Results 281 to 290 of about 2,678,588 (368)

Safety and Efficacy of Damoctocog Alfa Pegol in Previously Treated Children Aged 7 to < 12 Years With Severe Haemophilia A in the Phase 3, Open Label Alfa‐PROTECT Main Study

European Journal of Haematology, EarlyView.
ABSTRACT Background In the earlier PROTECT VIII Kids study (NCT01775618), damoctocog alfa pegol was efficacious for prevention and treatment of bleeds in children aged < 12 years with severe haemophilia A. Objective Assess the safety of damoctocog alfa pegol, including hypersensitivity and loss of efficacy (LoE) due to an immune response to ...
Margareth C. Ozelo, Matteo Luciani, Heidi Glosli, Kaan Kavakli, Nasrin Samji, Gregory C. Makris, Claudia Tueckmantel, Monika Maas Enriquez, Luciana C. Oliveira, Shveta Gupta, Mario Guillermo Arbesú, Mauro Davoli, Anthony K. C. Chan, Maria E. Mancuso   +13 more
wiley   +1 more source

Aural plaques: Considerations on autohaemotherapy treatment in four Mangalarga Marchador crossbred horses

Equine Veterinary Education, EarlyView.
Summary The occurrence of Aural Plaques (AP) in horses, attributed to infection with Equus caballus Papillomavirus (EcPV), has become increasingly prevalent in equine breeding populations. Major challenges in managing this condition include genetic susceptibility to the virus, significant variability in individual immune responses among horses and the ...
E. Bastianetto, M. I. de Azevedo, I. S. Ferrão, P. Fantini, E. M. M. Lima, M. B. Castro, C. B. de Melo   +6 more
wiley   +1 more source

TbTim20 facilitates protein import at a low membrane potential in trypanosomes lacking the mitochondrial genome

The FEBS Journal, EarlyView.
Protein import into mitochondria relies on TIM complexes and the membrane potential. Trypanosoma brucei has a unique TIM complex, and the role of one subunit, TbTim20, has remained unclear. Here, we show that TbTim20 is essential in cells lacking mitochondrial DNA. The importance of TbTim20 increases as the membrane potential decreases.
Corinne von Känel, Salome Aeschlimann, Michaela Husová, Silke Oeljeklaus, Philip Stettler, Achim Schnaufer, Bettina Warscheid, Alena Zíková, André Schneider   +8 more
wiley   +1 more source

The Real Danger for Milk Protein Allergy: Developing a Scale for Family Doctors on Introducing Diet Diversity to Infants with Cow's Milk Protein Allergy. [PDF]

Nutrients
Stafie CS.
europepmc   +1 more source

Drug Allergy Risk Stratification in Children With Immediate or Delayed Urticaria During Antibiotic Treatment

Clinical &Experimental Allergy, EarlyView.
Francesca Mori, Leonardo Tomei, Chiara Marzi, Giulia Liccioli, Simona Barni, Mattia Giovannini, Lucrezia Sarti, Benedetta Pessina, Lene Heise Garvey   +8 more
wiley   +1 more source

Transcriptional regulation of human NMNAT2: insights from 3D genome sequencing and bioinformatics

The FEBS Journal, EarlyView.
NMNAT2 is a valuable drug target, as low levels increase the risk of neurodegeneration. We employed 4C‐seq to identify NMNAT2 regulatory regions in the human genome, revealing distinct interactomes of the NMNAT2 promoter in undifferentiated and neuron‐like SH‐SY5Y cells. Additionally, we uncovered NMNAT2‐associated genes and transcription factors. This
Yu Chen Chang, Sen Yang, Minyoung Cho, Kwangsik Nho, José‐Manuel Baizabal, Hui‐Chen Lu   +5 more
wiley   +1 more source

Clinical Outcomes and Food Triggers Following Low Food Chemical Diet Implementation: A Retrospective Audit of Dietetic Practice. [PDF]

J Hum Nutr Diet
Cooke Z, Lynam K, Barrett J, Biesiekierski JR, Trakman G, Tuck CJ.   +5 more
europepmc   +1 more source

The Influence of Pregnancy Risk Factors on Patterns of Sensory Processing Disorders and Motor Development. [PDF]

J Clin Med
Szczepara-Fabian M, Emich-Widera E, Kazek B, Paprocka J.   +3 more
europepmc   +1 more source

Ticked Off: Allergic Effector Cells in the Pathogenesis of Alpha-gal Syndrome. [PDF]

Curr Allergy Asthma Rep
Kepley CL, Wang Y, Yelton A, Siebert ER, Iweala OI.   +4 more
europepmc   +1 more source

Pathophysiological mechanisms of functional dyspepsia: a narrative review. [PDF]

Front Med (Lausanne)
Wang L, Shi Y, Li Y, Wang X, Xu L, Zhang Y.   +5 more
europepmc   +1 more source