Results 51 to 60 of about 1,592,305 (263)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Multiple Ascending Dose and Food Effect Study to Evaluate the Tolerance, Pharmacokinetics of Jaktinib, a New Selective Janus Kinase Inhibitor in Healthy Chinese Volunteers

Frontiers in Pharmacology, 2020
Background: Jaktinib is a novel selective janus kinase 1/2 inhibitor. The phase I first-in-human study evaluated the tolerance and pharmacokinetics of jaktinib in healthy Chinese subjects.Methods: A randomized, double-blind, placebo-controlled study were
Jingrui Liu, Binhua Lv, Hewen Yin, Xiaoxue Zhu, Haijing Wei, Yanhua Ding   +5 more
doaj   +1 more source

Effect of Food on the Bioavailability of Prednisone [PDF]

The Journal of Clinical Pharmacology, 1976
Two commercial prednisone tablets were studied which had previously been shown by Sullivan et al.5,6 to have the slowest and fastest in vitro rates of dissolution, and the slowest and fastest rise to peak plasma prednisolone concentrations in human beings. The effect of food on the adsorption of these two tablets was studied in a crossover study, which
Tembo, Aubrey V., Sakmar, Ermelinda, Hallmark, Margarette R., Weidler, Donald J., Wagner, John G.   +4 more
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

LOCAL EFFECTS OF DELAYED FOOD [PDF]

Journal of the Experimental Analysis of Behavior, 2007
Five pigeons were trained on a procedure in which seven concurrent variable‐interval schedules arranged seven different food‐rate ratios in random sequence in each session. Each of these components lasted for 10 response‐produced food deliveries, and components were separated by 10‐s blackouts.
Michael, Davison, William M, Baum
openaire   +2 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Glycoprotein Non‐Metastatic Melanoma Protein B (GPNMB): A Translational Pharmacodynamic Biomarker for PIKfyve Inhibition With VRG50635

Clinical and Translational Science
Glycoprotein non‐metastatic melanoma protein B (GPNMB) was investigated as a pharmacodynamic (PD) biomarker for PIKfyve inhibition across translational studies ex vivo, in vitro, in animals, and in the clinic, demonstrating significant response to ...
Geraldine Gontier, Grace Kim, Chao Wang, Kevin Zhu, Raymond Gau, Ningzhe Zhang, Swati Naphade, Alistair Stewart, Martin J. Schmidt, Robert Galemmo, Brian Shook, Anil Tarachandani, Irene Choi, Shane Raines, Robert H. Scannevin, Henrieke W. Grievink, Lars M. G. Smits, Philip H. C. Kremer, Diego Cadavid   +18 more
doaj   +1 more source

Food effects on tablet disintegration

European Journal of Pharmaceutical Sciences, 2004
The aims of the present study was to investigate if food components, as represented by a multi-component nutritional drink for tube feeding, could affect tablet disintegration of standard tablets in vitro as well as in vivo and propose a mechanism for potential food effects on tablet disintegration.
Bertil, Abrahamsson, Tamsin, Albery, Anna, Eriksson, Ingrid, Gustafsson, Marie, Sjöberg   +4 more
openaire   +2 more sources