Results 121 to 130 of about 1,592,305 (263)

Assessment of Pharmacokinetics and Food Effect of AD-109, a Novel Formulation of Rivaroxaban 18 mg. [PDF]

Clin Transl Sci
Ryu H, Cho JY, Lee T, Kim J, Lee S.
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

First-in-human safety, tolerability, pharmacokinetics and pilot food-effect study of the candidate antimalarial compound MMV367. [PDF]

Br J Clin Pharmacol
Kuemmerle A, Singh N, Gossen D, Janin A, Sharma R, Cahn A, Gibson RA, Menakuru SR, Lambourne E, Dove T, Gamo FJ, Sanz L, Bestgen B, Chalon S.   +13 more
europepmc   +2 more sources

On the effectiveness of private food standards

, 2010
This paper provides an original theoretical framework to better understand the raise of private quality standards in agrifood chains. Reasons for the development and conditions for the effectiveness of private quality standards are identified, by investigating firms’ strategic behaviour and, more precisely, both interactions among processing/retailing ...
Giraud-Heraud, Eric, Grazia, Cristina, Hammoudi, Abdelhakim   +2 more
openaire   +4 more sources

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

A randomized, open-label, two-way crossover clinical trial to evaluate the food effect on pharmacokinetics and safety of DHP107 in patients with advanced solid tumors: the FEEL study. [PDF]

Cancer Chemother Pharmacol
Hitre E, Láng I, Páll D.
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Risks encountered when not adjusting for diurnal variation and food effect in QTcF analysis based on phase I data. [PDF]

J Pharmacokinet Pharmacodyn
Bardol M, Henrich A, Sarr C, Mezzalana E, Langenhorst J.   +4 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Using a PBPK Model Incorporating Lymphatic Absorption to Predict Food Effect, Multiple Dosing, and Hepatic Impairment of Cannabidiol. [PDF]

Clin Transl Sci
Qian L, Zhou Z.
europepmc   +1 more source