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Purification of Folic Acid

Science, 1959
Various purification procedures for folic acid were investigated. The criteria of purity were a negative Bratton-Marshall test and the absence of fluorescent spots on paper chromatograms. Since no method provided a pure product, a procedure consisting of cellulose column chromatography followed by filtration through charcoal was developed.
W, SAKAMI, R, KNOWLES
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Folic acid and psychopathology

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1989
1. The incidence of folic acid deficiency is high in patients with various psychiatric disorders including depression, dementia and schizophrenia. 2. In epileptics on anticonvulsants, folate deficiency often occurs because anticonvulsants inhibit folate absorption. In these patients folate deficiency is often associated with psychiatric symptoms. 3. In
S N, Young, A M, Ghadirian
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A 2019 global update on folic acid‐preventable spina bifida and anencephaly

Birth Defects Research, 2020
Mandatory folic acid fortification of staples is a proven intervention to prevent spina bifida and anencephaly, two life‐threatening and disabling neural tube defects.
V. Kancherla   +3 more
semanticscholar   +1 more source

Epilepsy and Folic Acid

Psychiatry and Clinical Neurosciences, 1977
SUMMARYWith 15 cases of epilepsy as the subject, studies were made of the therapeutic effects of folic acid on psychiatric symptoms and clinical seizures. Folic acid proved effective for a part of chronic and prolonged psychiatric symptoms shown by epileptic patients and brought on slight improvement in hyperexcitability, aggressiveness, bad humor and ...
S, Ueda   +3 more
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3D reduced graphene oxide/FeNi3-ionic liquid nanocomposite modified sensor; an electrical synergic effect for development of tert-butylhydroquinone and folic acid sensor

Composites Part B: Engineering, 2019
This paper reports an electroanalytical sensor developed based on reduced graphene oxide/FeNi3 (FeNi3/rGO)-ionic liquid (n-hexyl-3-methylimidazolium hexafluoro phosphate (HMPF6) carbon paste electrode (CPE) for determining the antioxidant additive ...
Fahimeh Tahernejad-Javazmi   +2 more
semanticscholar   +1 more source

Folic Acid and the Pill

Scandinavian Journal of Haematology, 1972
Three cases of folic acid deficient megaloblastic anaemia are described in which a combined oral contraceptive has been aetiologically implicated. The first patient proved to have coeliac disease precipitated clinically by administration of the oral contraceptive. Case 2 had a long standing marginally folate deficient diet and became anaemic only after
J K, Wood, A H, Goldstone, N C, Allan
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Folic acid functionalized nanoparticles as pharmaceutical carriers in drug delivery systems

Drug development research (Print), 2019
Conventional chemotherapeutic approaches in cancer therapy such as surgery, chemotherapy, and radiotherapy have several disadvantages due to their nontargeted distributions in the whole body.
Asghar Narmani   +7 more
semanticscholar   +1 more source

Effects Of Folic Acid And Vitamin B 12 , Alone and in Combination on Cognitive Function and inflammatory Factors in the Elderly with Mild Cognitive Impairment: A Single-Blind Experimental Design.

Current Alzheimer Research, 2019
BACKGROUND Folate and vitamin B 12  are well acknowledged as essential nutrients that play key roles in the normal functions of brain. Inflammatory processes play at least some role in the pathology of AD.
F. Ma   +8 more
semanticscholar   +1 more source

Encapsulation of folic acid in copper-alginate hydrogels and it's slow in vitro release in physiological pH condition.

Food Research International, 2019
Folic acid (FA) is an essential micronutrient but its delivery and bioavailability is a problem due to its inherent instability at various conditions. A robust protective encapsulation system for folic acid is highly desirable.
D. Camacho   +4 more
semanticscholar   +1 more source

Photogenotoxicity of folic acid

Free Radical Biology and Medicine, 2013
Folic acid (FA), also named vitamin B9, is an essential cofactor for the synthesis of DNA bases and other biomolecules after bioactivation by dihydrofolate reductase (DHFR). FA is photoreactive and has been shown to generate DNA modifications when irradiated with UVA (360 nm) in the presence of DNA under cell-free conditions.
Kathrin, Butzbach, Bernd, Epe
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