Results 31 to 40 of about 31,417,318 (246)

A computational model of the hypothalamic - pituitary - gonadal axis in female fathead minnows (Pimephales promelas) exposed to 17α-ethynylestradiol and 17β-trenbolone [PDF]

, 2011
© 2011 Li et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Watanabe, Karen H, Watanabe, KH, Mitchell Kostich, Villeneuve, DL, Kostich, M, Li, Zhenhong, Zhenhong Li, Sepúlveda, MS, Jensen, Kathleen M, Villeneuve, Daniel L, Daniel L Villeneuve, María S Sepúlveda, Gerald T Ankley, Kathleen M Jensen, Ankley, GT, Nancy D Denslow, Kroll, KJ, Brandon Armstrong, James M Lazorchak, Brian, JV, Brian, Jayne V, Orlando, Edward F, Denslow, ND, Orlando, EF, Ankley, Gerald T, Armstrong, B, Lazorchak, JM, Sepulveda, Maria S, Jayne V Brian, Karen H Watanabe, Lazorchak, James M, Li, Z, Edward F Orlando, Kroll, Kevin J, Jensen, KM, Denslow, Nancy D, Kostich, Mitchell, Armstrong, Brandon, Kevin J Kroll   +38 more
core   +1 more source

Immunomodulatory Effects of Atractylodes lancea in Healthy Volunteers with Dosage Prediction for Cholangiocarcinoma Therapy: A Modelling Approach

Pharmaceuticals
Background and Aims: According to a recent study on the immunomodulatory activity of Atractylodes lancea (Thunb.) DC. (AL) in healthy Thai subjects, AL significantly inhibited the production of key pro-inflammatory cytokines while stimulating the ...
Teerachat Saeheng, Juntra Karbwang, Kesara Na-bangchang   +2 more
doaj   +1 more source

ATLAS mPBPK: A MATLAB‐Based Tool for Modeling and Simulation of Minimal Physiologically‐Based Pharmacokinetic Models

CPT: Pharmacometrics & Systems Pharmacology, 2019
Minimal physiologically‐based pharmacokinetic (mPBPK) models are frequently used to model plasma pharmacokinetic (PK) data and utilize and yield physiologically relevant parameters. Compared with classical compartment and whole‐body physiologically‐based
Panteleimon D. Mavroudis, Vivaswath S. Ayyar, William J. Jusko   +2 more
doaj   +1 more source

Food Effects on Oral Drug Absorption: Application of Physiologically-Based Pharmacokinetic Modeling as a Predictive Tool

Pharmaceutics, 2020
The bioavailability of an orally administered small molecule is often dictated by drug-specific physicochemical characteristics and is influenced by many biological processes.
Lisa Cheng, Harvey Wong
doaj   +1 more source

A physiologically based kinetic model for the prediction of plasma cholesterol concentrations in mice and man [PDF]

, 2011
An increased plasma cholesterol concentration is associated with increased risk of cardiovascular disease. However, individuals vary largely in their response to cholesterol lowering drugs and 40% of them, do not reach their cholesterol-lowering target.
van de Pas, N., Pas, N., van de
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Adapting Physiologically-Based Pharmacokinetic Models for Machine Learning Applications

, 2023
Materials (code, data files) associated with the paper ' Adapting Physiologically-Based Pharmacokinetic Models for Machine Learning Applications
Reisfeld, Brad, Habiballah, Sohaib
core   +2 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source