Results 81 to 90 of about 35,403 (305)

Regional scale impact of tidal forcing on groundwater flow in unconfined coastal aquifers

, 2014
This paper considers the impact of tidal forcing on regional groundwater flow in an unconfined coastal aquifer. Numerical models are used to quantify this impact for a wide range of hydrogeological conditions.
Oude Essink, Gualbert, Vandenbohede, Alexander, van der Zee, SEATM, E.A.T.M der der Zee, Sjoerd, Pauw, PS, Groen, J, Pauw, P.S., Vandenbohede, A., Oude Essink, GHP, Oude Essink, G.H.P., Leijnse, A, Landscape functioning, Geocomputation and Hydrology, Groen, J., Leijnse, A., Zee, S.E.A.T.M., van der, Hydrologie, van der Zee, S.E.A.T.M.   +16 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

The development of CC-TF-BiGRU model for enhancing accuracy in photovoltaic power forecasting

Scientific Reports
In the face of escalating global energy crises and pressing challenges of environmental pollution, the imperative for sustainable energy solutions has never been more pronounced.
Guomin Xie, Zijian Zhang, Zhongbao Lin, Sen Xie   +3 more
doaj   +1 more source

Post-Covid-19 business strategies in SMES in the municipality of Guasave, Sinaloa, Mexico

Ra Ximhai
The Covid-19 pandemic has had consequences for small and medium-sized enterprises (SMEs) around the world, forcing them to change the traditional way of operating.
Marcos Octavio Osuna Armenta, Mara del Rosario López Rodríguez, Xóchitl Patricia Flores Gutiérrez   +2 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

The Information-Forcing Dilemma in Damages Law

, 2016
Courts assessing compensatory damages awards often lack adequate information to determine the value of a victim’s loss. A central reason for this problem, which the literature has thus far overlooked, is that courts face a dilemma when applying their ...
Tun-Jen Chiang, Chiang, Tun-Jen
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Face mask detection

, 2023
The sudden outbreak of the Covid-19 pandemic globally has disrupted the daily lives of millions of people, forcing them to adapt to the “new normal”, which includes mandatory wearing of facemasks and face shields in public areas.
Chua, Delise Yun Jie
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Low‐Altitude High‐Latitude Stratospheric Aerosol Injection Is Feasible With Existing Aircraft

Earth's Future
Stratospheric aerosol injection (SAI) is a proposed method of climate intervention in which aerosols or their precursors would be injected into the stratosphere to reduce or halt global warming.
Alistair Duffey, Matthew Henry, Wake Smith, Michel Tsamados, Peter J. Irvine   +4 more
doaj   +1 more source