Results 31 to 40 of about 20,264 (293)
Pharmaceutics, 2021 Malnutrition in children is a global health problem, particularly in developing countries. The effects of an insufficient supply of nutrients on body composition and physiological functions may have implications for drug disposition and ultimately affect
Erik Sjögren +3 more
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Unraveling bisphenol A pharmacokinetics using physiologically based pharmacokinetic modeling [PDF]
Frontiers in Pharmacology, 2015 Physiologically based pharmacokinetic (PBPK) models integrate both chemical- and system-specific information into a mathematical framework, offering a mechanistic approach to predict the internal dose metrics of a chemical and an ability to perform species and dose extrapolations.
Yang, Xiaoxia, Fisher, Jeffrey W.
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Frontiers in Pharmacology, 2020 Vicagrel, a novel acetate derivative of clopidogrel, exhibits a favorable safety profile and excellent antiplatelet activity. Studies aim at identifying genetic and non-genetic factors affecting vicagrel metabolic enzymes Cytochrome P450 2C19 (CYP2C19 ...
Shuaibing Liu +3 more
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Frontiers in Pharmacology, 2022 Biowaiver based on the biopharmaceutics classification system (BCS) has been widely used in the global market for the approval of new generic drug products to avoid unnecessary in vivo bioequivalence (BE) studies.
Xian Zhang +7 more
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Pharmaceutics, 2022 Doxorubicin (DOX) is still an important anticancer agent despite its tricky pharmacokinetics (PK) and toxicity potential. The advent of systems pharmacology enables the construction of PK models able to predict the concentration profiles of drugs and ...
George A. Mystridis +2 more
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Pharmaceutics, 2021 Fexuprazan is a new drug candidate in the potassium-competitive acid blocker (P-CAB) family. As proton pump inhibitors (PPIs), P-CABs inhibit gastric acid secretion and can be used to treat gastric acid-related disorders such as gastroesophageal reflux ...
Yoo-Seong Jeong +6 more
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PharmaceuticalsBackground/Objectives: Spatholobi Caulis (SPC) is a medicinal plant that mainly grows in China and Southeast Asian countries and commonly used in clinics; the pharmacokinetic characteristics in humans need to be determined.
Xiaoyan Liu +7 more
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CPT: Pharmacometrics & Systems Pharmacology, 2019 Minimal physiologically‐based pharmacokinetic (mPBPK) models are frequently used to model plasma pharmacokinetic (PK) data and utilize and yield physiologically relevant parameters. Compared with classical compartment and whole‐body physiologically‐based
Panteleimon D. Mavroudis +2 more
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A computational model of the hypothalamic - pituitary - gonadal axis in female fathead minnows (Pimephales promelas) exposed to 17α-ethynylestradiol and 17β-trenbolone [PDF]
, 2011 © 2011 Li et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Watanabe, Karen H +38 more
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PharmaceuticalsBackground and Aims: According to a recent study on the immunomodulatory activity of Atractylodes lancea (Thunb.) DC. (AL) in healthy Thai subjects, AL significantly inhibited the production of key pro-inflammatory cytokines while stimulating the ...
Teerachat Saeheng +2 more
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