Results 11 to 20 of about 20,264 (293)
A Physiologically Based Pharmacokinetic Model for Capreomycin [PDF]
Antimicrobial Agents and Chemotherapy, 2012 ABSTRACTThe emergence of multidrug-resistant tuberculosis (MDR-TB) has led to a renewed interest in the use of second-line antibiotic agents. Unfortunately, there are currently dearths of information, data, and computational models that can be used to help design rational regimens for administration of these drugs.
B, Reisfeld +5 more
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A physiologically based pharmacokinetic model for ionic silver and silver nanoparticles
International Journal of Nanomedicine, 2013 Gerald Bachler, Natalie von Goetz, Konrad Hungerbühler ETH Zurich, Institute for Chemical and Bioengineering, Zurich, Switzerland Abstract: Silver is a strong antibiotic that is increasingly incorporated into consumer products as a bulk, salt, or ...
Bachler G +2 more
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International Journal of Nanomedicine, 2016 Ulrika Carlander,1 Dingsheng Li,2 Olivier Jolliet,2 Claude Emond,3,4 Gunnar Johanson1 1Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; 2Department of Environmental Health Sciences, School of Public Health, University of ...
Carlander U +4 more
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Physiologically based pharmacokinetic (PBPK) modeling and simulation in drug discovery and development [PDF]
ADMET and DMPK, 2019 Physiologically based pharmacokinetic (PBPK) modeling is a mechanistic or physiology based mathematical modeling technique which integrates the knowledge from both drug-based properties including physiochemical and biopharmaceutical properties and system
Abdul Naveed Shaik, Ansar Ali Khan
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PLoS Computational Biology, 2016 Developing physiologically-based pharmacokinetic (PBPK) models for chemicals can be resource-intensive, as neither chemical-specific parameters nor in vivo pharmacokinetic data are easily available for model construction.
Jingtao Lu +12 more
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Physiologically based pharmacokinetic (PBPK) model of chlorzoxazone
, 2023 This repository provides the chlorzoxazone physiologically based pharmacokinetic (PBPK) model. If you have any questions or problems please open an issue FundingMatthias König were supported by the Federal Ministry of Education and Research (BMBF ...
Küttner, Jonas, König, Matthias
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Physiologically Based Pharmacokinetic Modeling of Nanoparticles [PDF]
Journal of Pharmaceutical Sciences, 2019 Nanoparticles are frequently designed to improve the pharmacokinetics profiles and tissue distribution of small molecules to prolong their systemic circulation, target specific tissue, or widen the therapeutic window. The multifunctionality of nanoparticles is frequently presented as an advantage but also results in distinct and complicated in vivo ...
Dongfen, Yuan +4 more
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Molecules, 2023 Acute kidney injury (AKI) and chronic kidney disease (CKD) have become public health problems due to high morbidity and mortality. Currently, drugs recommended for patients with AKI or CKD are extremely limited, and candidates based on a new mechanism ...
Man Su +8 more
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Physiologically Based Pharmacokinetic (PBPK) Models for Ethanol [PDF]
IEEE Transactions on Biomedical Engineering, 2008 Physiologically based pharmacokinetic models have been used to describe the distribution and elimination of ethanol after intravenous administration. These models have been used to estimate the ethanol infusion profile that is sufficient for achieving a prescribed breath ethanol concentration time course in individuals, providing a useful platform for ...
Martin H. Plawecki +4 more
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A minimal physiologically based pharmacokinetic model for high-dose methotrexate [PDF]
, 2021 Purpose: High-dose methotrexate (HDMTX) is administered for the treatment of a variety of malignant tumors. Wide intra- and inter-individual variabilities characterize the pharmacokinetics of MTX, which is mostly excreted renally.
Pesenti, G., Manca, D., Foppoli, M.
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