Results 1 to 10 of about 4,230 (104)

Severe Fontan‐Associated Liver Disease and Its Association With Mortality [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Data are rare about the incidence of severe Fontan‐associated liver disease (FALD) and its association with mortality. We sought to: (1) estimate the probability of developing severe FALD in patients who undergo the Fontan procedure (Fontan ...
Carlos‐Eduardo Guerrero‐Chalela, Judith Therrien, Yoni Grossman, Liming Guo, Aihua Liu, Ariane Marelli   +5 more
doaj   +4 more sources

Fontan-associated liver disease: Diagnosis, surveillance, and management [PDF]

Frontiers in Pediatrics, 2023
The Fontan operation is a lifesaving procedure for patients with functional single-ventricle congenital heart disease, where hypoplastic left heart syndrome is the most frequent anomaly.
Charlotte de Lange, Charlotte de Lange, Thomas Möller, Hanna Hebelka, Hanna Hebelka   +4 more
doaj   +4 more sources

Fontan‐Associated Liver Disease: Trends Over Time and Relationship With Outcomes [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Fontan associated liver disease is a poorly understood complication of long‐term single ventricle palliation. This study sought to describe serial liver function changes in patients with a Fontan circulation from 2014 to 2020 and determine if ...
Mikyla Janzen, Parm Khakh, Defen Peng, Gnalini Sathananthan, Marla Kiess, Santabhanu Chakrabarti, Jasmine Grewal   +6 more
doaj   +2 more sources

Fontan-Associated Liver Disease: A Review

Annals of Hepatology, 2018
Fontan-associated liver disease is a hepatic disorder arising from hemodynamic changes and systemic venous congestion following Fontan surgery. The histological changes produced in the liver are similar but not equivalent to those seen in other forms of ...
Luis Téllez, Enrique Rodríguez-Santiago, Agustín Albillos   +2 more
doaj   +3 more sources

Novel immunologic mechanisms for Fontan-associated liver disease [PDF]

International Journal of Cardiology Congenital Heart Disease
Introduction: Single ventricle congenital heart disease resulting in Fontan palliation has led to improved survival, however, Fontan-associated liver disease (FALD) is ubiquitous in this population by adulthood. While lymphopenia has been associated with
Austin Angelotti, Maninder Dhesi, Shyam S. Bansal, Elisa A. Bradley   +3 more
doaj   +2 more sources

Fontan-associated Liver Disease in Adults: What a Cardiologist Needs to Know. A Comprehensive Review for Clinical Practitioners [PDF]

US Cardiology Review, 2022
Nowadays most patients with a univentricular heart after Fontan repair survive until adulthood. One of the hallmarks of Fontan circulation is permanently elevated central venous pressure, which leads to congestive hepatopathy.
Aleksandra Cieplucha, Werner Budts, Marc Gewillig, Alexander Van De Bruaene   +3 more
doaj   +2 more sources

Non-invasive fibrosis tools lack clinical utility for identifying advanced fibrosis in Fontan-associated liver disease: a retrospective cohort study [PDF]

BMJ Open Gastroenterology
Objective Fontan-associated liver disease (FALD) results from haemodynamic changes following the Fontan procedure for congenital heart disease and is associated with poorer outcomes.
Stephen Stewart, Robert Hughes, Kevin Walsh, Paul Armstrong, Aoife Moriarty, Niamh Mehigan, Rhona Savage, Jennifer Russell   +7 more
doaj   +2 more sources

Non-invasive Investigations for the Diagnosis of Fontan-Associated Liver Disease in Pediatric and Adult Fontan Patients

Frontiers in Cardiovascular Medicine, 2017
Fontan-associated liver disease (FALD) is a serious complication related to the chronically elevated venous pressure and low cardiac output of this abnormal circulation. However, diagnostic markers for this condition are limited.
Amyna Fidai, Frederic Dallaire, Nanette Alvarez, Yvonne Balon, Robin Clegg, Robin Clegg, Michael Connelly, Frank Dicke, Deborah Fruitman, Joyce Harder, Kimberley Myers, David J. Patton, David J. Patton, Tim Prieur, Erika Vorhies, Robert P. Myers, Steven R. Martin, Steven C. Greenway, Steven C. Greenway   +18 more
doaj   +3 more sources

Comprehensive Multiomic Analysis Reveals Metabolic Reprogramming Underlying Human Fontan‐Associated Liver Disease [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The Fontan operation is the current standard of care for single‐ventricle congenital heart disease. Almost all patients with Fontan operation develop liver fibrosis at a young age, known as Fontan‐associated liver disease (FALD).
Rasheed Sule, Po Hu, Clarissa Shoffler, Christopher Petucci, Benjamin J. Wilkins, Jack Rychik, Liming Pei   +6 more
doaj   +2 more sources

Doppler ultrasound and 2D shear wave ultrasound elastography for liver fibrosis evaluation in Fontan-associated liver disease [PDF]

BMC Gastroenterology
Background The Fontan operation improves survival in patients with single ventricle physiology but is associated with Fontan-associated liver disease (FALD), characterized by progressive fibrosis due to prolonged elevated central venous pressure.
Nakarin Inmutto, Attaporn Jantarangkoon, Natthapong Nimitrungtawee, Nattaporn Sriwicha, Sarawut Kongkarnka, Saviga Sethasathien, Tanop Srisuwan   +6 more
doaj   +2 more sources