Results 101 to 110 of about 3,144,653 (281)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Food addiction

, 2019
Introdução: A obesidade é um factor de risco modificável com crescente impacto global na morbilidade e mortalidade. A eficácia de medidas para prevenir e tratar a obesidade, como o Programa Nacional para a Promoção da Alimentação Saudável da Direcção-Geral de Saúde, está ainda por estabelecer.
openaire   +3 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Exercise addiction – the emergence of a new disorder [PDF]

, 2014
An optimal level of regular physical activity plays an important role in the maintenance of physical and mental health. However, excessive exercise in a minority of individuals can have adverse effects on health and lead to exercise addiction.
Demetrovics, Zsolt, Szabó, Attila, Berczik, K, Griffiths, MD, Kökönyei, Gyöngyi, Szabó, A, Kurimay, T, Urbán, R, Kökönyei, G, Urbán, Róbert, Demetrovics, Z, Kurimay, Tamás, Berczik, Krisztina, Griffiths, Mark   +13 more
core  

COMPARISON OF PHYSICAL ACTIVITY LEVEL AND FOOD ADDICTION OF PHYSICAL EDUCATION AND SPORTS SCIENCE COLLEGE STUDENTS [PDF]

Sportif Bakış Spor ve Eğitim Bilimleri Dergisi, 2017
The aim of this study is to examine the physical activity level and food addiction of physical education and sport science students and to investigate the excessive food consumption. In the study in order to evaluate food addiction of students “Yale Food
Mert Kayhan, Alparslan Ünveren
doaj  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Emotion and Stress Related Eating and Personality Dimensions Predict Food Addiction: Implications for Personalized Weight Management and Primary Prevention

Mediterranean Journal of Clinical Psychology
Background: Food addiction constitutes a novel health concern with potential consequences for both psychological and physical well-being. While the etiology of Food addiction is likely multifactorial, additional factors beyond obesogenic environments ...
Eva Klanduchova, Lucia Adamovska
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Understanding food addiction through the lens of psychological well-being, self-control, and eating behavior: a cross-sectional study

Journal of Eating Disorders
Objective This study aimed to elucidate how psychological distress, self-control, and sustainable healthy eating behaviors interact to shape food addiction, by simultaneously modeling their direct and indirect effects in adult population. Methods A cross-
Murat Açik, Taha Gökmen Ülger
doaj   +1 more source