Results 61 to 70 of about 1,197,506 (281)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Techniques for approaching the dual Ramsey property in the projective hierarchy [PDF]

, 2001
We define the dualizations of objects and concepts which are essential for investigating the Ramsey property in the first levels of the projective hierarchy, prove a forcing equivalence theorem for dual Mathias forcing and dual Laver forcing, and show ...
Halbeisen, Lorenz, Loewe, Benedikt
core   +2 more sources

Forcing function control of Faraday wave instabilities in viscous shallow fluids

, 2005
We investigate the relationship between the linear surface wave instabilities of a shallow viscous fluid layer and the shape of the periodic, parametric-forcing function (describing the vertical acceleration of the fluid container) that excites them.
A. Messiah, Cristián Huepe, I. I. Goldman, L. D. Landau, Mary Silber, Paul Umbanhowar, Yu Ding   +6 more
core   +1 more source

Gap forcing

Israel Journal of Mathematics, 2001
16 pages. Submitted to the Journal of Mathematical Logic. The up-dated version includes an expanded introduction, which sets the main theorem in the historical context of the Levy-Solovay Theorem, and various other small ...
openaire   +3 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Ecological aspects of increasing intensity in pepper forcing with prime attention to the type of the growing equipment

Apstract: Applied Studies in Agribusiness and Commerce, 2017
Significant amount of profit can be generated in forcing technologies by the efficient use of different elements in growing technologies, however, improving production intensity is on the agenda in the sector.
Tibor Kicska
doaj   +1 more source

Slow Forcing in the Projective Dynamics Method

, 1998
We provide a proof that when there is no forcing the recently introduced projective dynamics Monte Carlo algorithm gives the exact lifetime of the metastable state, within statistical uncertainties.
Kolesik, M., Novotny, M. A., Rikvold, P. A.   +2 more
core   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Jensen ${\Delta }_n^1$ Reals by Means of ZFC and Second-Order Peano Arithmetic

Axioms
It was established by Jensen in 1970 that there is a generic extension L[a] of the constructible universe L by a non-constructible real a∉L, minimal over L, such that a is Δ31 in L[a].
Vladimir Kanovei, Vassily Lyubetsky
doaj   +1 more source