Results 121 to 130 of about 626,933 (316)

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Diabetes and dyslipidemia: characterizing lipoprotein metabolism

Diabetes, Metabolic Syndrome and Obesity, 2017
GH Tomkin,1,2 D Owens1,2 1Diabetes Institute of Ireland, Beacon Hospital, 2Trinity College, University of Dublin, Dublin, Ireland Abstract: Premature atherosclerosis in diabetes accounts for much of the decreased life span.
Tomkin GH, Owens D
doaj  

Monorail/Foxa2 regulates floorplate differentiation and specification of oligodendrocytes, serotonergic raphe neurones and cranial motoneurones [PDF]

, 2005
In this study, we elucidate the roles of the winged-helix transcription factor Foxa2 in ventral CNS development in zebrafish. Through cloning of monorail (mol), which we find encodes the transcription factor Foxa2, and phenotypic analysis of mol ...
Diamond, B, Frohnhoefer, HG, Gardiner, RM, Geisler, R, Heisenberg, CP, Houart, C, Lele, Z, Mangoli, M, Mercurio, S, Neumann, CJ, Norton, WH, Pogoda, HM, Rastegar, S, Rauch, GJ, Rees, M, Russell, C, Schilling, TF, Stickney, HL, Strahle, U, Talbot, WS, Teraoka, H, Wilson, SW   +21 more
core  

The replicative lifespan-extending deletion of SGF73 results in altered ribosomal gene expression in yeast. [PDF]

, 2017
Sgf73, a core component of SAGA, is the yeast orthologue of ataxin-7, which undergoes CAG-polyglutamine repeat expansion leading to the human neurodegenerative disease spinocerebellar ataxia type 7 (SCA7).
Garza, Renee M, Kennedy, Brian K, La Spada, Albert R, Mason, Amanda G, McCormick, Mark A, Patel, Bhumil, Pillus, Lorraine   +6 more
core   +2 more sources

The Roles of FoxO Transcription Factors in Regulation of Bone Cells Function

International Journal of Molecular Sciences, 2020
Forkhead box class O family member proteins (FoxOs) are evolutionarily conserved transcription factors for their highly conserved DNA-binding domain.
Xiaoli Ma, Peihong Su, C. Yin, Xiao Lin, Xue Wang, Yongguang Gao, Suryaji Patil, Abdul Rouf War, Abdul Qadir, Ye Tian, A. Qian   +10 more
semanticscholar   +1 more source

Forkhead Transcription Factor FKHR-L1 Modulates Cytokine-Dependent Transcriptional Regulation of p27^KIP1 [PDF]

Molecular and Cellular Biology, 2000
Interleukin-3 (IL-3), IL-5, and granulocyte-macrophage colony-stimulating factor regulate the survival, proliferation, and differentiation of hematopoietic lineages. Phosphatidylinositol 3-kinase (PI3K) has been implicated in the regulation of these processes.
Dijkers, P F, Medema, R H, Pals, C, Banerji, L, Thomas, N S B, Lam, E W F, Burgering, B M T, Raaijmakers, J A M, Lammers, J W J, Koenderman, L, Coffer, P J   +10 more
openaire   +5 more sources

RORγt‐APCs: The New Masters of Oral Tolerance

Barrier Immunity, EarlyView.
ABSTRACT Oral tolerance is defined by the hypo‐responsiveness of our body to fed antigens, and its failure can lead to immune‐mediated diseases, such as allergy, chronic inflammation and autoimmune diseases. Decades of research have demonstrated that antigen‐presenting cells (APCs) promote oral tolerance by inducing regulatory T cells (Tregs) and/or ...
Thierry Gauthier, WanJun Chen
wiley   +1 more source

New insights into FoxE1 functions: identification of direct FoxE1 targets in thyroid cells [PDF]

, 2015
This is an open-access article distributed under the terms of the Creative Commons Attribution License.[Background]: FoxE1 is a thyroid-specific forkhead transcription factor essential for thyroid gland development, as well as for the maintenance of the ...
Fernández, Lara P., Gómez-López, Gonzalo, López-Márquez, Arístides, Martínez, Ángel M., Santisteban, Pilar   +4 more
core   +2 more sources

Ontogeny of RSPO1, FOXL2, and RUNX1 during ovarian differentiation in the marsupial tammar wallaby

Developmental Dynamics, EarlyView.
Abstract Background RSPO1 and FOXL2 are female sex‐determining genes involved in the differentiation and organization of the ovary in some eutherian mammals. Mutations or loss of function of these genes are associated with partial to full sex reversal in mice, humans, and goats.
Monika R. Paranjpe, Yu Chen, Geoff Shaw, Marilyn B. Renfree   +3 more
wiley   +1 more source

Cell cycle regulated transcription: from yeast to cancer [version 1; referees: 2 approved]

F1000Research, 2016
Recent studies have revealed exciting new functions for forkhead transcription factors in cell proliferation and development. Cell proliferation is a fundamental process controlled by multiple overlapping mechanisms, and the control of gene expression ...
Christopher J. McInerny
doaj   +1 more source