Results 101 to 110 of about 5,531,710 (302)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Optimization, Validation, and Application of Cleanup-Coupled Liquid Chromatography–Tandem Mass Spectrometry for the Simultaneous Analyses of 35 Mycotoxins and Their Derivatives in Cereals

open access: yesFoods
Mycotoxins occur singly or as co-contaminants and are primarily present in carbohydrate-rich foods such as cereals and cereal-based products. To effectively monitor mycotoxin co-contamination in cereals and cereal-based products, the simultaneous ...
Dan-Bi Kim   +3 more
doaj   +1 more source

Some neglected issues in food demand analysis: retail-level demand, health information and product quality [PDF]

open access: yes
Food demand analysis is dominated by the econometric estimation of demand systems based on aggregate market data and steady progress has been made in analytical techniques. Yet some issues have been neglected in food demand analysis which are crucial for
Herrmann, Roland, Roeder, Claudia
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

From Single Constituents to Metabolomics in Food Quality Analysis [PDF]

open access: yes, 2013
Until now, a wide range of laboratory approaches has been employed for control of organic food quality and authenticity. In addition to widely used light isotope measurement based methods, various spectroscopic and/or chromatographic have been ...
Hajslova, Jana, Schulzova, Vera
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Can Survey-based Scenarios Measure Consumer Values for Improved Food Safety? [PDF]

open access: yes
Demand and Price Analysis, Food Consumption/Nutrition/Food Safety,
Bockstael, Nancy E.   +5 more
core   +1 more source

vinegar soup improved his womb : Food, Appetite, and the Redefining of Asian American Masculinity in Kingston\u27s China Men [PDF]

open access: yes, 2013
This paper examines the connection between food, appetite, and gender identity in Maxine Hong Kingston\u27s China Men. Specifically, I argue that Kingston\u27s use of food in China Men reconstructs traditional norms of masculinity.
Crawford, Danielle
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Application of Sorbent-Based Extraction Techniques in Food Analysis. [PDF]

open access: yesMolecules, 2023
Drabińska N   +3 more
europepmc   +1 more source

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