Results 121 to 130 of about 220,518 (289)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Calculation of the Hinge Moments of a Folding Wing Aircraft during the Flight-Folding Process

International Journal of Aerospace Engineering, 2019
A folding wing morphing aircraft should complete the folding and unfolding process of its wings while in flight. Calculating the hinge moments during the morphing process is a critical aspect of a folding wing design.
Hao Xu, Jinglong Han, Haiwei Yun, Xiaomao Chen   +3 more
doaj   +1 more source

Probing the isoscalar excitations of 12C with inelastic alpha scattering

, 2008
The robust (spin and isospin zero) $\alpha$-particle remains one of the best projectiles to probe the nuclear isoscalar excitations. In the present work, a microscopic folding model analysis of the \ac inelastic scattering to the 2$^+$ (4.44 MeV), 0$^+$ (
DAO T. KHOA, Satchler G. R.
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Predicting protein folding pathways at the mesoscopic level based on native interactions between secondary structure elements

BMC Bioinformatics, 2008
Background Since experimental determination of protein folding pathways remains difficult, computational techniques are often used to simulate protein folding.
Sze Sing-Hoi, Yang Qingwu
doaj   +1 more source

Determination of Li-6 -- He-4 interaction from multi-energy scattering data

, 1998
We present the first successful potential model description of Li-6 -- He-4 scattering. The differential cross-sections for three energies and the vector analyzing powers for two energies were fitted by a single potential with energy dependent imaginary ...
Bingham, Cooper, Cooper, Cooper, Cooper, Cooper, Cooper, Cooper, George, Green, Ioannides, Kamal, Kukulin, Kukulin, Kukulin, Kukulin, Mackintosh, Mackintosh, Mackintosh, Mackintosh, Mackintosh, R.S. Mackintosh, Rusek, S.G. Cooper, Satchler, Suelze, V.I. Kukulin   +26 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

The continuum discretized coupled-channels method and its applications

, 2012
This is a review on recent developments of the continuum discretized coupled-channels method (CDCC) and its applications to nuclear physics, cosmology and astrophysics, and nuclear engineering.
Matsumoto, Takuma, Minomo, Kosho, Ogata, Kazuyuki, Yahiro, Masanobu   +3 more
core   +1 more source

Improved design of stable and fast-folding model proteins

Folding and Design, 1996
A number of approaches to design stable and fast-folding sequences for model polypeptide chains have been based on the premise that optimization of the relative energy of the native conformation (or Z-score) is sufficient to yield stable and fast-folding sequences. Although this approach has been successful, for longer chains it often yielded sequences
Abkevich, Victor I, Gutin, Alexander M, Shakhnovich, Eugene I   +2 more
openaire   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source