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Differential actions of follistatin and follistatin-like 3
Molecular and Cellular Endocrinology, 2004Follistatin (FS) is an important physiological regulator of activin and other TGFbeta superfamily members. The recently discovered follistatin-like 3 (FSTL3; a.k.a. FLRG; FSRP) shares significant structural and functional homology with FS, but also has some interesting differences, including a prominent nuclear localization.
Elisabetta Del Re +2 more
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Follistatin-related protein (FSRP): a new member of the follistatin gene family
Molecular and Cellular Endocrinology, 2001The identification and characterization of follistatin related protein (FSRP) suggests that the follistatin (FS) gene family may actually contain two sub-families. The first includes FS and FSRP by virtue of their high degree of structural homology and comparable activin-binding activity, while the second sub-family contains extracellular matrix ...
Toshiya Matsuzaki +2 more
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Follistatin: A Multifunctional Regulatory Protein
Frontiers in Neuroendocrinology, 1998Follistatin was first described in 1987 as a follicle-stimulating hormone inhibiting substance present in ovarian follicular fluid. We now know that this effect of follistatin is only one of its many properties in a number of reproductive and nonreproductive systems.
David M De Kretser +2 more
exaly +3 more sources
The International Journal of Biochemistry & Cell Biology, 1998
Follistatin, a secreted protein is able to bind and neutralise the actions of many members of the Transforming Growth Factor-beta family of proteins. Follistatin was first implicated in the regulation of follicle-stimulating hormone secretion in the pituitary and subsequently in other regions of the adult body associated with reproductive functions ...
Tak W. Mak +4 more
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Follistatin, a secreted protein is able to bind and neutralise the actions of many members of the Transforming Growth Factor-beta family of proteins. Follistatin was first implicated in the regulation of follicle-stimulating hormone secretion in the pituitary and subsequently in other regions of the adult body associated with reproductive functions ...
Tak W. Mak +4 more
openaire +3 more sources
Expression patterns of follistatin and two follistatin-related proteins during mouse development [PDF]
The International Journal of Developmental Biology, 2000 We compared the expression patterns of follistatin and two follistatin-related proteins (FRP and m7365) during early mouse development. m7365 is expressed continuously during preimplantation development, in contrast to FRP and follistatin. At early postimplantation stages, follistatin and 7365 are expressed from E6.0, while FRP is detected from E7.5 ...
Groot, E. de +6 more
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Inhibins, activins and follistatins
Journal of Steroid Biochemistry, 1989Inhibins are proteins consisting of two subunits, 18 K alpha- and 14 K beta-subunits, linked by disulfide bonds. Two forms of inhibins A and B consisting of a common alpha-subunit and a similar but distinguishable beta-subunit specifically suppress the secretion and cell content of FSH in a delayed action.
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Activin A and follistatin in systemic inflammation
Molecular and Cellular Endocrinology, 2004Inflammation is a complex process regulated by a cascade of cytokines and growth factors. This review summarizes the emerging evidence implicating activin A and follistatin in the inflammatory process. Our recent studies have highlighted that activin A is released early in the process as part of the circulatory cytokine cascade during acute systemic ...
Jones, Kristian. L. +3 more
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Journal of Bone and Mineral Metabolism, 2012
Mechanical competence of bones is mainly associated with tissue quality that depends on proper bone metabolism processes. An imbalance in the regulation of bone metabolism leads to pathological changes in bone tissue leading to susceptibility to bone fractures and bone deterioration processes.
Anna, Gajos-Michniewicz +3 more
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Mechanical competence of bones is mainly associated with tissue quality that depends on proper bone metabolism processes. An imbalance in the regulation of bone metabolism leads to pathological changes in bone tissue leading to susceptibility to bone fractures and bone deterioration processes.
Anna, Gajos-Michniewicz +3 more
openaire +2 more sources
Follistatin/activin-binding protein
Trends in Endocrinology & Metabolism, 1992Follistatin, or follicle-stimulating hormone (FSH) suppressing protein, is a protein isolated from side fractions in the purification of inhibin and activin, which shares with inhibin the property of suppressing the secretion of FSH from the pituitary gonadotroph. This protein is structurally distinct from inhibin.
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