Results 51 to 60 of about 378,657 (302)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

(Im)permanent Settlement: Protracted Displacement and Secondary Movement Experiences of Syrian Refugees from Turkey to Austria

Social Sciences
In 2022, Austria experienced a significant surge in Syrian arrivals. Unlike refugees arriving to Europe in 2015/2016, who predominantly embarked on direct journeys from Syria, most of the recently admitted cohort experienced protracted displacement in ...
Judith Kohlenberger, Sophie Reichelt, Kotayba Kadri   +2 more
doaj   +1 more source

Forced displacement of Burmese people [PDF]

Forced Migration Review, 2008
This issue of FMR aims to help bring the crisis of forceddisplacement of Burmese people back into theinternational spotlight.
Inge Brees
doaj  

Resonant forcing of nonlinear systems of differential equations

, 2008
We study resonances of nonlinear systems of differential equations, including but not limited to the equations of motion of a particle moving in a potential.
Alfred W. Hübler, Hübler A. W., Vadas Gintautas   +2 more
core   +1 more source

The Institution of Gender-Based Asylum and Epistemic Injustice: A Structural Limit [PDF]

, 2018
One of the recent attempts to explore epistemic dimensions of forced displacement focuses on the institution of gender-based asylum and hopes to detect forms of epistemic injustice within assessments of gender related asylum applications.
Sertler, Ezgi
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Biofilms as potential reservoirs of antimicrobial resistance in vulnerable settings

Frontiers in Public Health
Antimicrobial resistance is a major global health threat, characterized by the ability of microorganisms to withstand the effects of antimicrobial agents. Biofilms, as unique microbial communities, significantly contribute to this threat.
Yanina Nahum, Yanina Nahum, Johnathan Muhvich, José Rubén Morones-Ramirez, José Rubén Morones-Ramirez, Nestor G. Casillas-Vega, Muhammad H. Zaman, Muhammad H. Zaman   +7 more
doaj   +1 more source

Transnationalization of human rights norms and its impact on internally displaced Kurds [PDF]

, 2005
This paper addresses the less researched topic of internal displacement as a human rights issue and analyzes the extent that the transnationalization of human rights issues and the pressures from regional organizations affected the rights of ethnic ...
Celik, Ayse Betul, Çelik, Ayşe Betül
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Effects of microplastic concentration, composition, and size on Escherichia coli biofilm-associated antimicrobial resistance

Applied and Environmental Microbiology
Microplastics (MPs) have emerged as a significant environmental pollutant with profound implications for public health, particularly as substrates to facilitate bacterial antimicrobial resistance (AMR).
Neila Gross, Johnathan Muhvich, Carly Ching, Bridget Gomez, Evan Horvath, Yanina Nahum, Muhammad H. Zaman   +6 more
doaj   +1 more source