Results 71 to 80 of about 948,710 (274)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Forced displacement and internal migration in Colombia, 1992-2004 [PDF]

This document deconstructs the issue of forced displacement in Colombia, focusing on the period 1992 – 2004, and has two main methodological features. The first is its interdisciplinary approach, which is both sociological and economic.
Guataquí Roa, Juan Carlos
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

CIVIL CONFLICT AND FORCED MIGRATION: THE MICRO DETERMINANTES AND THE WELFARE LOSSES OF DISPLACEMENT IN COLOMBIA [PDF]

During the last decade, forced internal displacement in Colombia has been a growing phenomenon closely linked to the escalation of the internal armed conflict - particularly in rural areas.
Ana Maria Ibáñez, Carlos Eduardo Vélez   +1 more
core  

Returnees’ Perspectives of the Adverse Impact of Forced Displacement on Children

Social Sciences
Conflict-related forced displacement, characterized by the experiences of witnessing violent acts, bombing, torture, separation, and the execution of family members, can severely and negatively impact a child’s social determinants of health (SDOH). These
Itunu O. Ilesanmi, Jasmine D. Haynes, Florence O. Ogundimu   +2 more
doaj   +1 more source

From Forced Migration to Displacement? [PDF]

Refugee Survey Quarterly
Abstract Should the multi-disciplinary field of Forced Migration Studies (FMS) re-orient itself around the concept of “displacement”? This short intervention situates this question against the background of the transition from Refugee Studies to FMS, as well as external developments in the realm of protection.
openaire   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The Unresolved History and Genealogy of Forced Displacement in Mexico

Íconos, 2016
This article reconstructs symbolic elements and practices that underline the recent dispute over the characterization and nature of “forced displacement” in Mexico.
Carolina Robledo Silvestre
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Iráčtí jezídé: Případová studie redefinice genderových rolí

Historická sociologie, 2019
The case study of Iraqi Yazidis and their changing gender roles and gender relations as a consequence of armed conflict and forced displacement is based on a field research conducted on the territory of northern Iraq in the Spring 2016.
Karel Černý
doaj   +1 more source