of mammalian cortical folding

Frontiers in Neuroanatomy, 2012
Larger mammalian cerebral cortices tend to have increasingly folded surfaces, often considered to result from the lateral expansion of the grey matter (GM), which, in a volume constrained by the cranium, causes mechanical compression that is relieved by ...
Bruno eMota, Bruno eMota, Suzana eHerculano-Houzel, Suzana eHerculano-Houzel   +3 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

AlphaFold distillation for inverse protein design

Scientific Reports
Inverse protein folding, the process of designing sequences that fold into a specific 3D structure, is crucial in bio-engineering and drug discovery. Traditional methods rely on experimentally resolved structures, but these cover only a small fraction of
Igor Melnyk, Aurélie Lozano, Payel Das, Vijil Chenthamarakshan   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Mechanism of DNA origami folding elucidated by mesoscopic simulations

Nature Communications
Many experimental and computational efforts have sought to understand DNA origami folding, but the time and length scales of this process pose significant challenges.
Marcello DeLuca, Daniel Duke, Tao Ye, Michael Poirier, Yonggang Ke, Carlos Castro, Gaurav Arya   +6 more
doaj   +1 more source