Results 91 to 100 of about 340,216 (285)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
The Hamilton formalism with fractional derivatives
Journal of Mathematical Analysis and Applications, 2007 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Rabei, Eqab M. +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Topics in Linguistics, 2018 This paper addresses the classification of morphemes in a generative framework. Referring to existing theoretical models of generative morphosyntax (e.g.
Veselovská Ludmila
doaj +1 more source
Formal Integration of Derived Foliations
Frobenius' theorem in differential geometry asserts that every involutive subbundle of the tangent bundle of a manifold $M$ integrates to a decomposition of $M$ into smooth leaves. We prove an infinitesimal analogue of this result for locally coherent qcqs schemes $X$ over coherent rings.
Brantner, Lukas +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
The Etymology of the Proto-Slavic *jarьmъ, *jarьmo ‘yoke’
Rasprave Instituta za Hrvatski Jezik i Jezikoslovlje, 2010 The article discusses the etymology of the Proto-Slavic word *jarьmъ, *jarьmo, which denotes a yoke that yokes two oxen. It is argued that this word reflects the original plural to the word for ‘arm, shoulder’ in Balto-Slavic.
Tijmen Pronk
doaj
Multifractal formalism derived from thermodynamics
, 2010 We show that under quite general conditions, various multifractal spectra may be obtained as Legendre transforms of functions $T\colon \RR\to \RR$ arising in the thermodynamic formalism. We impose minimal requirements on the maps we consider, and obtain partial results for any continuous map $f$ on a compact metric space.
openaire +2 more sources
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source