Results 71 to 80 of about 35,403 (305)

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Effect of random forcing on fluid lubricated bearing

, 2019
A model for a fluid lubricated bearing is derived for operation under conditions where external forces are subject to random fluctuations that may act to destabilise the bearing.
Power, H., Tretyakov, Michael V., Bailey, Nicola Y., Power, Henry, Bailey, N.Y., Bailey, Nicola Y. ; id_orcid, Tretyakov, M., Hibberd, Stephen, Hibberd, S.   +8 more
core   +1 more source

Patterns of change: whose fingerprint is seen in global warming? [PDF]

, 2011
Attributing observed climate change to causes is challenging. This letter communicates the physical arguments used in attribution, and the statistical methods applied to explore to what extent different possible causes can be used to explain the recent ...
Hegerl, Gabriele, Zwiers, Francis, Claudia Tebaldi, Francis Zwiers, Tebaldi, Claudia, Gabriele Hegerl   +5 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Anthropogenic influences on 2022-like summer heatwaves over the Yangtze River valley and projected changes in the likelihood of the event

Environmental Research Communications
During summer 2022, a record-breaking heatwave occurred in China over the Sichuan Basin to the middle and lower reaches of the Yangtze River valley. Observational analysis shows that this heatwave event peaks around 17th August, with an anomaly of 10 day
Mingming Zhang, Buwen Dong, Jon Robson, Reinhard Schiemann   +3 more
doaj   +1 more source

Secure Transmission in Cognitive Wiretap Networks with Full-Duplex Receivers

Applied Sciences, 2020
This paper studies the secure transmission in the dual-hop cognitive wiretap networks, where the secondary transmitter (Alice) aims to transmit confidential information to the secondary receiver (Bob) in the face of a multi-antenna relay (Relay), while ...
Zhihui Shang, Tao Zhang, Yueming Cai, Weiwei Yang, Hao Wu, Yu Zhang, Liwei Tao   +6 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Whole not hole : expert face recognition requires holistic perception

, 2010
Face recognition is an important ability of the human brain, yet its underlying mechanisms are still poorly understood. Two opposite views have been proposed to account for human face recognition expertise: the ability to extract the most diagnostic ...
Rossion, Bruno, Busigny, Thomas, Van Belle, Goedele, De Graef, Peter, Verfaillie, Karl   +4 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source