Results 61 to 70 of about 31,268,655 (339)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

LOCAL EFFECTS OF DELAYED FOOD [PDF]

Journal of the Experimental Analysis of Behavior, 2007
Five pigeons were trained on a procedure in which seven concurrent variable‐interval schedules arranged seven different food‐rate ratios in random sequence in each session. Each of these components lasted for 10 response‐produced food deliveries, and components were separated by 10‐s blackouts.
Michael, Davison, William M, Baum
openaire   +2 more sources

A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosphodiesterase Type 5 Inhibitor, in Healthy Subjects

Drug Design, Development and Therapy, 2021
Hongjie Qian,1,2 Qian Chen,1,2 Liyu Liang,1,2 Yang Zou,1,2 Huahua Pu,1,2 Liang Xin,1,2 Rong Song,1,2 Tingting Li,1,2 Huijuan Zhu,1,2 Yu Wang,3 Guanghui Tian,4 Jingshan Shen,2,3 Hualiang Jiang,2,3 Chen Yu,1,2 Zhen Wang,2,3 Jingying Jia1,2 1Central ...
Qian H, Chen Q, Liang L, Zou Y, Pu H, Xin L, Song R, Li T, Zhu H, Wang Y, Tian G, Shen J, Jiang H, Yu C, Wang Z, Jia J   +15 more
doaj  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

A phase I study to evaluate the safety, tolerability, and pharmacokinetics of HEC113995PA·H2O, a novel dual-acting serotonergic antidepressant, in healthy subjects

Frontiers in Pharmacology
PurposeHEC113995PA·H2O is a novel, potent and selective serotonin (5-HT) reuptake inhibitor and a 5-HT1A receptor partial agonist, and thus is categorized as a serotonin partial agonist-reuptake inhibitor.
Xue Wu, Xue Wu, Xue Wu, Qingqing Wu, Qingqing Wu, Qingqing Wu, Qichen Ding, Qichen Ding, Qichen Ding, Yulei Zhuang, Lin Luo, Yingjun Zhang, Li Deng, Chuanfei Jin, Xue Li, Zhangma Huang, Haiping Qin, Liang Xin, Liang Xin, Liang Xin, Qian Chen, Qian Chen, Qian Chen, Jingying Jia, Jingying Jia, Jingying Jia, Yanmei Liu, Yanmei Liu, Yanmei Liu   +28 more
doaj   +1 more source

Nymph and Adult Performance of the Small Green Stink Bug, Piezodorus guildinii (Westwood) on Lanceleaf Crotalaria and Soybean

Brazilian Archives of Biology and Technology, 2002
Lanceleaf crotalaria, Crotalaria lanceolata E. Mey (Leguminosae) was found hosting the small green stink bug, Piezodorus guildinii (Westwood), in Paraná State, Brazil.
Antônio Ricardo Panizzi, Shirlei Regina Cardoso, Viviane Ribeiro Chocorosqui   +2 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Food safety in Finland 2020 [PDF]

, 2021
This report presents the 2020 results of regulatory control related to food safety, official controls and monitoring programmes on food and feed as well as research and risk assessments.
Finnish Food Authority
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source