Results 31 to 40 of about 31,268,655 (339)

Bioequivalence and Pharmacokinetic Profiles of Generic and Branded Obeticholic Acid in Healthy Chinese Subjects Under Fasting and Fed Conditions

Drug Design, Development and Therapy, 2021
Meng-Na Wang,1,* Hai-Tao Yu,2,* Ya-Qian Li,1 Yun Zeng,1 Shuang Yang,3 Guo-Ping Yang,1,3– 6 Qi Pei,6 Jie Huang1,3 1Center for Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, People’s ...
Wang MN, Yu HT, Li YQ, Zeng Y, Yang S, Yang GP, Pei Q, Huang J   +7 more
doaj  

Food effect on pharmacokinetics of cannabidiol oral capsules in adult patients with refractory epilepsy

Epilepsia, 2019
To evaluate the pharmacokinetics of a purified oral cannabidiol (CBD) capsule administered with and without food in adults with refractory epilepsy.
A. Birnbaum, Ashwin Karanam, Susan E. Marino, Christopher M. Barkley, R. Remmel, Michaela Roslawski, Mary Gramling-Aden, I. Leppik   +7 more
semanticscholar   +1 more source

Light Effects on Food

Journal of Food Protection, 1990
Current research studies carried out on light-induced changes in dairy products, fats and oils, and meat products are reviewed. General factors affecting thus formed off-flavors in these food groups are the intensity of light, exposure interval, type of packaging, and some specific nutritive constituents.
openaire   +3 more sources

Development of Bioactive Carboxymethyl Cellulose-Based Films via Dual Crosslinking with Citric Acid and X-Ray Irradiation

Foods
This study developed biodegradable carboxymethyl cellulose (CMC) films crosslinked with citric acid (CA) and X-ray irradiation as sustainable packaging alternatives to reduce plastic use. CMC/CA films were subjected to three doses of X-ray irradiation at
Jumana Mahmud, Juan Heredia, Muhammed R. Sharaby, Lily Jaiswal, Stephane Salmieri, Seyedeh Elmira Moosavi, Monique Lacroix   +6 more
doaj   +1 more source

Development and Validation a UPLC-MS/MS Method for Quantification of Pentoxifylline in Beagle Plasma: Application for Pharmacokinetic Study of Food Effect

Drug Design, Development and Therapy, 2023
Yuxiang Xu, Xiaonan Gao, Yunfang Zhu, Qi Zhang, Hongxin Qie, Haopeng Zhao, Jinglin Gao, Mingxia Wang Department of Clinical Pharmacology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, People’s Republic of ChinaCorrespondence ...
Xu Y, Gao X, Zhu Y, Zhang Q, Qie H, Zhao H, Gao J, Wang M   +7 more
doaj  

Prediction of bioequivalence and food effect using flux and solubility based methods.

Molecular Pharmaceutics, 2019
In this paper two different approaches have been developed to predict the food effect and the bioequivalence of marketed itraconazole (ITRA) formulations.
E. Borbás, Szabina Kádár, K. Tsinman, Oksana Tsinman, Dóra Csicsák, K. Takács-Novák, G. Völgyi, B. Sinkó, H. Pataki   +8 more
semanticscholar   +1 more source

Food effects on tablet disintegration

European Journal of Pharmaceutical Sciences, 2004
The aims of the present study was to investigate if food components, as represented by a multi-component nutritional drink for tube feeding, could affect tablet disintegration of standard tablets in vitro as well as in vivo and propose a mechanism for potential food effects on tablet disintegration.
Bertil, Abrahamsson, Tamsin, Albery, Anna, Eriksson, Ingrid, Gustafsson, Marie, Sjöberg   +4 more
openaire   +2 more sources

Effect of a high‐fat and high‐calorie food on the pharmacokinetics of a novel, potent GABA analog HSK16149 in healthy subjects

Pharmacology Research & Perspectives, 2023
HSK16149 is a novel, potent gamma‐aminobutyric acid (GABA) analog for the treatment of neuropathic pain. The purpose of this study was to assess the effect of a high‐fat and high‐calorie meal on the pharmacokinetics of HSK16149 in healthy Chinese ...
Qingqing Wu, Huijuan Zhu, Rong Song, Mengqi Zhang, Fangqiong Li, Weifang Zeng, Wei Wang, Jingying Jia, Chen Yu, Yanmei Liu   +9 more
doaj   +1 more source

Bioequivalence and food effect of a fixed‐dose combination of macitentan and tadalafil: Adaptive design in the COVID‐19 pandemic

Pharmacology Research & Perspectives, 2021
The COVID‐19 pandemic has forced clinical studies to accommodate imposed limitations. In this study, the bioequivalence part could not be conducted as planned.
Dénes Csonka, Vladislav Fishman, Jaya Natarajan, Hans Stieltjes, Danielle Armas, Victor Dishy, Juan Jose Perez Ruixo   +6 more
doaj   +1 more source

Integration of a Physiologically Based Pharmacokinetic and Pharmacodynamic Model for Tegoprazan and Its Metabolite: Application for Predicting Food Effect and Intragastric pH Alterations

Pharmaceutics, 2022
A physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) model for tegoprazan and its major metabolite M1 was developed to predict PK and PD profiles under various scenarios. The PBPK model for tegoprazan and M1 was developed and predicted using
Hyeon-Cheol Jeong, Min-Gul Kim, Zhuodu Wei, Kyeong-Ryoon Lee, Jaehyeok Lee, Im-Sook Song, Kwang-Hee Shin   +6 more
doaj   +1 more source