Results 1 to 10 of about 31,417,318 (246)

Physiologically Based Pharmacokinetic Model Development and Verification for Bioequivalence Testing of Bempedoic Acid Oral Suspension and Reference Tablet Formulation

Pharmaceutics, 2023
The bioequivalence of bempedoic acid oral suspension and commercial immediate release (IR) tablet formulations were assessed using a physiologically based pharmacokinetic (PBPK) model.
Benny M. Amore, Nikunjkumar Patel, Priya Batheja, Ian E. Templeton, Hannah M. Jones, Michael J. Louie, Maurice G. Emery   +6 more
doaj   +3 more sources

A Physiologically-Based Pharmacokinetic Model to Predict Posaconazole Suspension Exposure and Optimize Dosing Strategy in Pediatric Hematology Patients: Incorporating the Impact of Food Intake [PDF]

Drug Design, Development and Therapy
Juan Wu,1 Xia Qin,2 Xiaohang Huang,2 Dengyu Wang,1 Cheng Jin,1 Shiying Huang,1 Zhuo Li,1 Manman Liu11Department of Pharmacy Administration, Shanghai Children’s Medical Center, School of Medicine, Shanghai JiaoTong University, Shanghai, People’s Republic ...
Wu J, Qin X, Huang X, Wang D, Jin C, Huang S, Li Z, Liu M   +7 more
doaj   +2 more sources

Virtual population pharmacokinetic using physiologically based pharmacokinetic model for evaluating bioequivalence of oral lacidipine formulations in dogs

Asian Journal of Pharmaceutical Sciences, 2017
The aim of the present study was to investigate virtual population pharmacokinetic using physiologically based pharmacokinetic (PBPK) model for evaluating bioequivalence of oral lacidipine formulations in dogs.
Bin Yang, Chunnuan Wu, Bin Ji, Mingrui Wu, Zhonggui He, Lei Shang, Jin Sun   +6 more
doaj   +3 more sources

Physiologically Based Pharmacokinetic Model for Prediction of Immunoglobulins Exposure in Pregnant Women [PDF]

Antibodies
Background: Physiologically based pharmacokinetic (PBPK) modeling is applied to address clinical pharmacology issues including dose selection and exposure assessments for special populations (e.g., pediatrics, and renally or hepatically impaired patients)
Million A. Tegenge
doaj   +2 more sources

Development and application of a physiologically-based pharmacokinetic model for ractopamine in goats [PDF]

Frontiers in Veterinary Science
Physiologically Based Pharmacokinetic (PBPK) models can provide forecasts of the drug residues within the organism. Ractopamine (RAC) is a typical β-agonist. In this study, we developed a PBPK model for RAC in goats.
Jing Ai, Yunfeng Gao, Fan Yang, Zhen Zhao, Jin Dong, Jing Wang, Shiyi Fu, Ying Ma, Xu Gu   +8 more
doaj   +2 more sources

Corrigendum: Development and application of a physiologically-based pharmacokinetic model for ractopamine in goats [PDF]

Frontiers in Veterinary Science
Jing Ai, Yunfeng Gao, Fan Yang, Zhen Zhao, Jin Dong, Jing Wang, Shiyi Fu, Ying Ma, Xu Gu   +8 more
doaj   +2 more sources

A compatibility evaluation between the physiologically based pharmacokinetic (PBPK) model and the compartmental PK model using the lumping method with real cases

Frontiers in Pharmacology, 2022
Pharmacokinetic (PK) modeling is a useful method for investigating drug absorption, distribution, metabolism, and excretion. The most commonly used mathematical models in PK modeling are the compartment model and physiologically based pharmacokinetic ...
Hyo-jeong Ryu, Won-ho Kang, Taeheon Kim, Jae Kyoung Kim, Jae Kyoung Kim, Kwang-Hee Shin, Jung-woo Chae, Hwi-yeol Yun   +7 more
doaj   +1 more source

In Silico and In Vivo Pharmacokinetic Evaluation of 84-B10, a Novel Drug Candidate against Acute Kidney Injury and Chronic Kidney Disease

Molecules, 2023
Acute kidney injury (AKI) and chronic kidney disease (CKD) have become public health problems due to high morbidity and mortality. Currently, drugs recommended for patients with AKI or CKD are extremely limited, and candidates based on a new mechanism ...
Man Su, Xianru Liu, Yuru Zhao, Yatong Zhu, Mengqiu Wu, Kun Liu, Gangqiang Yang, Wanhui Liu, Lin Wang   +8 more
doaj   +1 more source

Physiologically based pharmacokinetic-pharmacodynamic evaluation of meropenem in CKD and hemodialysis individuals

Frontiers in Pharmacology, 2023
Objective: Chronic kidney disease (CKD) has significant effects on renal clearance of drugs. The application of antibiotics in CKD patients to achieve the desired therapeutic effect is challenging.
Guoliang Deng, Guoliang Deng, Fan Yang, Ning Sun, Danhong Liang, Danhong Liang, Anfen Cen, Anfen Cen, Chen Zhang, Chen Zhang, Suiqin Ni, Suiqin Ni   +11 more
doaj   +1 more source

Diagnostic biomarker kinetics: how brain-derived biomarkers distribute through the human body, and how this affects their diagnostic significance: the case of S100B

Fluids and Barriers of the CNS, 2022
Blood biomarkers of neurological diseases are often employed to rule out or confirm the presence of significant intracranial or cerebrovascular pathology or for the differential diagnosis of conditions with similar presentations (e.g., hemorrhagic vs ...
Robert Murcko, Nicola Marchi, Damian Bailey, Damir Janigro   +3 more
doaj   +1 more source