Results 51 to 60 of about 114,734 (298)

Pax6 interactions with chromatin and identification of its novel direct target genes in lens and forebrain. [PDF]

, 2013
Pax6 encodes a specific DNA-binding transcription factor that regulates the development of multiple organs, including the eye, brain and pancreas. Previous studies have shown that Pax6 regulates the entire process of ocular lens development.
Tessa Walcher, Jovica Ninkovic (104237), David C Beebe, Deyou Zheng (7943), Ying Yang (24175), Xie, Q., Jie Huang, Louise Wolf (104240), Ariel Vitenzon (104242), Vitenzon, Ariel, Magdalena Götz, Zavadil, J., Wolf, L., Deyou Zheng, Götz, M., Yang, Ying, Ales Cvekl, Wolf, Louise, Tessa Walcher (104238), Yang, Y., Cvekl, A., Zheng, D.Y., Louise Wolf, Ninkovic, J., Jovica Ninkovic, Ariel Vitenzon, Götz, Magdalena, Jiri Zavadil (10270), Walcher, Tessa, Magdalena Götz (32199), Zavadil, Jiri, Qing Xie, Ninkovic, Jovica, Walcher, T., David C. Beebe (104247), Beebe, D.C., Zheng, Deyou, Huang, Jie, Cvekl, Ales, David C. Beebe, Xie, Qing, Jie Huang (104235), Ales Cvekl (104250), Vitenzon, A., Beebe, David C., Qing Xie (104232), Ying Yang, Jiri Zavadil, Huang, J.   +48 more
core   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Prospective identification of functionally distinct stem cells and neurosphere-initiating cells in adult mouse forebrain

eLife, 2014
Neurosphere formation is commonly used as a surrogate for neural stem cell (NSC) function but the relationship between neurosphere-initiating cells (NICs) and NSCs remains unclear.
John K Mich, Robert AJ Signer, Daisuke Nakada, André Pineda, Rebecca J Burgess, Tou Yia Vue, Jane E Johnson, Sean J Morrison   +7 more
doaj   +1 more source

Morphometric Analysis of the Corpus Callosum According to Age and Sex in Middle Eastern Arabs: Racial Comparisons and Clinical Correlations to Autism Spectrum Disorder

Frontiers in Systems Neuroscience, 2020
This study sought to examine the influence of age and sex on morphometric measurements of the corpus callosum (CC) within Middle Eastern Arab population, in order to obtain reference data and conduct racial comparisons with previously reported ...
Mohammed Z. Allouh, Mohammed Z. Allouh, Mohammed M. Al Barbarawi, Heba A. Ali, Ayman G. Mustafa, Safwan O. Alomari, Safwan O. Alomari   +6 more
doaj   +1 more source

Human cytomegalovirus induces significant structural and functional changes in terminally differentiated human cortical neurons

mBio, 2023
Human cytomegalovirus (HCMV) is a highly prevalent viral pathogen that typically presents asymptomatically in healthy individuals despite lifelong latency.
Jacob W. Adelman, Suzette Rosas-Rogers, Megan L. Schumacher, Rebekah L. Mokry, Scott S. Terhune, Allison D. Ebert   +5 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

T-Cell Factors as Transcriptional Inhibitors: Activities and Regulations in Vertebrate Head Development

Frontiers in Cell and Developmental Biology, 2021
Since its first discovery in the late 90s, Wnt canonical signaling has been demonstrated to affect a large variety of neural developmental processes, including, but not limited to, embryonic axis formation, neural proliferation, fate determination, and ...
Johnny Bou-Rouphael, Béatrice C. Durand
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Basal forebrain atrophy in frontotemporal dementia [PDF]

, 2020
Background: The basal forebrain is a subcortical structure that plays an important role in learning, attention, and memory. Despite the known subcortical involvement in frontotemporal dementia (FTD), there is little research into the role of the basal ...
Cardoso, MJ, Ourselin, S, Rohrer, JD, Cash, DM, Bocchetta, M, Neason, MR, Warren, JD, Modat, M, Convery, RS   +8 more
core   +3 more sources

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source