Results 41 to 50 of about 59,162,053 (288)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Developing sous vide/freezing systems for ready-meal components [PDF]

, 2005
End of Project ReportSous vide cooking involves sealing raw or par-cooked food in a vacuumised laminated plastic pouch or container, cooking by controlled heating, rapid chilling and then re-heating for consumption. The chilled storage period is up to 21
O'Beirne, David, Gormley, Ronan T., Oliveira, Jorge, Tansey, Fergal, Carbonell, Serge, Bourke, Paula   +5 more
core   +1 more source

Up-Cycling of Olea europaea L. Ancient Cultivars Side Products: Study of a Combined Cosmetic–Food Supplement Treatment Based on Leaves and Olive Mill Wastewater Extracts

Life, 2023
In recent years, a reversal of the global economic framework has been taking place: from the linear model, there has been a gradual transition to a circular model where by-products from the agri-food industry are taken and transformed into value products
Raissa Buzzi, Irene Gugel, Stefania Costa, Sonia Molesini, Silvia Boreale, Erika Baldini, Nicola Marchetti, Silvia Vertuani, Patrizia Pinelli, Silvia Urciuoli, Anna Baldisserotto, Stefano Manfredini   +11 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Food industry by-products as raw materials in functional food production

Hrana u zdravlju i bolesti, 2014
Western civilization problems nowadays are overweight, obesity, diabetes, cardiovascular diseases, cancer and different disorders closely linked to unbalanced diet. Since it is extremely difficult to influence nutritional preferences of consumers, food industry is now increasingly developing new products, such as bread, pasta, snack products and other ...
Jozinović, Antun, Šubarić, Drago, Ačkar, Đurđica, Miličević, Borislav, Babić, Jurislav   +4 more
openaire   +5 more sources

Modifying Wheat Bran Dietary Fiber Using High-temperature Steaming with Ultrasound-assisted Compound Enzymatic Method: Process Optimization and Effects on in Vitro Probiotic Activity

Shipin gongye ke-ji
Defatted wheat bran was modified via high-temperature steaming combined with ultrasound-assisted enzymatic treatments. We investigated the influence of various factors on the yield of soluble dietary fiber (SDF). The physicochemical properties of dietary
Meng WANG, Quan LIU, Xiqun ZHENG, Caixia JIANG, Juntong WANG, Hao HU, Zhi ZHANG   +6 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Sustainable consumption : the role of food retail [PDF]

, 2012
This submission is informed by discussion at a seminar held by the Sustainable Consumption Roundtable on 28 June on the subject of Sustainable Consumption in the 'Food industry sustainability strategy'.
Sustainable Consumption Roundtable (Great Britain)
core   +2 more sources

Defatted hickory meal hydrolysate’s impact on memory impairment induced by D-galactose in mice

Food Science and Human Wellness
Defatted hickory meal (DHM), a by-product of hickory oil production, is a protein source rich in essential amino acids. In this study, the functional properties of DHM hydrolysate (DHMH) were assessed using in vitro and in vivo assays in context to its ...
Fanping Qin, Ruiling Liu, Qi Kong, Hangjun Chen, Xiangjun Fang, Huizhi Chen, Weijie Wu, Haiyan Gao   +7 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source