Results 11 to 20 of about 4,249 (125)

Severe Fontan-Associated Liver Disease and Its Association With Mortality. [PDF]

J Am Heart Assoc, 2023
Background Data are rare about the incidence of severe Fontan‐associated liver disease (FALD) and its association with mortality. We sought to: (1) estimate the probability of developing severe FALD in patients who undergo the Fontan procedure (Fontan ...
Guerrero-Chalela CE, Therrien J, Grossman Y, Guo L, Liu A, Marelli A.   +5 more
europepmc   +2 more sources

Fontan-Associated Liver Disease: Trends Over Time and Relationship With Outcomes. [PDF]

J Am Heart Assoc
Background Fontan associated liver disease is a poorly understood complication of long‐term single ventricle palliation. This study sought to describe serial liver function changes in patients with a Fontan circulation from 2014 to 2020 and determine if ...
Janzen M, Khakh P, Peng D, Sathananthan G, Kiess M, Chakrabarti S, Grewal J.   +6 more
europepmc   +2 more sources

Fontan-associated liver disease: Diagnosis, surveillance, and management. [PDF]

Front Pediatr, 2023
The Fontan operation is a lifesaving procedure for patients with functional single-ventricle congenital heart disease, where hypoplastic left heart syndrome is the most frequent anomaly.
de Lange C, Möller T, Hebelka H.
europepmc   +2 more sources

Novel immunologic mechanisms for Fontan-associated liver disease. [PDF]

Int J Cardiol Congenit Heart Dis
Introduction: Single ventricle congenital heart disease resulting in Fontan palliation has led to improved survival, however, Fontan-associated liver disease (FALD) is ubiquitous in this population by adulthood. While lymphopenia has been associated with
Angelotti A, Dhesi M, Bansal SS, Bradley EA.   +3 more
europepmc   +2 more sources

Hepatocellular carcinoma diagnosed in a patient who had Fontan operation 30 years ago: a case report [PDF]

Journal of Liver Cancer, 2022
The Fontan operation is performed in patients with a single ventricle. As the systemic venous return is directly connected to the pulmonary circulation during this procedure, chronic hepatic congestion is induced, leading to Fontan-associated liver ...
Moon Haeng Hur, Haeryoung Kim, Jeong-Hoon Lee   +2 more
doaj   +1 more source

Clinical complications of liver disease in adults after the Fontan operation

International Journal of Cardiology Congenital Heart Disease, 2022
Background: The natural history and complications of Fontan-associated liver disease (FALD) are not well-characterized. We aim to describe the incidence and prevalence of and risk factors for adverse liver-related complications in FALD.
Bhavesh Patel, Marina Serper, Emily Ruckdeschel, Sara L. Partington, Lauren Andrade, Lynda Tobin, Yuli Kim, Maarouf A. Hoteit   +7 more
doaj   +1 more source

Fontan‐Associated Dyslipidemia

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Hypocholesterolemia is a marker of liver disease, and patients with a Fontan circulation may have hypocholesterolemia secondary to Fontan‐associated liver disease or inflammation.
Adam M. Lubert, Tarek Alsaied, Joseph J. Palermo, Nadeem Anwar, Elaine M. Urbina, Nicole M. Brown, Craig Alexander, Hassan Almeneisi, Fred Wu, Andrew R. Leventhal, Nael Aldweib, Michael Mendelson, Alexander R. Opotowsky   +12 more
doaj   +1 more source

Fontan-associated Liver Disease in Adults: What a Cardiologist Needs to Know. A Comprehensive Review for Clinical Practitioners. [PDF]

US Cardiol, 2022
Nowadays most patients with a univentricular heart after Fontan repair survive until adulthood. One of the hallmarks of Fontan circulation is permanently elevated central venous pressure, which leads to congestive hepatopathy.
Cieplucha A, Budts W, Gewillig M, Van De Bruaene A.   +3 more
europepmc   +2 more sources

Functional hepatic deterioration determined by 13C-methacetin breath test is associated with impaired hemodynamics and late Fontan failure in adults

Frontiers in Cardiovascular Medicine, 2022
BackgroundDespite improved survival a substantial number of Fontan patients eventually develop late failure. Fontan-associated liver disease (FALD) is the most frequent end-organ dysfunction.
Anastasia Schleiger, Peter Kramer, Hannes Sallmon, Niklas Jentsch, Marta Pileckaite, Friederike Danne, Marie Schafstedde, Marie Schafstedde, Marie Schafstedde, Hans-Peter Müller, Tobias Müller, Frank Tacke, Maximilian Jara, Martin Stockmann, Felix Berger, Felix Berger, Stanislav Ovroutski   +16 more
doaj   +1 more source

Hepatic Steatosis in Patients With Single Ventricle and a Fontan Circulation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Hepatic steatosis, caused by nonalcoholic fatty liver disease, is a leading cause of chronic liver disease. The interplay between hepatic steatosis and the development of liver disease following the Fontan procedure is not well understood ...
David A. Katz, Daniel Peck, Adam M. Lubert, Mathias Possner, Faizeen Zafar, Andrew T. Trout, Joseph J. Palermo, Nadeem Anwar, Jonathan R. Dillman, Adam W. Powell, Stavra A. Xanthakos, Alexander R. Opotowsky, Gruschen Veldtman, Tarek Alsaied   +13 more
doaj   +1 more source