Results 131 to 140 of about 220,518 (289)
AlphaFold distillation for inverse protein design
Scientific ReportsInverse protein folding, the process of designing sequences that fold into a specific 3D structure, is crucial in bio-engineering and drug discovery. Traditional methods rely on experimentally resolved structures, but these cover only a small fraction of
Igor Melnyk +3 more
doaj +1 more source
, 2005 The RPA long range correlations are known to play a significant role in understanding the depletion of single particle-hole states observed in (e, e') and (e, e'p) measurements.
C. Mahaux +14 more
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Synthetic, Multi-Layer, Self-Oscillating Vocal Fold Model Fabrication
Journal of Visualized Experiments, 2011 Sound for the human voice is produced via flow-induced vocal fold vibration. The vocal folds consist of several layers of tissue, each with differing material properties. Normal voice production relies on healthy tissue and vocal folds, and occurs as a result of complex coupling between aerodynamic, structural dynamic, and acoustic physical phenomena ...
Preston R, Murray, Scott L, Thomson
openaire +3 more sources
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Mechanism of DNA origami folding elucidated by mesoscopic simulations
Nature CommunicationsMany experimental and computational efforts have sought to understand DNA origami folding, but the time and length scales of this process pose significant challenges.
Marcello DeLuca +6 more
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, 2004 The possibility of deriving the contact potentials between amino acids from their frequencies of occurence in proteins is discussed in evolutionary terms.
Abkkevich V I +20 more
core +1 more source
Between Realism and Non-Cognitivism in Ethics, A Three-Fold-Model. A Three-Fold-Model [PDF]
, 2011 The aim of the paper is to propose an alternative model to realist and non-cognitive explanations of the rule-guided use of thick ethical concepts and to examine the implications that may be drawn from this and similar cases for our general understanding of rule-following and the relation between criteria of ap- plication, truth and correctness.
openaire
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Jixie chuandong, 2009 The special high-speed wind tunnel test model is a difficult problem in the aviation field. Aiming at the movement performance index of one morphing aircraft for high-speed wind tunnel,the controllable-folding morphing test model is designed.
李强, 李周复, 刘铁中
doaj