Results 1 to 10 of about 4,161 (87)

A Dynamic 3D Human Liver Sinusoid Model for Mechanistic Interrogation of Fontan-Associated Liver Disease. [PDF]

Adv Sci (Weinh)
This study presents a perfusable 3D bioengineered liver sinusoid platform that integrates biofabrication, 3D cell culture, controlled hemodynamics, and multiparametric characterization to model Fontan‐associated liver disease. By decoupling pressure and hypoxia effects, the system reveals early mechanobiological and profibrotic responses under ...
Rezapourdamanab S, Amoli MS, Mukherjee T, Bagheri M, Hwang B, Jin L, Singh Y, Norton S, Bongirwar AV, Karnik S, Dasi LP, Avazmohammadi R, Romero R, Bauser-Heaton HD, Serpooshan V.   +14 more
europepmc   +2 more sources

A One-Dimensional (1D) Computational Fluid Dynamics Study of Fontan-Associated Liver Disease (FALD). [PDF]

Int J Numer Method Biomed Eng
Fontan‐associated liver disease (FALD) is a disorder arising from congestion in the liver. This disease is prominent in patients with hypoplastic left heart syndrome (HLHS). Through perfusion analysis, we find that as FALD progresses, there are increased pressures and decreased flow to certain regions of liver tissue.
Li Y, Weigand JD, Puelz C, Olufsen MS, Taylor-Lapole A.   +4 more
europepmc   +2 more sources

5D Flow MRI Reveals Respiration‐Driven Changes in Blood Flow Energetics in Congenital Heart Disease

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Hemodynamic monitoring is essential for patients with right‐sided congenital heart disease (CHD). Respiration may have an increased impact on pulmonary flow in these patients that cannot be assessed by standard tools including 4D flow MRI. This study uses 5D flow MRI to assess respiratory‐cycle variations in flow energetics in patients
Thara Nallamothu, Elizabeth K. Weiss, Justin Baraboo, Joshua D. Robinson, Cynthia K. Rigsby, Christopher W. Roy, Matthias Stuber, Michael Markl   +7 more
wiley   +1 more source

Varicocelectomy Restores Spermatogenesis in Fontan‐Associated Varicocele: A Two‐Case Series

IJU Case Reports, Volume 9, Issue 4, July 2026.
ABSTRACT Introduction Fontan circulation may cause chronic venous hypertension and predispose patients to varicocele and infertility, but the clinical significance of surgical treatment remains unclear. Case Presentation We describe two patients with Fontan circulation who developed Fontan‐associated varicocele (FAVC).
Yusuke Tominaga, Tomoko Kobayashi, Yuko Matsumoto, Takatoshi Moriwake, Nariaki Ozaki, Takuya Sadahira, Satoshi Katayama, Shingo Nishimura, Kensuke Bekku, Motoo Araki   +9 more
wiley   +1 more source

Association of Fontan Circulation With Gut Microbiome Derived Straight and Branched Short Chain Fatty Acids

Journal of Gastroenterology and Hepatology, Volume 41, Issue 6, Page 1825-1836, June 2026.
Adults with Fontan circulation (n = 20) and matched controls underwent body composition, frailty testing, CPET, and NICaS hemodynamics. Plasma short‐chain fatty acids were quantified by LC–MS/MS. Fontan patients had higher straight and branched SCFAs, correlating with lower muscle mass, greater frailty, reduced VO2max, and worse resting/postexercise ...
Ashish H. Shah, Yixiu Liu, Heather K. Armstrong, Jun Han, David R. Goodlett, Amir Ravandi, Sanjiv Dhingra   +6 more
wiley   +1 more source

Computational Modeling Meets 3D Bioprinting: Emerging Synergies in Cardiovascular Disease Modeling

Advanced Healthcare Materials, Volume 15, Issue 17, 8 May 2026.
Emerging advances in three‐dimensional bioprinting and computational modeling are reshaping cardiovascular (CV) research by enabling more realistic, patient‐specific tissue platforms. This review surveys cutting‐edge approaches that merge biomimetic CV constructs with computational simulations to overcome the limitations of traditional models, improve ...
Tanmay Mukherjee, Mehdi Salar Amoli, Sarah Rezapourdamanab, Lama Rita El Shammas, Martin L. Tomov, Emilio A. Mendiola, Vahid Serpooshan, Reza Avazmohammadi   +7 more
wiley   +1 more source

Early‐Onset Digestive System Cancers: Risk Factors and Clinicopathological and Molecular Features Across Organ Sites

Cancer Science, Volume 117, Issue 5, Page 1223-1234, May 2026.
Shared risk factors, clinical features, and tumor characteristics across multiple early‐onset cancer types are shown in this Graphical Abstract. Integrative approaches combining molecular pathology, oncology, and population sciences offer opportunities to clarify underlying mechanisms and help us develop preventive strategies for early‐onset cancers ...
Nobuhiro Nakazawa, Satoko Ugai, Atsushi Kondo, Kosuke Matsuda, Shu Kato, Genki Usui, Shiori Tanaka, Hwa‐Young Lee, Xinyuan Zhang, Hideo Miyagawa, Mai Chan Lau, Hiroshi Saeki, Yukihide Kanemitsu, Andrew T. Chan, Shuji Ogino, Minkyo Song, Juha P. Väyrynen, Tomotaka Ugai   +17 more
wiley   +1 more source

Phenotyping of Fontan‐Associated Renal Physiology and Disease

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
In patients with a Fontan circulation, both kidney function and glomerular injury progressively decline with age, with a stronger decline than in healthy individuals. Additionally, intrarenal haemodynamics in patients with a Fontan circulation demonstrate decreased venous and arterial compliance, evident through elevated venous impedance and renal ...
Gaston van Hassel, Jozine M. ter Maaten, Iris E. Beldhuis, Eryn T. Liem, Bastiaan Zwart, Stephan J. L. Bakker, Rolf M. F. Berger, Joost P. van Melle   +7 more
wiley   +1 more source

REgistry Of Catheter AbLation After Congenital Heart Disease Surgery(REAL‐CHD Registry)

Journal of Arrhythmia, Volume 42, Issue 2, April 2026.
Catheter ablation for postoperative CHD‐related arrhythmias is increasingly performed in Japan and can be achieved with acceptable safety. ABSTRACT Background Advances in surgical management have improved long‐term survival in patients with congenital heart disease (CHD), leading to a growing population of adults with postoperative arrhythmias. However,
Hitoshi Mori, Nobuhiro Nishii, Yoshiaki Kato, Takahiko Kinjo, Tsugutoshi Suzuki, Jun Yoshimoto, Shigeru Tateno, Aya Miyazaki, Hisaaki Aoki, Satoshi Higuchi, Koji Nakagawa, Keiko Toyohara, Daiji Takeuchi, Tetsuri Sakai, Kiyotaka Takefuta, Ryuta Henmi, Masayoshi Mori, Daigo Yagishita, Shun Hasegawa, Yuko Matsui, Shonosuke Watanabe, Kensuke Kikuchi, Kunihiro Kani, Yasunori Hiranuma, Toshiya Matsuyama, Kazuhisa Matsumoto, Masataka Narita, Wataru Sasaki, Taisuke Nabeshima, Kota Nagaoka, Takuro Kojima, Ritsushi Kato, Morio Shoda, Naokata Sumitomo   +33 more
wiley   +1 more source

Comparison of Rifampin and Isoniazid for Latent Tuberculosis Infection in Kidney Transplant Candidates: Focus on Tolerability and Treatment Completion

Transplant Infectious Disease, Volume 28, Issue 2, March/April 2026.
This study comparing 4‐month rifampin with 9‐month isoniazid for latent tuberculosis in kidney transplant candidates showed higher treatment completion rates and no transaminase elevations in the rifampin group. However, some patients experienced an increase in blood pressure while taking antihypertensive medications known to interact with rifampin ...
Jacques Simkins, Julia Bini Viotti, Yoichiro Natori, Shweta Anjan, Adela Mattiazzi, Mariella Ortigosa‐Goggins, Giselle Guerra, David Roth, Warren Kupin, Javier A. Pagan, Franco Cabeza, Gaetano Ciancio, Mahmoud Morsi, Michele I. Morris   +13 more
wiley   +1 more source