Epigenomics‐guided precision oncology: Chromatin variants in prostate tumor evolution
International Journal of Cancer, EarlyView.Abstract Prostate cancer is a common malignancy that in 5%–30% leads to treatment‐resistant and highly aggressive disease. Metastasis‐potential and treatment‐resistance is thought to rely on increased plasticity of the cancer cells—a mechanism whereby cancer cells alter their identity to adapt to changing environments or therapeutic pressures to create
Kira Furlano +6 more
wiley +1 more source
Journal of Pharmacological Sciences, 2005 Sir2 (silent information regulator 2) is an NAD-dependent deacetylase that is broadly conserved from bacteria to humans. It catalyzes a unique deacetylation reaction using NAD, and specific inhibitors and activators of its activity have been discovered ...
Shin Hisahara +3 more
doaj
FoxO3 an important player in fibrogenesis and therapeutic target for idiopathic pulmonary fibrosis
EMBO Molecular Medicine, 2017 Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal parenchymal lung disease with limited therapeutic options, with fibroblast‐to‐myofibroblast transdifferentiation and hyperproliferation playing a major role.
Hamza M Al‐Tamari +12 more
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Forkhead/winged-helix transcription factor whn regulates hair keratin gene expression: Molecular analysis of theNude skin phenotype [PDF]
, 2000 Thomas Schlake +4 more
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The role of UPR‐related long noncoding RNAs in development of endocrine resistance in breast cancer
International Journal of Cancer, EarlyView.Abstract Breast cancer patients who express estrogen receptor α (ER) typically receive endocrine therapy as a first‐line treatment. Most ER‐positive breast cancer patients initially respond to endocrine therapy, but up to 40% of patients develop resistance over time, and the main mechanism is aberrant activation of ER signaling pathways.
Wen Liu, Sahil Gupta, Sanjeev Gupta
wiley +1 more source
Chromosomal Duplication Involving the Forkhead Transcription Factor GeneFOXC1Causes Iris Hypoplasia and Glaucoma [PDF]
, 2000 Ordan J. Lehmann +11 more
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iMetaOmics, EarlyView.This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu +8 more
wiley +1 more source
Insulin Inhibits the Activation of Transcription by a C-terminal Fragment of the Forkhead Transcription Factor FKHR [PDF]
, 2000 M. Tomizawa +5 more
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Cloning and expression pattern of a zebrafish homolog of forkhead activin signal transducer (FAST), a transcription factor mediating Nodal-related signals [PDF]
, 2000 Barbara Boggetti +5 more
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Cell Apoptosis and Glucocorticoid‐Induced Osteonecrosis
Med Research, EarlyView.The review identifies glucocorticoid‐induced osteocyte/osteoblast apoptosis as central to femoral head osteonecrosis (GION), mediated through STAT1‐caspase‐3, PI3K/Akt, Wnt/β‐catenin, and oxidative stress pathways. Emerging therapies targeting these pathways (e.g., HIF‐1α stabilization, AMPK activation, and exosome‐mediated miRNA delivery) show ...
Xiumei Tang +7 more
wiley +1 more source