Intracellular Follicle-Stimulating Hormone Receptor Trafficking and Signaling [PDF]
Frontiers in Endocrinology, 2018 Models of G protein-coupled receptor (GPCR) signaling have dramatically altered over the past two decades. Indeed, GPCRs such as the follicle-stimulating hormone receptor (FSHR) have contributed to these new emerging models.
Niamh Sayers, Aylin C. Hanyaloglu
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Profile of follicle-stimulating hormone and polymorphism of follicle-stimulating hormone receptor in Madrasin cattle with ovarian hypofunction [PDF]
Veterinary World, 2020 Background and Aim: The follicle-stimulating hormone (FSH) gene is an essential regulator of fertility in livestock. This study aims to provide information on the genetic makeup of Madrasin cattle experiencing hypofunction by the FSH profile and FSH ...
Budi Utomo +2 more
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Follicle-stimulating hormone receptor expression in advanced atherosclerotic plaques [PDF]
Scientific ReportsExperimental evidence indicates that follicle-stimulating hormone (FSH), an essential hormone for reproduction, can act directly on endothelial cells inducing atherosclerosis activation and development.
Nicolae Ghinea +4 more
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Structure-Function Relationships of the Follicle-Stimulating Hormone Receptor [PDF]
Frontiers in Endocrinology, 2018 The follicle-stimulating hormone receptor (FSHR) plays a crucial role in reproduction. This structurally complex receptor is a member of the G-protein coupled receptor (GPCR) superfamily of membrane receptors.
Alfredo Ulloa-Aguirre +4 more
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Small Molecule Follicle-Stimulating Hormone Receptor Agonists and Antagonists [PDF]
Frontiers in Endocrinology, 2019 The follicle-stimulating hormone receptor (FSHR) has been targeted therapeutically for decades, due to its pivotal role in reproduction. To date, only purified and recombinant/biosimilar FSH have been used to target FSHR in assisted reproduction, with ...
Ross C. Anderson +3 more
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Discovery and Preclinical Development of Orally Active Small Molecules that Exhibit Highly Selective Follicle Stimulating Hormone Receptor Agonism [PDF]
Frontiers in Pharmacology, 2021 An orally active follicle stimulating hormone receptor allosteric agonist would provide a preferred treatment for over 16 million infertile women of reproductive age in low complexity methods (ovulation induction-intrauterine insemination) or in high ...
Selva Nataraja +4 more
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Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor [PDF]
Nature Communications, 2023 Follicle stimulating hormone (FSH) is a glycoprotein hormone the functions of which are mediated by a G protein-coupled receptor, FSHR. Here, Duan et al.
Jia Duan +14 more
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Endocrine Disruption of the Follicle-Stimulating Hormone Receptor Signaling During the Human Antral Follicle Growth [PDF]
Frontiers in Endocrinology, 2021 An increasing number of pollutants with endocrine disrupting potential are accumulating in the environment, increasing the exposure risk for humans.
Neena Roy +13 more
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Glycoprotein G-protein Coupled Receptors in Disease: Luteinizing Hormone Receptors and Follicle Stimulating Hormone Receptors [PDF]
Diseases, 2020 Signal transduction by luteinizing hormone receptors (LHRs) and follicle-stimulating hormone receptors (FSHRs) is essential for the successful reproduction of human beings.
Duaa Althumairy +6 more
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Membrane Estrogen Receptor (GPER) and Follicle-Stimulating Hormone Receptor (FSHR) Heteromeric Complexes Promote Human Ovarian Follicle Survival [PDF]
iScience, 2020 Summary: Classically, follicle-stimulating hormone receptor (FSHR)-driven cAMP-mediated signaling boosts human ovarian follicle growth and oocyte maturation.
Livio Casarini +25 more
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