Results 91 to 100 of about 2,058,396 (312)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Scientific Opinion on Flavouring Group Evaluation 300 (FGE.300): One cyclo‐aliphatic amide from chemical group 33

open access: yesEFSA Journal, 2011
The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate a flavouring substance in the Flavouring Group Evaluation 300 using the Procedure in Commission Regulation (EC ...
EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF)
doaj   +1 more source

Analysis of the Economic Effects of Requiring Post-harvest Processing for Raw Oysters [PDF]

open access: yes
oysters, post-harvest processing, hydrostatic pressure, cool pasteurization, GIS, Agricultural and Food Policy, Food Consumption/Nutrition/Food Safety, L510, Q180, Q220,
Karns, Shawn A.   +2 more
core   +1 more source

Processing strategies. QLIF subproject 5: Development of a framework for the design of minimum and low input processing strategies, that guarantee food quality and safety [PDF]

open access: yes, 2009
Organic processing standards already prohibit the use of many chemicals, additives and preservatives, which are used in the processing of conventional foods.
Kretzschmar, U.
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Metabolomics analysis reveals the bitter active ingredients in Lonicera caerulea L.

open access: yesFrontiers in Nutrition
IntroductionBlue honeysuckle (Lonicera caerulea L.) is a nutritionally valuable cold-climate berry characterized by a considerable bitter taste. While bitter compounds in plant foods are often associated with favorable physiological activities, their ...
Ling Zhu   +17 more
doaj   +1 more source

Scientific Opinion on the safety evaluation of the substance, 1,2‐benzisothiazol‐3(2H)‐one 1,1‐dioxide, sodium salt, CAS No. 128‐44‐9, for use in food contact materials

open access: yesEFSA Journal, 2012
This scientific opinion of EFSA deals with the risk assessment of the additive 1,2‐benzisothiazol‐3(2H)‐one 1,1‐dioxide, sodium salt (saccharin, sodium salt), with CAS No 128‐44‐9 and FCM Substance No 902, for use as a nucleating agent up to 0.1% w/w in ...
EFSA Panel on food contact materials, enzymes, flavourings and processing aids (CEF)
doaj   +1 more source

Conclusions [PDF]

open access: yes, 2005
One of the basic problems in local organic food systems seems to be connected to food chains. The range of creative initiatives covers all thinkable fields: information about ecology, farmers' own activities in creating brands and labels, associations ...
Kakriainen, Salla, von Essen, Hans
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Scientific Opinion on Flavouring Group Evaluation 06, Revision 3 (FGE.06Rev3): Straight‐ and branched‐chain aliphatic unsaturated primary alcohols, aldehydes, carboxylic acids, and esters from chemical groups 1 and 4

open access: yesEFSA Journal, 2011
The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 50 flavouring substances in the Flavouring Group Evaluation 6, Revision 3, using the Procedure in Commission ...
EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF)
doaj   +1 more source

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