Intracellular Follicle-Stimulating Hormone Receptor Trafficking and Signaling [PDF]
Frontiers in Endocrinology, 2018 Models of G protein-coupled receptor (GPCR) signaling have dramatically altered over the past two decades. Indeed, GPCRs such as the follicle-stimulating hormone receptor (FSHR) have contributed to these new emerging models.
Niamh Sayers, Aylin C. Hanyaloglu
doaj +9 more sources
Structure-Function Relationships of the Follicle-Stimulating Hormone Receptor [PDF]
Frontiers in Endocrinology, 2018 The follicle-stimulating hormone receptor (FSHR) plays a crucial role in reproduction. This structurally complex receptor is a member of the G-protein coupled receptor (GPCR) superfamily of membrane receptors.
Alfredo Ulloa-Aguirre +4 more
doaj +6 more sources
Small Molecule Follicle-Stimulating Hormone Receptor Agonists and Antagonists [PDF]
Frontiers in Endocrinology, 2019 The follicle-stimulating hormone receptor (FSHR) has been targeted therapeutically for decades, due to its pivotal role in reproduction. To date, only purified and recombinant/biosimilar FSH have been used to target FSHR in assisted reproduction, with ...
Ross C. Anderson +3 more
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Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor [PDF]
Nature Communications, 2023 Follicle stimulating hormone (FSH) is a glycoprotein hormone the functions of which are mediated by a G protein-coupled receptor, FSHR. Here, Duan et al.
Jia Duan +14 more
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Profile of follicle-stimulating hormone and polymorphism of follicle-stimulating hormone receptor in Madrasin cattle with ovarian hypofunction [PDF]
Veterinary World, 2020 Background and Aim: The follicle-stimulating hormone (FSH) gene is an essential regulator of fertility in livestock. This study aims to provide information on the genetic makeup of Madrasin cattle experiencing hypofunction by the FSH profile and FSH ...
Budi Utomo +2 more
doaj +5 more sources
Membrane Estrogen Receptor (GPER) and Follicle-Stimulating Hormone Receptor (FSHR) Heteromeric Complexes Promote Human Ovarian Follicle Survival [PDF]
iScience, 2020 Summary: Classically, follicle-stimulating hormone receptor (FSHR)-driven cAMP-mediated signaling boosts human ovarian follicle growth and oocyte maturation.
Livio Casarini +25 more
doaj +3 more sources
Follicle Stimulating Hormone Receptor (FSHR) Polymorphisms and Polycystic Ovary Syndrome (PCOS) [PDF]
Frontiers in Endocrinology, 2019 Polycystic ovary syndrome (PCOS) is the commonest endocrine abnormality in women of reproductive age typically presenting with chronic oligo- or anovulation, clinical, or biochemical hyperandrogenism and polycystic ovarian morphology (PCOM).
Joop S. E. Laven
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Autoimmunity to the Follicle-Stimulating Hormone Receptor (FSHR) and Luteinizing Hormone Receptor (LHR) in Polycystic Ovarian Syndrome. [PDF]
Int J Mol Sci, 2021 Hyperandrogenemia and ovulatory dysfunction are hallmarks of polycystic ovary syndrome (PCOS), pointing to a deranged hypothalamus-pituitary-ovarian (HPO) axis.
Schniewind HA +6 more
europepmc +2 more sources
Discovery and Preclinical Development of Orally Active Small Molecules that Exhibit Highly Selective Follicle Stimulating Hormone Receptor Agonism [PDF]
Frontiers in Pharmacology, 2021 An orally active follicle stimulating hormone receptor allosteric agonist would provide a preferred treatment for over 16 million infertile women of reproductive age in low complexity methods (ovulation induction-intrauterine insemination) or in high ...
Selva Nataraja +4 more
doaj +2 more sources
Endocrine Disruption of the Follicle-Stimulating Hormone Receptor Signaling During the Human Antral Follicle Growth [PDF]
Frontiers in Endocrinology, 2021 An increasing number of pollutants with endocrine disrupting potential are accumulating in the environment, increasing the exposure risk for humans.
Neena Roy +13 more
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