Results 21 to 30 of about 1,592,305 (263)

Pharmacokinetics and Bioequivalence of Rasagiline Tablets in Chinese Healthy Subjects Under Fasting and Fed Conditions: An Open, Randomized, Single-Dose, Double-Cycle, Two-Sequence, Crossover Trial

Frontiers in Pharmacology, 2020
Objective: This study evaluated the pharmacokinetics, safety, and bioequivalence (BE) of two formulations of rasagiline tablets in healthy Chinese subjects under fasting and fed conditions.Methods: An open, randomized, single-dose, double-cycle, two ...
Yinjuan Li, Lu Qi, Haihong Bai, Ying Liu, Rongxia Fan, Yongrui Tu, Yongqiang Sun, Juxiang Wang, Qi Qi, Xiaohui Feng, Da Zhou, Xinghe Wang   +11 more
doaj   +1 more source

A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosphodiesterase Type 5 Inhibitor, in Healthy Subjects

Drug Design, Development and Therapy, 2021
Hongjie Qian,1,2 Qian Chen,1,2 Liyu Liang,1,2 Yang Zou,1,2 Huahua Pu,1,2 Liang Xin,1,2 Rong Song,1,2 Tingting Li,1,2 Huijuan Zhu,1,2 Yu Wang,3 Guanghui Tian,4 Jingshan Shen,2,3 Hualiang Jiang,2,3 Chen Yu,1,2 Zhen Wang,2,3 Jingying Jia1,2 1Central ...
Qian H, Chen Q, Liang L, Zou Y, Pu H, Xin L, Song R, Li T, Zhu H, Wang Y, Tian G, Shen J, Jiang H, Yu C, Wang Z, Jia J   +15 more
doaj  

Effect of Food on Propranolol Oral Clearance and a Possible Mechanism of This Food Effect.

Biological and Pharmaceutical Bulletin, 1994
To better define the mechanism of the increased plasma concentration of propranolol (PL) after meals, the effect of the dietary constitution of a meal on the kinetics of PL and beta-naphthoxylactic acid (NLA), a main metabolite, after administration of the drug, was investigated in rats.
OGISO, Taro, IWAKI, Masahiro, TANINO, Tadatoshi, KAWAFUCHI, Ritsuko, HATA, Sumiko   +4 more
openaire   +3 more sources

Stability of Flavan-3-ols, Theaflavins, and Methylxanthines in 30 Industrial Green, Black, and White Tea (Camellia sinensis L.) Extracts Characterized via Liquid Chromatography Techniques

Antioxidants, 2023
Commercially available tea extracts for dietary supplements and nutraceuticals are standardized to characteristic components of Camellia sinensis L., such as epigallocatechin gallate (EGCG) and total catechins or polyphenols.
Antonio M. Inarejos-Garcia, Julia Heil, Sonia Guilera Bermell, Gertrud E. Morlock   +3 more
doaj   +1 more source

Nymph and Adult Performance of the Small Green Stink Bug, Piezodorus guildinii (Westwood) on Lanceleaf Crotalaria and Soybean

Brazilian Archives of Biology and Technology, 2002
Lanceleaf crotalaria, Crotalaria lanceolata E. Mey (Leguminosae) was found hosting the small green stink bug, Piezodorus guildinii (Westwood), in Paraná State, Brazil.
Antônio Ricardo Panizzi, Shirlei Regina Cardoso, Viviane Ribeiro Chocorosqui   +2 more
doaj   +1 more source

The Effect of Food Involvement and Food Addiction on Food Neophobia

Annals of Health and Health Sciences, 2016
Food neophobia can be defined as the reluctance of the consumers to try novel foods, including food products, dishes and cuisines. In the present study, it was suggested that the food neophobia is positively related with food addiction and negatively with the food involvement.
Rachita Kashyap, P. Abhilash
openaire   +1 more source

Integration of a Physiologically Based Pharmacokinetic and Pharmacodynamic Model for Tegoprazan and Its Metabolite: Application for Predicting Food Effect and Intragastric pH Alterations

Pharmaceutics, 2022
A physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) model for tegoprazan and its major metabolite M1 was developed to predict PK and PD profiles under various scenarios. The PBPK model for tegoprazan and M1 was developed and predicted using
Hyeon-Cheol Jeong, Min-Gul Kim, Zhuodu Wei, Kyeong-Ryoon Lee, Jaehyeok Lee, Im-Sook Song, Kwang-Hee Shin   +6 more
doaj   +1 more source

A New Plant Active Polysaccharide from Nicotiana Improves the Lead-Led Impairment of Spatial Memory in Mice by Modulating the Gut Microbiota and IL-6

Foods
Active polysaccharides from plants are broadly applied in the food and health industry. The purpose of this study is to identify a new plant active polysaccharide and to investigate its role in modulating spatial memory.
Ruili Yang, Feng Zhu, Wanying Mo, Huailong Li, Dongliang Zhu, Zengyang He, Xiaojing Ma   +6 more
doaj   +1 more source

Synthesis and Physicochemical Evaluation of Entecavir-Fatty Acid Conjugates in Reducing Food Effect on Intestinal Absorption

Molecules, 2018
The oral bioavailability of entecavir (EV), an anti-viral agent commonly prescribed to treat hepatitis B infections, is drastically reduced under a post-prandial state. This is primarily due to its low permeability in the gastrointestinal tract.
Hyuck Jun Jung, Myoung Jin Ho, Sungwan Ahn, Young Taek Han, Myung Joo Kang   +4 more
doaj   +1 more source

On Absorption Modeling and Food Effect Prediction of Rivaroxaban, a BCS II Drug Orally Administered as an Immediate-Release Tablet

Pharmaceutics, 2021
The present work evaluates the food effect on the absorption of rivaroxaban (Riva), a BCS II drug, from the orally administered commercial immediate-release tablet (Xarelto IR) using physiologically based pharmacokinetic (PBPK) and conventional in vitro ...
Varun Kushwah, Sumit Arora, Miklós Tamás Katona, Dattatray Modhave, Eleonore Fröhlich, Amrit Paudel   +5 more
doaj   +1 more source