Results 1 to 10 of about 19,867 (161)
MEGen: A Physiologically Based Pharmacokinetic Model Generator [PDF]
Frontiers in Pharmacology, 2011 Physiologically based pharmacokinetic models are being used in an increasing number of different areas. These not only include the human safety assessment of pharmaceuticals, pesticides, biocides and environmental chemicals but also for food animal, wild
George D Loizou, Alex eHogg
doaj +3 more sources
Pharmaceutics, 2023 The bioequivalence of bempedoic acid oral suspension and commercial immediate release (IR) tablet formulations were assessed using a physiologically based pharmacokinetic (PBPK) model.
Benny M. Amore +6 more
doaj +3 more sources
Human physiologically based pharmacokinetic model for propofol [PDF]
BMC Anesthesiology, 2005 Background Propofol is widely used for both short-term anesthesia and long-term sedation. It has unusual pharmacokinetics because of its high lipid solubility.
Schnider Thomas W, Levitt David G
doaj +3 more sources
A Physiologically-Based Pharmacokinetic Model to Predict Posaconazole Suspension Exposure and Optimize Dosing Strategy in Pediatric Hematology Patients: Incorporating the Impact of Food Intake [PDF]
Drug Design, Development and TherapyJuan Wu,1 Xia Qin,2 Xiaohang Huang,2 Dengyu Wang,1 Cheng Jin,1 Shiying Huang,1 Zhuo Li,1 Manman Liu11Department of Pharmacy Administration, Shanghai Children’s Medical Center, School of Medicine, Shanghai JiaoTong University, Shanghai, People’s Republic ...
Wu J +7 more
doaj +2 more sources
Asian Journal of Pharmaceutical Sciences, 2017 The aim of the present study was to investigate virtual population pharmacokinetic using physiologically based pharmacokinetic (PBPK) model for evaluating bioequivalence of oral lacidipine formulations in dogs.
Bin Yang +6 more
doaj +3 more sources
Physiologically Based Pharmacokinetic Model for Prediction of Immunoglobulins Exposure in Pregnant Women [PDF]
AntibodiesBackground: Physiologically based pharmacokinetic (PBPK) modeling is applied to address clinical pharmacology issues including dose selection and exposure assessments for special populations (e.g., pediatrics, and renally or hepatically impaired patients)
Million A. Tegenge
doaj +2 more sources
Development and application of a physiologically-based pharmacokinetic model for ractopamine in goats [PDF]
Frontiers in Veterinary SciencePhysiologically Based Pharmacokinetic (PBPK) models can provide forecasts of the drug residues within the organism. Ractopamine (RAC) is a typical β-agonist. In this study, we developed a PBPK model for RAC in goats.
Jing Ai +8 more
doaj +2 more sources
Frontiers in Pharmacology, 2022 Pharmacokinetic (PK) modeling is a useful method for investigating drug absorption, distribution, metabolism, and excretion. The most commonly used mathematical models in PK modeling are the compartment model and physiologically based pharmacokinetic ...
Hyo-jeong Ryu +7 more
doaj +1 more source
Corrigendum: Development and application of a physiologically-based pharmacokinetic model for ractopamine in goats [PDF]
Frontiers in Veterinary ScienceJing Ai +8 more
doaj +2 more sources
A Physiologically Based Pharmacokinetic Model for Capreomycin [PDF]
Antimicrobial Agents and Chemotherapy, 2012 ABSTRACTThe emergence of multidrug-resistant tuberculosis (MDR-TB) has led to a renewed interest in the use of second-line antibiotic agents. Unfortunately, there are currently dearths of information, data, and computational models that can be used to help design rational regimens for administration of these drugs.
B, Reisfeld +5 more
openaire +2 more sources