Results 21 to 30 of about 31,268,655 (339)

High-fat diets enhance and delay ursodeoxycholic acid absorption but elevate circulating hydrophobic bile salts

Frontiers in Pharmacology, 2023
Background: Ursodeoxycholic acid (UDCA) is a natural drug essential for the treatment of cholestatic liver diseases. The food effects on the absorption of UDCA and the disposition of circulating bile salts remain unclear despite its widespread global ...
Liang Huang, Liang Huang, Wei Wei, Xiaomei Huang, Xuejing Li, Haisha Liu, Lanlan Gui, Lanlan Gui, Jinping Jiang, Linfei Wan, Xiangxiang Zhou, Jingsong Ding, Xuehua Jiang, Bikui Zhang, Ke Lan, Ke Lan   +15 more
doaj   +1 more source

Food Security Simulator – Nigeria

, 2023
The Food Security Simulator is an innovative and easy-to-use, MS-Excel-based tool for assessing the potential short-term impacts of food price or household income shocks on food security and people’s diets.
International Food Policy Research Institute (IFPRI)
core   +1 more source

Bioequivalence and pharmacodynamics of a generic dabigatran etexilate capsule in healthy Chinese subjects under fasting and fed conditions

Pharmacology Research & Perspectives, 2020
To assess bioequivalence of a generic dabigatran etexilate capsule in healthy Chinese subjects under fasting and fed conditions. This was an open‐label, single‐center, randomized four‐period crossover study with a 7‐day washout period. A single oral dose
Xin Li, Lihua Liu, Bing Xu, Qian Xiang, Yuan Li, Ping Zhang, Yangyang Wang, Qiufen Xie, Yong Mao, Yimin Cui   +9 more
doaj   +1 more source

Bioavailability Enhancement and Food Effect Elimination of Abiraterone Acetate by Encapsulation in Surfactant-Enriched Oil Marbles

AAPS Journal, 2020
Abiraterone acetate has limited bioavailability in the fasted state and exhibits a strong positive food effect. We present a novel formulation concept based on the so-called oil marbles (OMs) and show by in vitro and in vivo experiments that the food ...
Tereza Boleslavská, Ondřej Rychecký, Martin Krov, P. Žvátora, O. Dammer, J. Beránek, Petr Kozlík, T. Křížek, J. Hořínková, P. Ryšánek, Jaroslava Roušarová, N. Canová, M. Šíma, O. Slanař, F. Štěpánek   +14 more
semanticscholar   +1 more source

Effect of food on absorption of lomefloxacin [PDF]

Antimicrobial Agents and Chemotherapy, 1990
Twelve subjects participated in an open-label, single-dose, balanced three-way crossover study in which the absorptions of lomefloxacin were compared following (i) an overnight fast, (ii) a carbohydrate meal, and (iii) a high-fat meal. The time to peak concentration of lomefloxacin was delayed, but peak concentration in plasma and amount of drug ...
Hooper W.D., Dickinson R.G., Eadie M.J.
openaire   +4 more sources

Food Effect Projections via Physiologically Based Pharmacokinetic Modeling: Predictive Case Studies.

Journal of Pharmacy and Science, 2019
Food can alter the absorption of orally administered drugs. Biopharmaceutics physiologically based pharmacokinetic (PBPK) modeling offers the possibility to simulate a compound's pharmacokinetics under fasted or fed states. To advance the utility of PBPK
C. Tistaert, T. Heimbach, Binfeng Xia, N. Parrott, T. Samant, F. Kesisoglou   +5 more
semanticscholar   +1 more source

Effect of Food on Propranolol Oral Clearance and a Possible Mechanism of This Food Effect.

Biological and Pharmaceutical Bulletin, 1994
To better define the mechanism of the increased plasma concentration of propranolol (PL) after meals, the effect of the dietary constitution of a meal on the kinetics of PL and beta-naphthoxylactic acid (NLA), a main metabolite, after administration of the drug, was investigated in rats.
OGISO, Taro, IWAKI, Masahiro, TANINO, Tadatoshi, KAWAFUCHI, Ritsuko, HATA, Sumiko   +4 more
openaire   +3 more sources

The Effect of Food Involvement and Food Addiction on Food Neophobia

Annals of Health and Health Sciences, 2016
Food neophobia can be defined as the reluctance of the consumers to try novel foods, including food products, dishes and cuisines. In the present study, it was suggested that the food neophobia is positively related with food addiction and negatively with the food involvement.
Rachita Kashyap, P. Abhilash
openaire   +1 more source

Open-Label, Phase I, Pharmacokinetic Studies in Healthy Chinese Subjects to Evaluate the Bioequivalence and Food Effect of a Novel Formulation of Abiraterone Acetate Tablets

Drug Design, Development and Therapy, 2022
Zeying Feng,1,2,* Yaxin Liu,1,2,* Yun Kuang,2 Shuang Yang,2 Jinlei Li,2 Ling Ye,2 Jie Huang,2 Qi Pei,3 Yuanyuan Huang,1,4 Guoping Yang1– 3 1XiangYa School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, 410013, People’s ...
Feng Z, Liu Y, Kuang Y, Yang S, Li J, Ye L, Huang J, Pei Q, Huang Y, Yang G   +9 more
doaj  

A New Plant Active Polysaccharide from Nicotiana Improves the Lead-Led Impairment of Spatial Memory in Mice by Modulating the Gut Microbiota and IL-6

Foods
Active polysaccharides from plants are broadly applied in the food and health industry. The purpose of this study is to identify a new plant active polysaccharide and to investigate its role in modulating spatial memory.
Ruili Yang, Feng Zhu, Wanying Mo, Huailong Li, Dongliang Zhu, Zengyang He, Xiaojing Ma   +6 more
doaj   +1 more source