Results 231 to 240 of about 11,988 (256)

Integrated Single‐Cell and Spatial Analysis Reveals a Metabolic‐Immune Axis Driving Aortic Dissection

Advanced Science, EarlyView.
Single‐cell and spatial profiling of 110 human thoracic aortic samples reveals a stromal–immune circuit driving aortic dissection. An elastin‐rich fibroblast subset is depleted with age and markedly reduced in disease, weakening aortic wall integrity.
Jing Tao, Huanjie Yang, Jiahui Yong, Xueting Chen, Qiang Zhao, Xueli Wu, Lei Yan, Li Pang, Fan Luo, Mengjun Yu, Shanshan Pan, Deyang Li, Rouxi Chen, Juan Wang, Zhensheng Dong, Fan Yang, Yue Wang, Yang Chen, Hongjian Zheng, Zhimin Yang, Zijie Wang, Karsten Kristiansen, Hui Peng, Xiaodong Fang, Juan Shen, Yining Yang   +25 more
wiley   +1 more source

GLS1 Orchestrates Exosome‐Mediated Tumor‐Endothelial Communication to Facilitate Angiogenesis

Advanced Science, EarlyView.
This study reveals a previously unappreciated, non‐metabolic function of GLS1 in the control of tumor angiogenesis via exosome‐mediated CAV1‐TNC signaling, indicating that therapeutic targeting of GLS1 may offer a dual benefit by simultaneously suppressing tumor metabolic activity and angiogenic processes in head and neck cancer. ABSTRACT Glutaminase 1
Jianqiang Yang, Zhenzhen Fu, Fanghui Chen, Soumya Vijaya Kumar, Fan Yang, Yaochao Zheng, Yunqi Li, Yao Yao, Nabil F. Saba, Yong Teng   +9 more
wiley   +1 more source

Light‐Switched Mesenchymal Stem Cells for In Situ Exosome Amplification in Craniofacial Bone Defect Reconstruction

Advanced Science, EarlyView.
Light‐switchable MSCs (MSC‐UCNPs) were constructed by intracellular incorporation of UCNPs. Upon 980 nm irradiation, UCNPs emitted localized ultraviolet light (365 nm), activating the ROS/HEXB/LAMP1 signaling pathway to suppress lysosome–multivesicular body fusion and thereby enhance exosome biogenesis. Embedded within an injectable hydrogel, MSC‐UCNPs
Tingting Wu, Yajing Liu, Shuman Wang, Xiaoming Bai, Luyun Zhang, Yuwei Liu, Zhiwen Fu, Chen Shi   +7 more
wiley   +1 more source

High‐Performance Prevascularized SHED‐Laden rGO@Hydrogel Achieves Optimized Diabetic Bone Defect Repair

Advanced Science, EarlyView.
A high‐performance 3D scaffold integrating rGO and SHEDs is developed to overcome impaired healing in diabetic bone defects. By driving extracellular matrix remodeling, rGO creates a pro‐angiogenic niche that significantly accelerates in vitro vascular network formation.
Can Zhang, Yiyuan Kang, Shulin Lai, Chunyi Wang, Guixin He, Kehui Jian, Suhan Yin, Xiner Tan, Xinru Zhou, Wenjing Liu, Fujian Zhao, Jia Liu, Longquan Shao   +12 more
wiley   +1 more source

Cobalt Single‐Atom Catalysts for Ultrafast Sulfamethoxazole Degradation: Unveiling the Chloride‐Ion‐Enhanced Formation of Co(IV)=O

Advanced Science, EarlyView.
An atomically dispersed Co–N4 single‐atom catalyst rapidly activates peroxymonosulfate to remove the antibiotic sulfamethoxazole from water. Common ions have little impact, but chloride dramatically speeds degradation by promoting a high‐valent Co(IV) = O oxidant via in situ HOCl–catalyst electron transfer.
Anting Ding, Jing Lu, Yafei Fan, Chenyu Zeng, Yuhang Lin, Yufei Shi, Zulin Zhang   +6 more
wiley   +1 more source

Stress‐to‐Light Conversion in an Earth‐Abundant Oxide Semiconductor

Advanced Science, EarlyView.
Stress‐to‐light conversion in solids represents a unique photonic functionality, yet it has never been realized in a chemically simple and sustainable material. Here, we show that sustainable semiconductor ZnO exhibits strong near‐infrared (NIR) luminescence under elastic stress when defect‐engineered to stabilize the p‐type state.
Tomoki Uchiyama, Koki Otonari, Reona Omori, Guangfa Yang, Eiji Nishibori, Ying Chen, Xu‐Guang Zheng, Chao‐Nan Xu   +7 more
wiley   +1 more source

Dual‐Stage Microneedle Patch With Lipid Droplet‐Mediated ‘Capture‐Kill’ and Sustained Release for Enhanced Wound Healing

Advanced Science, EarlyView.
We report a lipid‐droplet‐engineered, gallium‐loaded sonodynamic therapeutic platform (LDTG) incorporated into a bilayer microneedle (MN) patch co‐delivering all‐trans retinoic acid (ATRA), termed LDTG A‐MNs, for synergistic antibacterial therapy and accelerated wound repair.
Peng Jiang, Meijun Jiang, Jiapeng Lei, Wen Zhang, Huiyuan Yang, Xueyang Wang, Siyu Zhang, Qiongfang Ruan, Shuhua Liu, Wei Li   +9 more
wiley   +1 more source