Results 91 to 100 of about 460,086 (309)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Diversity, Ethnobotanical Knowledge, and Cultural Food Significance of Edible Plants Traded in an Urban Market in Baise City, China

Diversity
Urban markets are key nodes for the persistence and adaptation of traditional edible plant knowledge, linking rural production with urban consumption. This study was based on monthly market surveys conducted throughout 2025 in an urban market in Baise ...
Yuefeng Zhang, Bin Huang, Wei Shen, Lingling Lv, Xiangtao Cen, Piyaporn Saensouk, Thawatphong Boonma, Surapon Saensouk, Tammanoon Jitpromma   +8 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Diversity and Ethnobotanical Knowledge of Spice Plants and Pickled Vegetables in Youjiang District, Baise City, Guangxi, China

Diversity
Spices and pickled vegetables play a central role in everyday cuisine in China, contributing to flavor, food preservation, and dietary continuity, yet their ethnobotanical diversity and use patterns remain insufficiently documented in urbanizing regions.
Wei Shen, Bin Huang, Yuefeng Zhang, Xiangtao Cen, Lingling Lv, Piyaporn Saensouk, Phiphat Sonthongphithak, Surapon Saensouk, Tammanoon Jitpromma   +8 more
doaj   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Enfoque alimentario para mejorar la adecuación nutricional de vitaminas y minerales

Archivos Latinoamericanos de Nutrición, 2001
Usando como base la densidad de nutrientes y los planteamientos de las guías alimentarias basadas en alimentos (gaba), se explora la adecuación nutricional de patrones alimentarios constituidos por los alimentos básicos más relevantes en el ámbito ...
María-Teresa Oyarzún, Ricardo Uauy, Sonia Olivares   +2 more
doaj  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

From home garden to market: ethnobotanical insights from Jīn Sān Jiǎo Agricultural Market, Baise City, Guangxi, China

Journal of Ethnobiology and Ethnomedicine
Background Baise City in Guangxi, China, is a culturally and ecologically diverse region where traditional plant knowledge persists despite ongoing urbanization.
Yuefeng Zhang, Bin Huang, Wei Shen, Lingling Lv, Piyaporn Saensouk, Thawatphong Boonma, Tammanoon Jitpromma, Surapon Saensouk   +7 more
doaj   +1 more source

Ethnobotany of Food Plants Traded in Renmin Market, Youjiang District, Baise City, China

Diversity
Traditional markets play an important role in the exchange of plant resources and the preservation of traditional food knowledge. This study documents the diversity of food plants traded in Renmin Market, located in Youjiang District, Baise City, Guangxi,
Bin Huang, Wei Shen, Yuefeng Zhang, Junle Niu, Lingling Lv, Xiangtao Cen, Piyaporn Saensouk, Thawatphong Boonma, Surapon Saensouk, Tammanoon Jitpromma   +9 more
doaj   +1 more source