Results 11 to 20 of about 31,268,655 (339)

Diets, Foods and Food Components’ Effect on Dyslipidemia [PDF]

Nutrients, 2021
Hypercholesterolemia is a well-known independent risk factor for cardiovascular disease and a recognized target of pharmacological therapeutic agents in both primary and secondary prevention [...]
Federica Fogacci, Claudio Borghi, Arrigo F. G. Cicero   +2 more
openaire   +2 more sources

A Non-Nutritive Feeding Intervention Alters the Expression of Efflux Transporters in the Gastrointestinal Tract

Pharmaceutics, 2021
Intestinal interactions with nutrients, xenobiotics and endogenous hormones can influence the expression of clinically relevant membrane transporters.
Yang Mai, Francesca K. H. Gavins, Liu Dou, Jing Liu, Farhan Taherali, Manal E. Alkahtani, Sudaxshina Murdan, Abdul W. Basit, Mine Orlu   +8 more
doaj   +1 more source

Pharmacokinetics and Bioequivalence of Rasagiline Tablets in Chinese Healthy Subjects Under Fasting and Fed Conditions: An Open, Randomized, Single-Dose, Double-Cycle, Two-Sequence, Crossover Trial

Frontiers in Pharmacology, 2020
Objective: This study evaluated the pharmacokinetics, safety, and bioequivalence (BE) of two formulations of rasagiline tablets in healthy Chinese subjects under fasting and fed conditions.Methods: An open, randomized, single-dose, double-cycle, two ...
Yinjuan Li, Lu Qi, Haihong Bai, Ying Liu, Rongxia Fan, Yongrui Tu, Yongqiang Sun, Juxiang Wang, Qi Qi, Xiaohui Feng, Da Zhou, Xinghe Wang   +11 more
doaj   +1 more source

Stability of Flavan-3-ols, Theaflavins, and Methylxanthines in 30 Industrial Green, Black, and White Tea (Camellia sinensis L.) Extracts Characterized via Liquid Chromatography Techniques

Antioxidants, 2023
Commercially available tea extracts for dietary supplements and nutraceuticals are standardized to characteristic components of Camellia sinensis L., such as epigallocatechin gallate (EGCG) and total catechins or polyphenols.
Antonio M. Inarejos-Garcia, Julia Heil, Sonia Guilera Bermell, Gertrud E. Morlock   +3 more
doaj   +1 more source

Safety, tolerability, pharmacokinetics and pharmacodynamics of a novel farnesoid X receptor (FXR) agonist-TQA3526 in healthy Chinese volunteers: a double-blind, randomized, placebo-controlled, dose-escalation, food effect phase I study

Annals of Medicine, 2023
Background: TQA3526 is a novel farnesoid X receptor agonist developed to treat non-alcoholic steatohepatitis (NASH) or primary biliary cholangitis (PBC).
Jia Xu, Hong Zhang, Hong Chen, Xiaoxue Zhu, Haiyan Jia, Zhongnan Xu, Dandan Huo, Hong Zhang, Cuiyun Li, Yanhua Ding   +9 more
doaj   +1 more source

Synthesis and Physicochemical Evaluation of Entecavir-Fatty Acid Conjugates in Reducing Food Effect on Intestinal Absorption

Molecules, 2018
The oral bioavailability of entecavir (EV), an anti-viral agent commonly prescribed to treat hepatitis B infections, is drastically reduced under a post-prandial state. This is primarily due to its low permeability in the gastrointestinal tract.
Hyuck Jun Jung, Myoung Jin Ho, Sungwan Ahn, Young Taek Han, Myung Joo Kang   +4 more
doaj   +1 more source

Pharmacokinetic characteristics of golidocitinib, a highly selective JAK1 inhibitor, in healthy adult participants

Frontiers in Immunology, 2023
BackgroundGolidocitinib is an orally available, potent and highly selective JAK (Janus kinase)-1 inhibitor of JAK/STAT3 signaling under clinical development for the treatment of cancer and autoimmune diseases.
Kan Chen, Xiaoduo Guan, Xiaoduo Guan, Zhenfan Yang, Yue Zhou, Ziyi Liu, Xueyuan Deng, Donghong Liu, Pei Hu, Pei Hu, Rui Chen, Rui Chen   +11 more
doaj   +1 more source

Food safety in Finland 2021 [PDF]

, 2022
This report presents the 2021 results of regulatory control related to food safety, official controls and monitoring programmes on food and feed, as well as research and risk assessments.
Finnish Food Authority, Finnish Food Authority
core  

A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Multiple Dose, and Food Effect Trial of the Safety, Tolerability and Pharmacokinetics of Highly Purified Cannabidiol in Healthy Subjects

CNS Drugs, 2018
BackgroundA formal single ascending and multiple dose pharmacokinetic (PK) trial of cannabidiol (CBD) oral solution was required to determine the safety and tolerability of CBD, the maximum tolerated dose, and to examine the effect of food on CBD PK ...
L. Taylor, B. Gidal, G. Blakey, Bola Tayo, Gilmour Morrison   +4 more
semanticscholar   +1 more source

Effect of Food on the Pharmacokinetics of Quizartinib [PDF]

Clinical Pharmacology in Drug Development, 2020
AbstractQuizartinib is an oral, highly potent, and selective type II FMS‐like tyrosine kinase 3 inhibitor in development for acute myeloid leukemia. This parallel‐group study evaluated potential food effects on quizartinib absorption in healthy subjects who received a single 30‐mg dose after overnight fasting (n = 34) or a high‐fat, high‐calorie meal ...
Li, Jianke, Holmes, Melissa, Kankam, Martin, Trone, Denise, Mendell, Jeanne, Gammon, Guy   +5 more
openaire   +2 more sources