Results 31 to 40 of about 1,693,854 (291)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The climate-smart village approach: framework of an integrative strategy for scaling up adaptation options in agriculture

Ecology and Society, 2018
Increasing weather risks threaten agricultural production systems and food security across the world. Maintaining agricultural growth while minimizing climate shocks is crucial to building a resilient food production system and meeting developmental ...
Pramod K. Aggarwal, Andy Jarvis, Bruce M. Campbell, Robert B. Zougmoré, Arun Khatri-Chhetri, Sonja J. Vermeulen, Ana Maria Loboguerrero, Leocadio S. Sebastian, James Kinyangi, Osana Bonilla-Findji, Maren Radeny, John Recha, Deissy Martinez-Baron, Julian Ramirez-Villegas, Sophia Huyer, Philip Thornton, Eva Wollenberg, James Hansen, Patricia Alvarez-Toro, Andrés Aguilar-Ariza, David Arango-Londoño, Victor Patiño-Bravo, Ovidio Rivera, Mathieu Ouedraogo, Bui Tan. Yen   +24 more
doaj   +1 more source

Circulating levels of acute-phase proteins, heat shock protein 70, and corticosterone in the serum of developing chick embryos and newly hatched broiler chicks

Italian Journal of Animal Science, 2021
Acute-phase proteins (APPs) are known to mediate the body's first line of defence against external insults in poultry and there is a growing interest to use the proteins to diagnose poultry health and physiological status.
Ahmad Hanafi Sulong, Idrus Zulkifli, Suriya Kumari Ramiah, Eric Lim Teik Chung, Elmutaz Atta Awad, Awis Qurni Sazili   +5 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Process evaluation of Project Daire: a food environment intervention that impacted food knowledge, wellbeing and dietary habits of primary school children

BMC Public Health
Background Project DAIRE was a randomised-controlled, factorial design trial which aimed to improve children’s health-related quality of life, wellbeing, food knowledge and dietary habits via two multi-component interventions: Nourish and Engage. Nourish
Naomi Anderson, Sarah F. Brennan, Fiona Lavelle, Sarah E. Moore, Dilara Olgacher, Amy Junkin, Moira Dean, Michelle C. McKinley, Patrick McCole, Ruth F. Hunter, Laura Dunne, Niamh E. O’Connell, Chris T. Elliott, Danielle McCarthy, Jayne V. Woodside   +14 more
doaj   +1 more source

Prevalence and Antibiogram Profiling of Extended-Spectrum Beta-Lactamase (ESBL) Producing Escherichia coli in Raw Vegetables, in Malaysia

Biology and Life Sciences Forum, 2021
The prevalence of antimicrobial resistance has drawn the public’s attention worldwide. The presence of ESBL E. coli in fresh produce and other food represents a growing problem involving food safety and has become a global food safety issue.
Epeng Lee, Son Radu, Nuzul Noorahya Jambari, Noor Azira Abdul-Mutalib   +3 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Quantifying the Respiratory Pattern of Sorghum Rhizosphere Microbial Communities Under Legume-Based Rotation via the MicroResp Method

Applied and Environmental Soil Science
The inclusion of legumes in crop rotation has been recognized for its potential to increase soil fertility and microbial functionality. We posited that microbial communities in legume-based rotation systems exhibit distinct community-level physiological ...
Ben Jesuorsemwen Enagbonma, David Mxolisi Modise, Olubukola Oluranti Babalola   +2 more
doaj   +1 more source

Effects of protease supplementation of low protein and/or energy diets on growth performance and blood parameters in broiler chickens under heat stress condition

Italian Journal of Animal Science, 2019
The effects of feeding low dietary crude protein (CP) and/or metabolisable energy (ME) with or without supplemental protease on growth performance, carcase characteristics and physiological responses in broiler chickens were investigated under cyclic ...
Fang Lin Law, Zulkifli Idrus, Abdoreza Soleimani Farjam, Liang Juan Boo, Elmutaz Atta Awad   +4 more
doaj   +1 more source