Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto +11 more
wiley +1 more source
Genetic Adaptation of Mesorhizobium Symbionts Associated With Caragana in Northern China Deserts. [PDF]
Yuan X, Li H, Yu X, Ji Z.
europepmc +1 more source
Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li +16 more
wiley +1 more source
Drylands Under Pressure: Responses of Insect Density to Land-Use Change in a Tropical Desert. [PDF]
Pati A, Paul I, Dutta S.
europepmc +1 more source
Trait-mediated linkages and stocking rate thresholds in plant-community-soil feedbacks to long-term grazing in a <i>Stipa breviflora</i> desert steppe. [PDF]
Li J +7 more
europepmc +1 more source
The impact of food insecurity on chronic liver disease: A systematic review of the literature. [PDF]
Elias LM +4 more
europepmc +1 more source
Food insecurity and health outcomes in a USDA identified food desert
Karlena Brailey
openalex +1 more source
Neuroprotective Effects of Desert Milk Exosomes in LPS-Induced Cognitive Decline: Role of Microglial M2 Polarization and AMPK Signaling. [PDF]
Li Y +11 more
europepmc +1 more source
Grocery Shopping Habits in a Rural Food Desert
Ryan Pesch, Rani A Bhattacharyya
openalex +1 more source

