Results 81 to 90 of about 217,044 (288)

Tissue-scale in vitro epithelial wrinkling and wrinkle-to-fold transition

Nature Communications
Although epithelial folding is commonly studied using in vivo animal models, such models exhibit critical limitations in terms of real-time observation and independent control of experimental parameters.
Jaeseung Youn, Dohui Kim, Hyunsu Kwak, Anna Lee, Dong Sung Kim   +4 more
doaj   +1 more source

Deep clustering of protein folding simulations

BMC Bioinformatics, 2018
Background We examine the problem of clustering biomolecular simulations using deep learning techniques. Since biomolecular simulation datasets are inherently high dimensional, it is often necessary to build low dimensional representations that can be ...
Debsindhu Bhowmik, Shang Gao, Michael T. Young, Arvind Ramanathan   +3 more
doaj   +1 more source

Deriving amino acid contact potentials from their frequencies of occurence in proteins: a lattice model study

, 2004
The possibility of deriving the contact potentials between amino acids from their frequencies of occurence in proteins is discussed in evolutionary terms.
Abkkevich V I, Anfinsen C B, Betancourt M R, Bryngelson J D, Creighton T E, D Provasi, Derrida B, Finkelstein A V, G Tiana, Godzik A, Greiner W, Kolinski A, Li H, M Colombo, Miyazawa S, R A Broglia, Rost B, Shakhnovich E I, Shimada J, Sippl M J, Zhang L   +20 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Magnetic tweezers to capture the fast-folding λ6-85 in slow motion

Communications Physics
Force spectroscopy gives access to the underlying free energy landscape of protein folding. Proteins exhibit folding rates between microseconds and hours.
César Augusto Quintana-Cataño, Ann Mukhortava, Mordjane A. Boukhet, Andreas Hartmann, Karl-Ludwig Schumann, Michael Schlierf   +5 more
doaj   +1 more source

Microscopic optical potentials for $^4$He scattering

, 2014
We present a reliable double-folding (DF) model for $^{4}$He-nucleus scattering, using the Melbourne $g$-matrix nucleon-nucleon interaction that explains nucleon-nucleus scattering with no adjustable parameter. In the DF model, only the target density is
Egashira, Kei, Matsumoto, Takuma, Minomo, Kosho, Toyokawa, Masakazu, Yahiro, Masanobu   +4 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Flutter Characteristics of a Modified Z-Shaped Folding Wing Using a New Non-Intrusive Model

Aerospace
Unmanned aerial vehicles (UAVs) with folding wings can serve in multiple mission profiles, usually accompanied by sudden changes in flight speed. These bring great challenges to the aeroelastic design of UAVs, especially in the calculation of flutter ...
Wuchao Qi, Shimiao Wu, Sumei Tian
doaj   +1 more source

The dominant folding route minimizes backbone distortion in SH3.

PLoS Computational Biology, 2012
Energetic frustration in protein folding is minimized by evolution to create a smooth and robust energy landscape. As a result the geometry of the native structure provides key constraints that shape protein folding mechanisms.
Heiko Lammert, Jeffrey K Noel, José N Onuchic   +2 more
doaj   +1 more source

A complex adaptive systems approach to the kinetic folding of RNA

, 2005
The kinetic folding of RNA sequences into secondary structures is modeled as a complex adaptive system, the components of which are possible RNA structural rearrangements (SRs) and their associated bases and base pairs. RNA bases and base pairs engage in
Abrahams, Baker, Cannone, Fisher, Flamm, Fontana, Freier, Gratias, Gultyaev, Hadany, Higgs, Hofacker, Isambert, Kauffman, Kauffman, Kawasaki, Lee, Levin, Mathews, Mathews, McCarthy, Metropolis, Mironov, Mochizuki, Morgan, Nagel, Ndifon, Poerschke, Poerschke, Schuster, Schuster, Schuster, Skellett, Tang, Vitreschack, Wilfred Ndifon, Woese, Wolfinger, Xayaphoummine, Yang, Zamora, Zhang   +41 more
core   +3 more sources