Brain Organization and Human Diseases
Cells, 2022 The cortex is a highly organized structure that develops from the caudal regions of the segmented neural tube. Its spatial organization sets the stage for future functional arealization.
Tamar Sapir +3 more
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Large-scale network organization in the avian forebrain: a connectivity matrix and theoretical analysis [PDF]
, 2013 Many species of birds, including pigeons, possess demonstrable cognitive capacities, and some are capable of cognitive feats matching those of apes.
Bingman, VP +4 more
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The Huntington's disease mutation impairs Huntingtin's role in the transport of NF-κB from the synapse to the nucleus [PDF]
, 2010 Expansion of a polyglutamine (polyQ) tract in the Huntingtin (Htt) protein causes Huntington's disease (HD), a fatal inherited neurodegenerative disorder.
Baquet +74 more
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Basal forebrain subcortical projections [PDF]
Brain Structure and Function, 2019 The basal forebrain (BF) contains at least three distinct populations of neurons (cholinergic, glutamatergic, and GABA-ergic) across its different regions (medial septum, diagonal band, magnocellular preoptic area, and substantia innominata). Much attention has focused on the BF's ascending projections to cortex, but less is known about descending ...
Lindsay J, Agostinelli +2 more
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Developmental Signatures of Microbiota-Derived Metabolites in the Mouse Brain
Metabolites, 2020 The gut microbiome is recognized to exert a wide-ranging influence on host health and disease, including brain development and behavior. Commensal bacteria can produce bioactive molecules that enter the circulation and impact host physiology and ...
Jonathan R. Swann +2 more
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Distribution of choline acetyltransferase (ChAT) immunoreactivity in the brain of the teleost cyprinus carpio [PDF]
, 2018 Cholinergic systems play a role in basic cerebral functions and its dysfunction is associated with deficit in neurodegenerative disease. Mechanisms involved in human brain diseases, are often approached by using fish models, especially cyprinids, given ...
Casini, Arianna +3 more
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An Evolutionary Interpretation of Teleostean Forebrain Anatomy [PDF]
, 2009 During the past few years, our investigations of the forebrain in the zebrafish (a teleost fish) have shown that its molecular anatomy and expression patterns of genes involved in the regulation of neuronal transmitter phenotypes, such as gamma ...
Mueller, Thomas, Wullimann, Mario F.
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The Lamprey Forebrain – Evolutionary Implications [PDF]
Brain, Behavior and Evolution, 2021 The forebrain plays a critical role in a broad range of neural processes encompassing sensory integration and initiation/selection of behaviour. The forebrain functions through an interaction between different cortical areas, the thalamus, the basal ganglia with the dopamine system, and the habenulae.
Shreyas M. Suryanarayana +3 more
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Minocycline Treatment Reverses Sound Evoked EEG Abnormalities in a Mouse Model of Fragile X Syndrome
Frontiers in Neuroscience, 2020 Fragile X Syndrome (FXS) is a leading known genetic cause of intellectual disability. Many symptoms of FXS overlap with those in autism including repetitive behaviors, language delays, anxiety, social impairments and sensory processing deficits ...
Jonathan W. Lovelace +6 more
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Genetic regulation of pituitary gland development in human and mouse [PDF]
, 2009 Normal hypothalamopituitary development is closely related to that of the forebrain and is dependent upon a complex genetic cascade of transcription factors and signaling molecules that may be either intrinsic or extrinsic to the developing Rathke’s ...
Aarskog +321 more
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