Results 81 to 90 of about 185,793 (320)

Comparative Single‐Cell Transcriptomic Atlas Reveals the Genetic Regulation of Reproductive Traits

Advanced Science, EarlyView.
A cross‐species single‐cell transcriptomic atlas of reproductive and central nervous system tissues from sheep and humans reveals conserved cellular programs and regulatory networks that regulated fertility. Integration with GWAS for sheep lifetime average litter size identifies UNC5–SLIT–BMP signaling as a core pathway coordinating neuroendocrine ...
Bingru Zhao, Hanpeng Luo, Dailu Guan, Xuefeng Fu, Feng Wang, Guoming Zhang, Shanglai Li, Hua Yang, Yanli Zhang   +8 more
wiley   +1 more source

A Novel Acetylcholine Nanosensor for Single Vesicle Storage and Sub‐Quantal Exocytosis in Living Neurons and Organoids

Angewandte Chemie, EarlyView.
Schematic representation of M@E@CF nanosensors for detecting vesicular storage and release in cholinergic neurons and brain organoids. (A) Nano‐tip microelectrodes modification via molds fabricated through 3D printing. (B) the reaction mechanism for acetylcholine detection at the electrode interface.
Wanying Zhu, Yufan Zhang, Hanwen Yu, Da Wang, Xinyue Zhang, Xiaowen Du, Shanshan Wu, Bingzhi Li, Yizhou Zhang, Hongliang Xin, Xing Guo, Yan Liu   +11 more
wiley   +2 more sources

SCALE method for single-cell ATAC-seq analysis via latent feature extraction. [PDF]

, 2019
Single-cell ATAC-seq (scATAC-seq) profiles the chromatin accessibility landscape at single cell level, thus revealing cell-to-cell variability in gene regulation.
Gao, Ge, Jiang, Tao, Shao, Yanqiu, Tang, Lei, Tian, Kang, Xiong, Lei, Xu, Kui, Zhang, Michael, Zhang, Qiangfeng Cliff   +8 more
core  

SAGE: Spatially Aware Gene Selection and Dual‐View Embedding Fusion for Domain Identification in Spatial Transcriptomics

Advanced Science, EarlyView.
SAGE is a unified framework for spatial domain identification in spatial transcriptomics that jointly models tissue architecture and gene programs. Topic‐driven gene selection (NMF plus classifier‐based scoring) highlights spatially informative genes, while dual‐view graph embedding fuses local expression and non‐local functional relations.
Yi He, Yunpei Xu, Liqing Ding, Hong‐Dong Li, Yaohang Li, Shaokai Wang   +5 more
wiley   +1 more source

Visual and Electrosensory Circuits of the Diencephalon in Mormyrids [PDF]

, 1990
Mormyrids are one of two groups of teleost fishes known to have evolved electroreception, and the concomitant neuroanatomical changes have confounded the interpretation of many of their brain areas in a comparative context, e.g., the diencephalon, where ...
Adams, Bell, Bell, Bell, Bell, Bell, Bell, Bergquist, Braford, Bullock, Bullock, Carr, Ebbesson, Ebbesson, Echteler, Echteler, Erdl, Fiebig, Finger, Franz, Franz, Franz, Grover, Hanker, Harder, Haugede-Carre, Haugede-Carre, Holmgren, Hopkins, Hopkins, Ito, Ito, Ito, Ito, Keller, Keller, Lauder, Lazar, Luiten, Maler, Maler, McCormick, Meek, Meek, Meek, Murakami, Murakami, Murakami, Nieuwenhuys, Nieuwenhuys, Nieuwenhuys, Nieuwenhuys, Northcutt, Northcutt, Northcutt, Northcutt, Sas, Sheldon, Stendell, Stendell, Stendell, Striedter, Striedter, Striedter, Suzuki, Szabo, van der Sprenkel, Weston, Wullimann, Wullimann, Wullimann, Wullimann   +71 more
core   +1 more source

Dorsal Raphe VIP Neurons Are Critical for Survival‐Oriented Vigilance

Advanced Science, EarlyView.
DRNVIP neurons in mice and primates are strategically positioned to influence the central extended amygdala via feedback loops. They regulate the excitability of PKC‐δ neurons in the ovBNST and CeA through glutamate release. Their ablation heightens activity in these regions, disrupts active‐phase sleep architecture, enhances risk assessment behaviors ...
Adriane Guillaumin, Emma Perrot, Thibault Dhellemmes, Laura Boi, Daniel De Castro Medeiros, Christelle Glangetas, Sylvie Dumas, Sandra Dovero, Nathalie Biendon, Elodie Ladeveze, Maëlle Hardel, Marc Landry, Erwan Bezard, Jérôme Baufreton, Gilberto Fisone, François Georges   +15 more
wiley   +1 more source

Task-phase-specific dynamics of basal forebrain neuronal ensembles. [PDF]

, 2014
Cortically projecting basal forebrain neurons play a critical role in learning and attention, and their degeneration accompanies age-related impairments in cognition.
Alexander, Andrew S, Chiba, Andrea A, de Sa, Virginia R, Kolbu, Sean, Nitz, Douglas A, Tingley, David   +5 more
core   +2 more sources

Comparative Neuromechanical Wing‐Actuation Architectures of Flapping Flight in Insects, Hummingbirds, and Robots

Advanced Intelligent Systems, EarlyView.
Natural fliers achieve remarkable aerial performance through diverse wing neuromechanical systems integrating actuation, sensing, and control. This study synthesizes neuromechanical architectures in insects and hummingbirds, identifying two key functional types‐Dual Neural‐Mechanical Oscillator and Neurally‐modulated Mechanical Oscillator‐ and ...
Suyash Agrawal, Jean‐Michel Mongeau, Bret W. Tobalske, Christopher Rahn, Bo Cheng   +4 more
wiley   +1 more source

Olig2/Plp-positive progenitor cells give rise to Bergmann glia in the cerebellum. [PDF]

, 2013
NG2 (nerve/glial antigen2)-expressing cells represent the largest population of postnatal progenitors in the central nervous system and have been classified as oligodendroglial progenitor cells, but the fate and function of these cells remain ...
Chung, S-H, Deng, W, Guo, F, Jiang, P, Pleasure, DE   +4 more
core   +2 more sources

Construction of pathogenic Sec16a mutation mouse model using CRISPR/Cas9

Animal Models and Experimental Medicine, EarlyView.
Yaqiang Hu et al. engineered a pathogenic Sec16a mutant mouse model using CRISPR/Cas9 technology. They observed that the Sec16a mutant mice displayed diminished learning and memory capabilities, along with a limb‐clasping phenotype upon tail suspension.
Yaqiang Hu, Zhiyang Zeng, Xinyu Ming, Shuming Yin, Yuting Guan, Liangcai Gao, Dali Li   +6 more
wiley   +1 more source