Results 181 to 190 of about 646,771 (327)

Elemene Augments the Effects of Anti‐PD‐1 Immunotherapy on Hepatocellular Carcinoma by Regulating the miR‐130a‐5p/SPP/MHC‐I Axis

Advanced Science, EarlyView.
Elemene increases SPP expression by competitively binding with miR‐130a‐5p to suppress SPP mRNA degradation. This led to more antigen/MHC‐I complexes being expressed on the cell surface, which consequently facilitated the recognition and killing of HCC cells by CTLs and enhancing the antitumor immune efficacy of anti‐PD‐1.
Menglan Wang, Mengqing Sun, Heng Dong, Xiaoting Zhang, Jingbo Zhang, Zhengguo Zhang, Mengjie Ni, Lina Li, Yunxin Pei, Xiaoyu Chen, Qian Li, Fangtian Bu, Jiacheng Huang, Liangyu Jiang, Zhuting Fang, Xuliang Chen, Jianxiang Chen, Yiting Qiao, Tian Xie   +18 more
wiley   +1 more source

Mapping Socioecological Interconnections in One Health Across Human, Animal, and Environmental Health: A Scoping Review Protocol. [PDF]

Int J Environ Res Public Health
Medeiros JFD, Santos LMP, Silva SM, Barreto JOM, Galdino JPDS, Vale EFN, Santos Mercedes KD, Costa MSD, Fleck JM, Almeida KSM, Ginani VC, Araújo WN, Queiroz DV, Pacheco C.   +13 more
europepmc   +1 more source

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

Advanced Science, EarlyView.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia, Rebecca Parodi‐Rullan, Rafael Vazquez‐Torres, Ashley Carey, Huaqing Zhao, Sabzali Javadov, Silvia Fossati   +6 more
wiley   +1 more source

Predicting the spatio-temporal risk of human tick-borne encephalitis (TBE) in Europe by combining hazard and exposure drivers. [PDF]

One Health
Dagostin F, Erazo D, Marini G, Da Re D, Tagliapietra V, Avdicova M, Avšič-Županc T, Dub T, Fiorito N, Knap N, Gossner CM, Kerlik J, Mäkelä H, Markowicz M, Olyazadeh R, Richter L, Wint W, Zuccali MG, Žygutienė M, Dellicour S, Rizzoli A.   +20 more
europepmc   +1 more source

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

Advanced Science, EarlyView.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du, Rui Deng, Ya Wu, Hong‐Xia Ren, Zong‐Hong Lin, Yang‐Bao Miao   +5 more
wiley   +1 more source

Editorial: Recent advances in vector-borne diseases and climate change. [PDF]

Front Microbiol
Hussain M, Yu Y, Wang L, Qureshi JA.
europepmc   +1 more source

Foodborne trematodes: a diverse and challenging group of neglected parasites [PDF]

, 2017
Blair, Doanh, Joanne P. Webster, Kamsa-ard, Lai, Paiboon Sithithaworn, Pakharukova, Pérez-Ponce de León, Ross H. Andrews, Saijuntha, Tantrawatpan, Toledo, Trevor N. Petney, Valero   +13 more
core   +1 more source

Impact of food and water-borne diseases on European population health

, 2016
Alessandro Cassini, E. Colzani, P. Kramarz, M. Kretzschmar, J. Takkinen   +4 more
semanticscholar   +1 more source

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

Using participatory epidemiology to understand differences in tick-borne disease perceptions from homeowners in the Ohio River valley. [PDF]

One Health
Bache EG, Matzkin P, Fleming J, Pesapane R, Tufts DM.   +4 more
europepmc   +1 more source