Results 101 to 110 of about 2,359,182 (307)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

IMPACT Projections of Food Production, Consumption, and Hunger to 2050, With and Without Climate Change: Extended Country-level Results for 2019 GFPR Annex Table 5 [PDF]

open access: yes, 2018
Policy makers, analysts, and civil society face increasing challenges to reducing hunger and improving food security in a sustainable way. Modeling alternative future scenarios and assessing their outcomes can help inform policy choices.
International Food Policy Research Institute (IFPRI)
core   +1 more source

Esters of 3-chloropropane-1,2-diol in foodstuffs

open access: yesCzech Journal of Food Sciences, 2004
We provide here for the first time the evidence that 3-chloropropane-1,2-diol (3-MCPD) occurs in foodstuffs in its free form and also in the form of esters with higher fatty acids.
B. Svejkovská   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Genetic modification and food quality a down to earth analysis [PDF]

open access: yes, 2015
"This book will present a scientific analysis of how genetic engineering of plants and other food sources affects the quality and safety of food for humans"-
Blair, Robert 1933-, Regenstein, J. M.
core  

Bioactive compounds in palm oil: A comprehensive review of recent advances in physicochemical characteristics, health-promoting properties and technologies for extraction, concentration, fractionation, encapsulation and functional food applications [PDF]

open access: yes
Tocotrienols and ß-carotene, along with other bioactive compounds in palm oil, are known for their health-promoting properties. These compounds are underutilized in functional applications.
Cortes-Prieto C.-M   +9 more
core   +1 more source

Alkaline Reaction Pathways of Phenolic Compounds with β-Lactoglobulin Peptides: Polymerization and Covalent Adduct Formation

open access: yesMolecules
A common strategy for a protein’s functionality modification is the covalent binding of phenolic compounds (PCs) under alkaline conditions. Whether intentionally applied or arising during food processing and storage, such reactions are highly relevant ...
Alina Bock   +5 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Changes in Egg Volatiles during Storage

open access: yesCzech Journal of Food Sciences, 2002
The quality of eggs is tightly associated with freshness. New possibilities for the determination of egg freshness were studied. The volatile compounds of eggs and their changes during storage were followed. Three methods for extraction of volatiles were
J. Adamiec   +3 more
doaj   +1 more source

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