Results 1 to 10 of about 20,264 (293)
Development and application of a physiologically-based pharmacokinetic model for ractopamine in goats [PDF]
Frontiers in Veterinary SciencePhysiologically Based Pharmacokinetic (PBPK) models can provide forecasts of the drug residues within the organism. Ractopamine (RAC) is a typical β-agonist. In this study, we developed a PBPK model for RAC in goats.
Jing Ai +8 more
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MEGen: A Physiologically Based Pharmacokinetic Model Generator [PDF]
Frontiers in Pharmacology, 2011 Physiologically based pharmacokinetic models are being used in an increasing number of different areas. These not only include the human safety assessment of pharmaceuticals, pesticides, biocides and environmental chemicals but also for food animal, wild
George D Loizou, Alex eHogg
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Human physiologically based pharmacokinetic model for propofol [PDF]
BMC Anesthesiology, 2005 Background Propofol is widely used for both short-term anesthesia and long-term sedation. It has unusual pharmacokinetics because of its high lipid solubility.
Schnider Thomas W, Levitt David G
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Asian Journal of Pharmaceutical Sciences, 2017 The aim of the present study was to investigate virtual population pharmacokinetic using physiologically based pharmacokinetic (PBPK) model for evaluating bioequivalence of oral lacidipine formulations in dogs.
Bin Yang +6 more
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Physiologically Based Pharmacokinetic Model for Prediction of Immunoglobulins Exposure in Pregnant Women [PDF]
AntibodiesBackground: Physiologically based pharmacokinetic (PBPK) modeling is applied to address clinical pharmacology issues including dose selection and exposure assessments for special populations (e.g., pediatrics, and renally or hepatically impaired patients)
Million A. Tegenge
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Comprehensive Physiologically Based Pharmacokinetic Model to Assess Drug–Drug Interactions of Phenytoin [PDF]
Pharmaceutics, 2023 Regulatory agencies worldwide expect that clinical pharmacokinetic drug–drug interactions (DDIs) between an investigational new drug and other drugs should be conducted during drug development as part of an adequate assessment of the drug’s safety and ...
Leyanis Rodriguez-Vera +7 more
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Physiologically‐based pharmacokinetic model of sparsentan to evaluate drug–drug interaction potential [PDF]
CPT: Pharmacometrics & Systems PharmacologySparsentan is a dual endothelin/angiotensin II receptor antagonist indicated to reduce proteinuria in patients with primary IgA nephropathy at high risk of disease progression. In vitro data indicate that sparsentan is likely to inhibit or induce various
Nikunjkumar K. Patel +3 more
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Corrigendum: Development and application of a physiologically-based pharmacokinetic model for ractopamine in goats [PDF]
Frontiers in Veterinary ScienceJing Ai +8 more
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Frontiers in Pharmacology, 2022 Pharmacokinetic (PK) modeling is a useful method for investigating drug absorption, distribution, metabolism, and excretion. The most commonly used mathematical models in PK modeling are the compartment model and physiologically based pharmacokinetic ...
Hyo-jeong Ryu +7 more
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Pharmaceutics, 2023 The bioequivalence of bempedoic acid oral suspension and commercial immediate release (IR) tablet formulations were assessed using a physiologically based pharmacokinetic (PBPK) model.
Benny M. Amore +6 more
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