Results 131 to 140 of about 4,030,393 (147)

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

Advanced Science, EarlyView.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong, Duo Liu, Songsen Fu, Jiaming Zhang, Xi Chen, Songqiang Huang   +5 more
wiley   +1 more source

Single‐Field Evolution Rule Governs the Dynamics of Representational Drift in Mouse Hippocampal Dorsal CA1 Region

Advanced Science, EarlyView.
Long‐term hippocampal place‐code dynamics are investigated using calcium imaging across weeks of maze navigation. Analyses reveal a novelty‐irrelevant Single‐Field Evolution Rule (SFER), where active fields promote persistence and inactive fields decline.
Cong Chen, Shuyang Yao, Sihui Cheng, Jiayi Tian, Ang Li, Yusen Yan, Xiang Zhang, Yuanjing Liu, Yumeng Wang, Qichen Cao, Chenglin Miao   +10 more
wiley   +1 more source

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

A Minimally Invasive Framework Reveals Region‐Specific Cerebrovascular Remodeling in Aging Using Intravital Functional Ultrasound Imaging and Ultrasound Localization Microscopy (fUS‐ULM)

Advanced Science, EarlyView.
A high‐resolution intravital imaging platform combining functional ultrasound and localization microscopy enables longitudinal, minimally invasive assessment of cerebrovascular function in aging studies. The present investigation reveals aging‐related reductions in neurovascular coupling, arteriole‐to‐venule ratio and vascular density, introducing a ...
Sharon Negri, Adam Nyul‐Toth, Madison Milan, Eva Troyano‐Rodriguez, Sherwin Tavakol, Jennifer Ihuoma, Zeke Reyff, Rakesh Rudraboina, Rafal Gulej, Raymond Jang, Anna Csiszar, Zoltan Ungvari, Audrey Cleuren, David R Miller, Andriy Yabluchanskiy, Mickael Tanter, Stefano Tarantini   +16 more
wiley   +1 more source

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Household food security in the United States in 2022

, 2023
Most U.S. households have consistent, dependable access to enough food for active, healthy living--they are food secure. However, some households experience food insecurity at times during the year, meaning their access to adequate food is limited by a ...
M. Rabbitt, Laura J. Hales, Michael P. Burke, Alisha Coleman-Jensen   +3 more
semanticscholar   +1 more source

The impact of disasters and crises on agriculture and food security: 2021

, 2021
On top of a decade of exacerbated disaster loss, exceptional global heat, retreating ice and rising sea levels, humanity and our food security face a range of new and unprecedented hazards, such as megafires, extreme weather events, desert locust swarms ...

semanticscholar   +1 more source

Food security and disruptions of the global food supply chains during COVID-19: building smarter food supply chains for post COVID-19 era

British Food Journal, 2022
PurposeThe COVID-19 pandemic has revealed the fragility of the complex global food supply chains (GFSCs) which has drastically affected the essential flow of food from the farms and producers to the final consumers.
Michael Omotayo Alabi, Ojelanki K. Ngwenyama   +1 more
semanticscholar   +1 more source

Reviewing the impact of climate change on global food security: Challenges and solutions

International journal of applied research in social sciences
This review examines the intricate relationship between climate change and global food security, elucidating the challenges posed by climate variability and exploring potential solutions to mitigate its adverse effects. Climate change presents formidable
Adekunle Stephen Toromade, Deborah Aanuoluwa Soyombo, Eseoghene Kupa, Tochukwu Ignatius Ijomah   +3 more
semanticscholar   +1 more source

Household food security in the United States in 2023

This report provides statistics on food security in U.S. households throughout 2023 based on the Current Population Survey Food Security Supplement data collected by the U.S. Department of Commerce, Bureau of the Census, in December 2023. An estimated 86.
M. Rabbitt, Madeline Reed-Jones, Laura J. Hales, Michael P. Burke   +3 more
semanticscholar   +1 more source

COVID-19 risks to global food security

Science, 2020
Economic fallout and food supply chain disruptions require attention from policy-makers As the COVID-19 pandemic progresses, trade-offs have emerged between the need to contain the virus and to avoid disastrous economic and food security crises that hurt
D. Laborde, W. Martin, J. Swinnen, R. Vos   +3 more
semanticscholar   +1 more source