Results 11 to 20 of about 4,794,869 (310)

High-fat diets enhance and delay ursodeoxycholic acid absorption but elevate circulating hydrophobic bile salts

Frontiers in Pharmacology, 2023
Background: Ursodeoxycholic acid (UDCA) is a natural drug essential for the treatment of cholestatic liver diseases. The food effects on the absorption of UDCA and the disposition of circulating bile salts remain unclear despite its widespread global ...
Liang Huang, Liang Huang, Wei Wei, Xiaomei Huang, Xuejing Li, Haisha Liu, Lanlan Gui, Lanlan Gui, Jinping Jiang, Linfei Wan, Xiangxiang Zhou, Jingsong Ding, Xuehua Jiang, Bikui Zhang, Ke Lan, Ke Lan   +15 more
doaj   +1 more source

Effect of a high‐fat and high‐calorie food on the pharmacokinetics of a novel, potent GABA analog HSK16149 in healthy subjects

Pharmacology Research & Perspectives, 2023
HSK16149 is a novel, potent gamma‐aminobutyric acid (GABA) analog for the treatment of neuropathic pain. The purpose of this study was to assess the effect of a high‐fat and high‐calorie meal on the pharmacokinetics of HSK16149 in healthy Chinese ...
Qingqing Wu, Huijuan Zhu, Rong Song, Mengqi Zhang, Fangqiong Li, Weifang Zeng, Wei Wang, Jingying Jia, Chen Yu, Yanmei Liu   +9 more
doaj   +1 more source

Bioequivalence and food effect of a fixed‐dose combination of macitentan and tadalafil: Adaptive design in the COVID‐19 pandemic

Pharmacology Research & Perspectives, 2021
The COVID‐19 pandemic has forced clinical studies to accommodate imposed limitations. In this study, the bioequivalence part could not be conducted as planned.
Dénes Csonka, Vladislav Fishman, Jaya Natarajan, Hans Stieltjes, Danielle Armas, Victor Dishy, Juan Jose Perez Ruixo   +6 more
doaj   +1 more source

Stability of Flavan-3-ols, Theaflavins, and Methylxanthines in 30 Industrial Green, Black, and White Tea (Camellia sinensis L.) Extracts Characterized via Liquid Chromatography Techniques

Antioxidants, 2023
Commercially available tea extracts for dietary supplements and nutraceuticals are standardized to characteristic components of Camellia sinensis L., such as epigallocatechin gallate (EGCG) and total catechins or polyphenols.
Antonio M. Inarejos-Garcia, Julia Heil, Sonia Guilera Bermell, Gertrud E. Morlock   +3 more
doaj   +1 more source

Prediction for optimal dosage of pazopanib under various clinical situations using physiologically based pharmacokinetic modeling

Frontiers in Pharmacology, 2022
This study aimed to apply a physiologically based pharmacokinetic (PBPK) model to predict optimal dosing regimens of pazopanib (PAZ) for safe and effective administration when co-administered with CYP3A4 inhibitors, acid-reducing agents, food, and ...
Chunnuan Wu, Chunnuan Wu, Chunnuan Wu, Bole Li, Bole Li, Bole Li, Shuai Meng, Shuai Meng, Shuai Meng, Linghui Qie, Linghui Qie, Linghui Qie, Jie Zhang, Jie Zhang, Jie Zhang, Guopeng Wang, Cong Cong Ren   +16 more
doaj   +1 more source

Leveraging Physiologically Based Modelling to Provide Insights on the Absorption of Paliperidone Extended-Release Formulation under Fed and Fasting Conditions

Pharmaceutics, 2023
Paliperidone was approved by the US FDA in 2006 as an extended-release (ER) tablet (Invega®) for the once-daily treatment of schizophrenia. This osmotic-controlled release oral delivery system (OROS) offers advantages, such as the prevention of plasma ...
Saima Subhani, Viera Lukacova, Chaejin Kim, Leyanis Rodriguez-Vera, Paula Muniz, Monica Rodriguez, Rodrigo Cristofoletti, Sandra Van Os, Elena Suarez, Stephan Schmidt, Valvanera Vozmediano   +10 more
doaj   +1 more source

Influence of Food on Paediatric Gastrointestinal Drug Absorption Following Oral Administration: A Review

Children, 2015
The objective of this paper was to review existing information regarding food effects on drug absorption within paediatric populations. Mechanisms that underpin food–drug interactions were examined to consider potential differences between adult and ...
Hannah K. Batchelor
doaj   +1 more source

Self-Nano-Emulsifying Drug-Delivery Systems: From the Development to the Current Applications and Challenges in Oral Drug Delivery

Pharmaceutics, 2020
Approximately one third of newly discovered drug molecules show insufficient water solubility and therefore low oral bio-availability. Self-nano-emulsifying drug-delivery systems (SNEDDSs) are one of the emerging strategies developed to tackle the issues
Aristote B. Buya, Ana Beloqui, Patrick B. Memvanga, Véronique Préat   +3 more
doaj   +1 more source

Climate change impact on China food security in 2050 [PDF]

, 2012
Climate change is now affecting global agriculture and food production worldwide. Nonetheless the direct link between climate change and food security at the national scale is poorly understood.
Chen, Zhongxin, Fu, Yijiang, Li, Zhengguo, Tang, Huajun, Van Ranst, Eric, Wu, Wenbin, Xiong, Wei, Yang, Guixia, Yang, Peng, Ye, Liming, zou, Jinqiu   +10 more
core   +4 more sources

A Non-Nutritive Feeding Intervention Alters the Expression of Efflux Transporters in the Gastrointestinal Tract

Pharmaceutics, 2021
Intestinal interactions with nutrients, xenobiotics and endogenous hormones can influence the expression of clinically relevant membrane transporters.
Yang Mai, Francesca K. H. Gavins, Liu Dou, Jing Liu, Farhan Taherali, Manal E. Alkahtani, Sudaxshina Murdan, Abdul W. Basit, Mine Orlu   +8 more
doaj   +1 more source