Results 201 to 210 of about 114,734 (298)

Neural Circuit Mechanisms of Disorders of Consciousness and Potential Therapeutic Targets of Brain Stimulation

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
This review integrates three hierarchical frameworks—ascending reticular activating system (ARAS), mesocircuit hypothesis, and intrinsic connectivity networks (ICNs)—to update the neural mechanisms of disorders of consciousness (DoC). We highlight emerging evidence for glutamatergic ARAS pathways, a bidirectional GPi–GPe mesocircuit regulating ...
Yichen Zhou, Tianqing Cao, Sipeng Zhu, Qiheng He, Yitong Jia, Xiaoke Chai, Nan Wang, Yi Yang   +7 more
wiley   +1 more source

β-catenin deficiency in forebrain excitatory neurons induces fear memory deficits and physiological alterations. [PDF]

Brain Commun
Hernandez Carballo LG, Senek R, Novototskaya-Vlasova K, Li P, Pletnikov M, Yan Z.   +5 more
europepmc   +1 more source

Whole‐Brain Monosynaptic Inputs and Outputs of Corticotropin‐Releasing Hormone Neurons of the Paraventricular Nucleus of the Hypothalamus in Male Mice

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Using rabies‐based monosynaptic retrograde tracing and AAV anterograde labeling, this study maps the brain‐wide inputs and outputs of PVN CRH neurons, identifying them as a key hub coordinating stress, autonomic, and behavioral responses. ABSTRACT Objective The paraventricular nucleus of the hypothalamus (PVN) is a central hub integrating ...
Ziteng Yue, Danyang Zhao, Xinxin Chen, Yousheng Zhang, Heng Zhang, Yinchang Wang, Yuhang Liu, Yuxin Yang, Can Geng, Yimeng Song, Xiaoyi Wang, Sheng Wang   +11 more
wiley   +1 more source

Lineage-Driven Understanding of Human Pericyte Heterogeneity in Vascular Modeling and Regeneration. [PDF]

Int J Stem Cells
Lee S, Baek CM, Lee S, Jo MG, Kim YJ.
europepmc   +1 more source

Basal Forebrain [PDF]

, 2011
openaire   +1 more source

An Open‐Label Study Investigating the 5‐HT2A Receptor Occupancy of Remlifanserin (ACP‐204) With the PET Radioligand [18F]Altanserin in Healthy Male Participants

Clinical Pharmacology in Drug Development, Volume 15, Issue 9, September 2026.
Abstract Remlifanserin (ACP‐204) is a selective 5‐HT2A receptor inverse agonist that builds upon scientific findings of its structural analog, pimavanserin. This Phase 1, open‐label study in healthy adults (N = 16) describes the central 5‐HT2A receptor occupancy of remlifanserin at different doses and plasma concentrations using positron emission ...
Ethan S. Burstein, Christine Sandiego, Brian Raether, Xiaoshu Feng, Bryan Dirks, Mona Darwish, Peter Zhang, David S. Russell, Eugenii A. Rabiner, Sanjeev Pathak   +9 more
wiley   +1 more source

Regulation of Neuronal Senescence by <i>Srebf2</i> and <i>Zmiz1</i> Reveals Mechanisms of Aging-Related Neurodegeneration. [PDF]

Biology (Basel)
Deng Z, Chen J, Li J, Luo X, Luo Q, Ren M, Li X.   +6 more
europepmc   +1 more source

Integrative analysis of single‐cell multi‐omics reveals heterogeneity in piriform cortex principal neurons and their selective vulnerability in Alzheimer's disease

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Integrative single‐cell multi‐omics analysis reveals molecular heterogeneity among piriform cortex principal neurons and identifies Reln+ superficial‐layer neurons as a selectively vulnerable population in Alzheimer's disease. Cross‐region comparison with entorhinal cortex layer II neurons reveals a shared Gpc5‐high/Sort1‐low vulnerability‐associated ...
Jiayue Meng, Miaomiao Zhang, Yujie Chen, Mengyao Han, Nianhao Cheng, Ruifang Cao, Qinwen He, Yaya Zhao, Liyun Yuan, Guoqing Zhang   +9 more
wiley   +1 more source

Before hormones: early sex-specific mechanisms shaping nervous system development, function, and postnatal disease susceptibility. [PDF]

Front Behav Neurosci
Tsiarli MA, Larschan EN.
europepmc   +1 more source

The Role of Hippocampal Interneuron Migration in Neurodevelopmental Disorders: A Systematic Review

Hippocampus, Volume 36, Issue 5, September 2026.
ABSTRACT Hippocampal abnormalities are frequently associated with neurodevelopmental disorders as interneurons are crucial in establishing the network connectivity of neurons. This systematic review analyzed primary literature with a focus on aberrant hippocampal interneuron migration as an etiology for neurodevelopmental disorders, summarizing the ...
M. A. C. Till, H. M. O. Reid, I. Murphy, B. R. Christie   +3 more
wiley   +1 more source