Results 91 to 100 of about 15,380 (223)

Targeting Glycolysis with Epigallocatechin-3-Gallate Enhances the Efficacy of Chemotherapeutics in Pancreatic Cancer Cells and Xenografts. [PDF]

, 2019
Pancreatic cancer is a complex disease, in need of new therapeutic approaches. In this study, we explored the effect and mechanism of action of epigallocatechin-3-gallate (EGCG), a major polyphenol in green tea, alone and in combination with current ...
Hackman, Robert M, Mackenzie, Gerardo G, Wang, Yuefei, Wei, Ran   +3 more
core   +1 more source

Pancreatic Cancer—Advances in the Last 50 Years

World Journal of Surgery, EarlyView.
S. George Barreto, Anirban Maitra, Eileen M. O'Reilly, Dushyant Sahani, Richard Zheng, Charles J. Yeo   +5 more
wiley   +1 more source

Cancer‐Associated Fibroblasts Functions as Multifunctional Architects of the Tumor Stroma and Represent Emerging Therapeutic Vulnerabilities

Advanced Science, Volume 13, Issue 24, 27 April 2026.
ABSTRACT Cancer‐associated fibroblasts (CAFs) are the predominant stromal components within the tumor microenvironment (TME), playing multifaceted roles in cancer progression through dynamic interactions with neoplastic and immune cells. Emerging evidence has revealed remarkable heterogeneity and plasticity of CAFs, which originate from diverse ...
Rujiao Liu, Lili Su, Shuiping Gao, Wenting Liu, Hongxia Wang   +4 more
wiley   +1 more source

A liquid biomarker signature of inflammatory proteins accurately predicts early pancreatic cancer progression during FOLFIRINOX chemotherapy

Neoplasia: An International Journal for Oncology Research
Background: Pancreatic ductal adenocarcinoma (PDAC) is often treated with FOLFIRINOX, a chemotherapy associated with high toxicity rates and variable efficacy.
Casper W.F. van Eijck, Sergio Sabroso-Lasa, Gaby J. Strijk, Dana A.M. Mustafa, Amine Fellah, Bas Groot Koerkamp, Núria Malats, Casper H.J. van Eijck   +7 more
doaj   +1 more source

Efficacy and feasibility of stereotactic radiotherapy after folfirinox in patients with locally advanced pancreatic cancer (LAPC-1 trial)

EClinicalMedicine, 2019
Background: We conducted a multicentre phase II trial to investigate feasibility and antitumor activity of sequential FOLFIRINOX and Stereotactic Body Radiotherapy (SBRT) in patients with locally advanced pancreatic cancer (LAPC), (LAPC-1 trial). Methods:
Mustafa Suker, Joost J. Nuyttens, Ferry A.L.M. Eskens, Brigitte C.M. Haberkorn, Peter-Paul L.O. Coene, Erwin van der Harst, Bert A. Bonsing, Alexander L. Vahrmeijer, J.Sven D. Mieog, Rutger Jan Swijnenburg, Daphne Roos, B.Groot. Koerkamp, Casper H.J. van Eijck   +12 more
doaj   +1 more source

Reduced FBXW7 expression in pancreatic cancer correlates with poor prognosis, and chemotherapeutic resistance via accumulation of MCL1 [PDF]

, 2018
学位記番号 ...
Ishii, Norihiro, イシイ, ノリヒロ, 石井, 範洋   +2 more
core  

Emerging concepts in pancreatic cancer medicine: targeting the tumor stroma [PDF]

, 2013
Pancreatic ductal adenocarcinoma is a stroma-rich and highly challenging cancer to treat. Over recent years, it has become increasingly evident that the complex network of soluble cytokines, growth factors, proteases, and components of the extracellular ...
Gress, T. M., Krug, S., Michl, P., Neesse, A., Tuveson, D. A.   +4 more
core   +1 more source

Effect of First‐Line Chemotherapy Alone Versus First‐Line Chemotherapy Plus Radiotherapy on Survival in Patients With Locally Advanced Pancreatic Cancer in the IMRT Era: A Retrospective Cohort Study

Cancer Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background The role of intensity‐modulated radiotherapy (IMRT) and novel combination chemotherapy regimens in locally advanced pancreatic cancer (LAPC) remains unclear. In this study, we focused on comparing survival between first‐line chemotherapy alone and first‐line chemotherapy plus IMRT in patients with LAPC.
Zihao Liu, Yaru Tian, Ji Ma, Dong‐Fang Meng   +3 more
wiley   +1 more source

Mesenteric-Portal Vein Resection during Pancreatectomy for Pancreatic Cancer [PDF]

, 2015
The aim of the present study was to determine the outcome of patients undergoing pancreatic resection with (VR+) or without (VR 12) mesenteric-portal vein resection for pancreatic carcinoma.
Beltrame, Valentina, Gruppo, Mario, Merigliano, Stefano, Pastorelli, Davide, Pedrazzoli, Sergio, Sperti, Cosimo   +5 more
core   +4 more sources

Endoscopic Ultrasound‐Guided Bile Duct Drainage Enhances Oncological Systemic Therapy Initiation and Capability in Patients With Non‐Resectable Malignant Distal Bile Duct Obstructions Compared to Percutaneous Transhepatic Biliary Drainage

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Introduction Endoscopic retrograde cholangiopancreaticography (ERCP) is the gold standard for bile duct drainage in non‐resectable malignant distal bile duct obstruction with jaundice in pancreaticobiliary and duodenal neoplasia. Failed ERCP is either followed by endoscopic ultrasound‐guided biliary drainage (EUS‐BD) or percutaneous ...
Thomas Roland Heiduk, Andre Sasse, Volker Ellenrieder, Lukas Hiebel, Richard Friedemann Knoop, Golo Petzold, Ahmad Amanzada   +6 more
wiley   +1 more source