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Forkhead Transcription Factors in Health and Disease.
Trends in Genetics, 2020Forkhead box (FOX) proteins belong to an evolutionarily conserved family of transcription factors that has evolved by gene/genome duplication. FOX family members have undergone sequence and regulatory diversification. However, they have retained some degree of functional redundancy, in addition to playing specific roles, both during development and in ...
Laetitia Herman +2 more
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Regulation of mitochondrial function by forkhead transcription factors
Biochimie, 2022Mitochondria play a central role in several important cellular processes such as energy production, apoptosis, fatty acid catabolism, calcium regulation, and cellular stress response. Multiple nuclear transcription factors have been reported for their role in the regulation of mitochondrial gene expression.
Maria Sona Jerome +3 more
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Forkhead transcription factors in immunology
CMLS Cellular and Molecular Life Sciences, 2005The forkhead (Fox) gene family comprises a diverse group of "winged-helix" transcription factors that play important roles in development, metabolism, cancer and aging. Recently, several forkhead genes have been demonstrated to play critical roles in lymphocyte development and effector function, including Foxp3 in the development of regulatory T cells,
H, Jonsson, S L, Peng
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Ferroptosis, Iron Metabolism, and Forkhead Transcription Factors (FoxOs)
Current Neurovascular Research, 2023openaire +2 more sources
Forkhead transcription factor foxe1 regulates chondrogenesis in zebrafish
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 2009AbstractForkhead transcription factor (Fox) e1 is a causative gene for Bamforth–Lazarus syndrome, which is characterized by hypothyroidism and cleft palate. Applying degenerate polymerase chain reaction using primers specific for the conserved forkhead domain, we identified zebrafish foxe1 (foxe1).
Chisako, Nakada +3 more
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Forkhead family transcription factor FoxO and neural differentiation
neurogenetics, 2012The Forkhead Box subgroup O (FoxO) transcription factor family is one of the most important downstream targets of the phosphatidylinositol 3-kinase/protein kinase B signaling pathway playing an important role in many biological functions including transcriptional regulation of cellular differentiation.
Wen, Qiang +4 more
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Forkhead Transcription Factors Block Cell Cycle
Science's STKE, 2000Forkhead proteins are involved in controlling the life span of nematodes. Their activation through phosphorylation by protein kinase B (PKB) is thought to protect cells from cell death (see news and views article by Pulverer). Medema et al . show that in mammalian cells Forkhead transcription factors regulate the
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Expression of forkhead transcription factors in human granulosa cells
Fertility and Sterility, 2009Members of the forkhead box O1 (FOXO) family of transcription factors are expressed in granulosa cells during various stages of follicle development, and evidence from rodent and other model systems suggests that they may be involved in regulating follicular activation and oocyte maturation.
Margareta D, Pisarska +5 more
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Forkhead transcription factors: key players in health and disease
Trends in Genetics, 2011Forkhead box (FOX) proteins constitute an evolutionarily conserved family of transcription factors with a central role not only during development, but also in the adult organism. Thus, the misregulation and/or mutation of FOX genes often induce human genetic diseases, promote cancer or deregulate ageing.
Benayoun, Bérénice A +2 more
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Forkhead transcription factor Foxo1 is essential for adipocyte differentiation
In Vitro Cellular & Developmental Biology - Animal, 2009We analyzed the physiological role of forkhead box class O 1 (Foxo1) in adipocyte differentiation by suppressing Foxo1 mRNAwith siRNA specific for Foxo1.Mouse 3T3-L1 preadipocytes infected with an adenovirus expressing Foxo1-siRNA showed a marked decrease in lipid droplet formation when induced to differentiate into adipocytes.
Keisuke, Munekata, Kazuichi, Sakamoto
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