Cells, 2020 Human and murine studies identified the lysosomal enzyme acid sphingomyelinase (ASM) as a target for antidepressant therapy and revealed its role in the pathophysiology of major depression. In this study, we generated a mouse model with overexpression of
Iulia Zoicas +7 more
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Single-cell RNA sequencing identifies distinct mouse medial ganglionic eminence cell types. [PDF]
, 2017 Many subtypes of cortical interneurons (CINs) are found in adult mouse cortices, but the mechanism generating their diversity remains elusive. We performed single-cell RNA sequencing on the mouse embryonic medial ganglionic eminence (MGE), the major ...
Chen, Ying-Jiun J +7 more
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Pathogenetical significance of porencephalic lesions associated with intracerebral inoculation of sheep with the bovine spongiform encephalopathy (BSE) agent [PDF]
, 2009 Decreased rates of transmission of transmissible spongiform encephalopathies (TSEs) to sheep have been attributed to some polymorphisms of the prion protein (PrP) and to a ‘species barrier’ on interspecies experiments.
Card +21 more
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Dynamic RNA Regulation in the Brain Underlies Physiological Plasticity in a Hibernating Mammal
Frontiers in Physiology, 2021 Hibernation is a physiological and behavioral phenotype that minimizes energy expenditure. Hibernators cycle between profound depression and rapid hyperactivation of multiple physiological processes, challenging our concept of mammalian homeostasis.
Rui Fu +10 more
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Forebrain Origins of Glutamatergic Innervation to the Rat Paraventricular Nucleus of the Hypothalamus: Differential Inputs to the Anterior Versus Posterior Subregions [PDF]
, 2011 The hypothalamic paraventricular nucleus (PVN) regulates numerous homeostatic systems and functions largely under the influence of forebrain inputs. Glutamate is a major neurotransmitter in forebrain, and glutamate neurosignaling in the PVN is known to ...
Cullinan, William E +4 more
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A New Paradigm to Indicate Antidepressant Treatments
Pharmaceuticals, 2021 This article develops the idea that clinical depression can be seen as a typical human response, largely rooted in human culture, to events of loss or times of adversity. Various biological, psychological, and social factors may cause some individuals to
Anton J. M. Loonen +8 more
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Vascular Regulation of Developmental Neurogenesis
Frontiers in Cell and Developmental Biology, 2022 Evolutionary studies indicate that the nervous system evolved prior to the vascular system, but the increasing complexity of organisms prompted the vascular system to emerge in order to meet the growing demand for oxygen and nutrient supply.
Johanna Vogenstahl +7 more
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Forebrain control of breathing: Anatomy and potential functions
Frontiers in Neurology, 2022 The forebrain plays important roles in many critical functions, including the control of breathing. We propose that the forebrain is important for ensuring that breathing matches current and anticipated behavioral, emotional, and physiological needs ...
Karl M. Schottelkotte +3 more
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Interactions between the neuromodulatory systems and the amygdala: exploratory survey using the Allen Mouse Brain Atlas. [PDF]
, 2013 Neuromodulatory systems originate in nuclei localized in the subcortical region of the brain and control fundamental behaviors by interacting with many areas of the central nervous system.
Krichmar, Jeffrey L, Zaldivar, Andrew
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Endocrine Regulations, 2019 Objective. Prolonged treatment with neuroleptics has been shown to induce FosB/ΔFosB expression in several brain regions including the medial prefrontal cortex, dorsomedial and dorsolateral striatum, ventrolateral and dorsolateral septum, nucleus ...
Osacka Jana +3 more
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