Results 71 to 80 of about 253,888 (352)

BHLHE40 Cooperates with GATA2/3 to Control Human Syncytiotrophoblast Lineage Differentiation

Advanced Science, EarlyView.
BHLHE40 interacts directly with GATA2 and GATA3 and co‐occupies genomic loci critical for STB differentiation and function. BHLHE40 also affects GATA2/3 binding at enhancer and promoter regions. Moreover, BHLHE40 is potentially involved in genome‐wide remodeling of H3K4me3 and H3K27ac chromatin landscapes through GATA2/3 recruitment, activating ...
Lijin Peng, Weijie Zhao, Chunfang Xu, Yue Li, Jiani Guo, Taotao Zhou, Philip Chiu, Huimei Wu, Qingyu Wu, Yanxing Wei, Shaorong Gao, Meirong Du   +11 more
wiley   +1 more source

Effect of modified laparoscopic salpingectomy on ovarian reserve: Changes in the serum antimüllerian hormone levels

Laparoscopic, Endoscopic and Robotic Surgery, 2019
Objective: To retrospectively estimate the impact of modified laparoscopic salpingectomy on the ovarian reserve in infertile women. Methods: There were 74 infertile women undergone modified laparoscopic salpingectomy from June 2016 to January 2017, and ...
Dong Huang, Yunshan Zhu, Jianmin Chen, Songying Zhang   +3 more
doaj   +1 more source

Sex-specific regulation of follicle-stimulating hormone secretion by synaptotagmin 9

Nature Communications, 2015
The anterior pituitary releases six different hormones that control virtually all aspects of vertebrate physiology, yet the molecular mechanisms underlying their Ca2+-triggered release remain unknown.
Lindsey K. Roper, Joseph S. Briguglio, Chantell S. Evans, M. Jackson, E. Chapman   +4 more
semanticscholar   +1 more source

Alternative Models for Anticancer Drug Discovery From Natural Products Using Binary Tumor‐Microenvironment‐on‐a‐Chip

Advanced Science, EarlyView.
This study presents a binary tumor‐microenvironment‐on‐a‐chip (T‐MOC) system incorporating multicellular tumor spheroids (MCTs) as an alternative preclinical platform to evaluate the efficacy of anticancer natural products. The T‐MOC model reproduces in vivo drug delivery barriers and physiological conditions, enabling morphological analysis to predict
Youngwon Kim, Si Hyeon Chae, Dahae Lee, Bum Soo Lee, Jiseok Lim, Hyo‐Il Jung, Ki Hyun Kim, Bongseop Kwak   +7 more
wiley   +1 more source

Hepatic KLF9 Deficiency Inhibits Dehydroepiandrosterone (DHEA)‐Induced Polycystic Ovary Syndrome via Liver‐Ovary Axis

Advanced Science, EarlyView.
The study shows that liver is a previously unrecognized extraovarian organ that plays a key role about androgen homeostasis in the development of DHEA‐induced PCOS. DHEA is the most common precursor of active androgen, such as DHT, and KLF9 is required for the conversion of DHEA to DHT and hepatic KLF9 might be a potential therapeutic target for PCOS ...
Jianli Song, Zhaoqing Guan, Guiyi Ji, Jing Wang, Xiurui Yan, Yujie Zhang, Yinliang Zhang, Chunfang Ha, Rong Hu, Yongsheng Chang, Yaolin Zhang, Heng Fan   +11 more
wiley   +1 more source

Acupuncture for hormonal readiness and gut microbiota in obese polycystic ovary syndrome: an open-label, randomized controlled trial

Frontiers in Endocrinology
ObjectiveTo explore whether acupuncture combined with clomiphene can reduce the luteinizing hormone-to follicle-stimulating hormone ratio and impact the gut microbiota in patients with obese polycystic ovary syndrome.MethodsThis open-label, randomized ...
Tianyu Wu, Guixing Xu, Guixing Xu, Guixing Xu, Xiaojuan Hong, Xiaojuan Hong, Huaying Fan, Jiuzhi Zeng, Yu Liu, Jinqun Hu, Fanrong Liang, Fanrong Liang, Jie Yang, Jie Yang, Jiao Chen, Jiao Chen   +15 more
doaj   +1 more source

Bacteria‐Targeted Single‐Atom Nanozyme With Photothermal‐Augmented Multi‐Enzymatic Cascade and NO Delivery for Enhanced Infected Wound Healing

Advanced Science, EarlyView.
A single‐atom nanozyme‐based multifunctional nanoplatform synergizes bacterial targeting with a NIR‐II responsive therapeutic cascade for effective diabetic wound management. This nanoplatform enhances biofilm destruction through photothermal‐augmented biocatalysis while simultaneously activating endothelial cells by delivering nitric oxide to promote ...
Junyang Chen, Qing Chen, Xudong Qin, Haixia Yang, Xin Wang, Jianliang Zhou, Ying‐Wei Yang, Jian Tian   +7 more
wiley   +1 more source

Evidence for Follicle-stimulating Hormone Receptor as a Functional Trimer

Journal of Biological Chemistry, 2014
Background: A carbohydrate of follicle-stimulating hormone (FSH) has been proposed to sterically block other FSH molecules from binding to the putative receptor (FSHR) trimer.
Xuliang Jiang, David J Fischer, Xiaoyan Chen, S. Mckenna, Heli Liu, V. Sriraman, Henry N. Yu, A. Goutopoulos, S. Arkinstall, Xiaolin He   +9 more
semanticscholar   +1 more source

Thermosensory TRPV Heterotetramers Drive Seasonal Polyphenism: Molecular Basis of CcIav/CcNan‐PKCα‐AKH/AKHR Signaling in Pear Psyllid Morph Transition

Advanced Science, EarlyView.
At 2 5 °C, thermal activation initiates: i) CcIav/CcNan heterotetramer assembly → Ca2⁺ influx; ii) CcPKCα phosphorylation → AKH signaling potentiation; iii) CcAKH1 binding to membrane‐localized CcAKHR → energy mobilization (lipid catabolism/glycogenolysis) and vitellogenin transport via follicular patency; iv) Oocyte maturation → summer‐form nymph ...
Jianying Li, Zhixian Zhang, Yilin Wang, Yue Yang, Jiarui Wang, Xueyi Ruan, Songdou Zhang   +6 more
wiley   +1 more source

Interaction of Follicle-Stimulating Hormone and Stem Cell Factor to Promote Primordial Follicle Assembly in the Chicken

Frontiers in Endocrinology, 2019
Follicle-stimulating hormone (FSH) and KIT signaling are required for ovarian development. In this study the interactive effect of FSH and stem cell factor (SCF) on folliculogenesis was investigated in the chicken.
Changquan Guo, Guang Liu, Dan Zhao, Yuling Mi, Caiqiao Zhang, Jian Li   +5 more
doaj   +1 more source