Results 111 to 120 of about 1,015,538 (309)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Biofortification of UK food crops with selenium [PDF]

, 2006
Se is an essential element for animals. In man low dietary Se intakes are associated with health disorders including oxidative stress-related conditions, reduced fertility and immune functions and an increased risk of cancers.
Broadley, MR, Fang-jie Zhao, Zhao, Fang-Jie, Hawkesford, Malcolm J., Bryson, R. J., Zhao, F-J., Harriman, M., Tucker, M., Bowen, HC, Bowen, H. C., Miles Harriman, Harriman, Miles, Meacham, Mark C., Meacham, M. C., Broadley, Martin R., McGrath, S. P., Bryson, RJ, Broadley, M. R., Zhao, FJ, Helen C. Bowen, Martin R. Broadley, Steve P. Mcgrath, Tucker, M, Neil Breward, White, P. J., Malcolm J. Hawkesford, McGrath, Steve P., McGrath, SP, Johnson, S. E., Philip J. White, Meacham, MC, Bryson, Rosie J., Rosie J. Bryson, Johnson, Sarah E., Harriman, M, White, Philip J., Breward, N., Johnson, SE, Hawkesford, MJ, White, PJ, Mark C. Meacham, Bowen, Helen C., Mark Tucker, Hawkesford, M. J., Tucker, Mark, Breward, Neil, Sarah E. Johnson   +46 more
core   +1 more source

Animal health and food safety [PDF]

British Medical Bulletin, 2000
Foods of animal origin have an important role in a balanced diet and must be safe for human consumption. Equally important is the need for the food to be perceived as safe by the consumer. Safe food of animal origin must be free from animal pathogens that infect man and from contamination by residues.
openaire   +2 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Antibiotic resistance and virulence of faecal enterococci isolated from food-producing animals in Tunisia [PDF]

, 2015
Antimicrobial agents exert a selection pressure not only on pathogenic, but also on commensal bacteria of the intestinal tract of humans and animals. The aim of this work was to determine the occurrence of different enterococcal species and to analyse ...
Klibi, A., N. Klibi, R. Aouini, Ben Sallem, R., Ben Said, L., C. Torres, K. Ben Slama, Klibi, N., C. Ferrario, A. Boudabous, Dziri, R. [0000-0003-1783-5672], F. Borgo, R. Dziri, Torres, C. [0000-0003-3709-1690], Boudabous, A., Ben Slama, K. [0000-0001-5745-3930], L. Ben Said   +16 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Method to evaluate the microbial degradation activity in silage, cow rumen with in vitro test, and in manure and slurry

MethodsX
Microorganisms are present everywhere and can influence a variety of processes. In agriculture and husbandry, the level of microbial activity can be crucial information, yet the methods for determining microbial activity are usually very long, complex ...
Nebojša Nikolić, Selene Massaro, Franco Tagliapietra, Andrea Squartini, Stefano Schiavon, Roberta Masin   +5 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Gender differences in delay-discounting under mild food restriction [PDF]

, 2009
: Impulsivity, a core symptomof attention-deficit hyperactivity disorder (ADHD), is tested in animal models by delay-discounting tasks. So far, mainly male subjects have been used in this paradigm at severe levels of food restriction. Here we studied the
Koot, S., Emotion and Cognition, Adriani, W., van den Bos, R., Laviola, G., Dep of Animals in Science and Society   +5 more
core  

Maize RNA PolIV affects the expression of genes with nearby TE insertions and has a genome-wide repressive impact on transcription

BMC Plant Biology, 2017
Background RNA-directed DNA methylation (RdDM) is a plant-specific epigenetic process that relies on the RNA polymerase IV (Pol IV) for the production of 24 nucleotide small interfering RNAs (siRNA) that guide the cytosine methylation and silencing of ...
Cristian Forestan, Silvia Farinati, Riccardo Aiese Cigliano, Alice Lunardon, Walter Sanseverino, Serena Varotto   +5 more
doaj   +1 more source